Movement‐related cortical potentials preceding repetitive and random‐choice hand movements in parkinson's disease

Touge, Tetsuo; Werhahn, Konrad J.; Rothwell, John C.; Marsden, C. D.

doi:10.1002/ana.410370613

Cited by 52 publications

(40 citation statements)

References 13 publications

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“…29,31,32 These findings and the rTMS results reported here do not necessarily conflict. The reduced facilitation from the nonprimary cortical motor areas could readily explain why rTMS fails to increase the size of the MEPs in PD.…”

Section: Discussionsupporting

confidence: 56%

“…Reduced cortical activity agrees with abnormal electroencephalographic (EEG) data observed in PD patients, and abnormal recordings of brain activity preceding voluntary movements. [25][26][27][28][29] In an earlier study testing the excitability of cortical motor areas with paired shocks delivered at long interstimulus intervals (100-200 msec), we found a more inhibited test response in patients with PD. 19 Because spinal mechanisms are unlikely to act at intervals greater than 100 msec, in normal subjects the inhibition observed at long interstimulus intervals probably arises from increased intracortical inhibition.…”

Section: Discussionmentioning

confidence: 99%

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Repetitive magnetic stimulation of cortical motor areas in Parkinson's disease: Implications for the pathophysiology of cortical function

et al. 2001

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We investigated the neurophysiological and clinical effects of repetitive magnetic stimulation (rTMS) delivered to the cortical motor areas in healthy subjects and patients with Parkinson's disease. rTMS was delivered with a high speed magnetic stimulator (Cadwell, Kennewick, WA) through a figure-eight coil centred on the primary motor area at a stimulus intensity of 120% motor threshold. Trains of 10 stimuli were delivered at frequencies of 5 Hz while subjects were at rest and during a voluntary contraction of the contralateral first dorsal interosseous muscle. In normal subjects at rest, the muscle evoked responses (MEPs) to each stimulus in a train of magnetic stimuli progressively increased in size during the train. rTMS left the MEPs unchanged in patients off therapy and had a small facilitatory effect in those on therapy. In normal subjects and patients, 5-Hz rTMS trains delivered during a voluntary contraction of the target muscle left the MEP unchanged in size. MEPs were followed by a silent period that increased in duration during the course of the train. The silent period duration increased to a similar extent in patients and controls. The reduced rTMS-induced facilitation of MEPs in patients with Parkinson's disease reflects a decreased facilitation of the excitatory cells in the cortical motor areas.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Repetitive magnetic stimulation of cortical motor areas in Parkinson's disease: Implications for the pathophysiology of cortical function

et al. 2001

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“…This suggests a significant dysfunction of the motor neural networks, even in patients with few symptoms. This finding is consistent with previous descriptions of reduced amplitude of BP preceding other movements in PD patients, even in the early stages 12,22,23,24,25,26 . It is also in accordance with the early clinical finding of paucity of facial expression and reduced blink rate in PD patients, suggesting that neural systems related to motor planning, especially those related to facial expression and blinks, are affected early in PD…”

Section: Discussionsupporting

confidence: 93%

“…Although most studies have reported smaller BP amplitudes in PD patients compared to normal controls, some studies have reported no differences 21,24,26 or even larger amplitudes 27,28 . The reasons for these discrepancies are not clear.…”

mentioning

confidence: 96%

Bereitschaftspotential preceding eyelid blinks in Parkinson’s disease

Mota

Coriolano

Lins

2017

Arq. Neuro-Psiquiatr.

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The Bereitschaftspotential (BP) is a negative wave observed in EEG retrograde averaging, preceding a motor act. The objective was to study the BP preceding voluntary eyelid blinks in Parkinson’s disease (PD) patients during off and on phases of levodopa. Methods Ten PD patients in stages 1 and 2 of the Hoehn & Yahr classification were compared to 18 healthy controls. Artifact-free EEG segments of two seconds preceding the onset of the blink potential were averaged and analyzed, and the statistical significance of the measured amplitudes were evaluated by analysis of variance models. Results The presence of a BP in the PD patients was demonstrated. The mean amplitudes at 0 ms were respectively 0.6 µV and 3.3 µV for the BP patients and the normal controls, respectively. Conclusions The BP amplitudes were significantly smaller in PD patients than normal participants. The amplitudes of the BP were not modified by levodopa.

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“…Nevertheless, very likely this work will improve our understanding of preparatory volitional motor activity in motor cortico-cortical networks and its modification by brain stimulation. This knowledge will pertain to clinical applications for treatment of patients in whom this activity is disordered, such as in dystonia [Deuschl et al, 1995], Parkinson's disease [Touge et al, 1995], spino-cerebellar ataxia [Lu et al, 2008], traumatic brain injury [Wiese et al, 2004], or cerebral stroke [Green et al, 1999].…”

Section: Introductionmentioning

confidence: 99%

Modulation of preparatory volitional motor cortical activity by paired associative transcranial magnetic stimulation

Lu¹,

Bliem²,

Jung³

et al. 2009

Human Brain Mapping

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Paired associative transcranial magnetic stimulation (PAS) has been shown to induce long-term potentiation (LTP)-like or long-term depression (LTD)-like change in excitability of human primary motor cortex (M1), as probed by motor evoked potential (MEP) amplitude. In contrast, little is known about PAS effects on volitional motor cortical activity. In 10 healthy subjects, movement related cortical potentials (MRCP) were recorded to index volitional motor cortical activity during preparation of simple thumb abduction (prime mover: abductor pollicis brevis, APB) or wrist extension movements (prime mover: extensor carpi radialis, ECR). PAS(LTP) increased, PAS(LTD) decreased, and PAS(control) did not change MEP(APB), while MEP(ECR), not targeted by PAS, remained unchanged in all PAS conditions. PAS(LTP) decreased MRCP negativity during the late Bereitschaftspotential (-500 to 0 ms before movement onset), only in the APB task, and predominantly over central scalp electrodes contralateral to the thumb movements. This effect correlated negatively with the PAS(LTP) induced increase in MEP(APB). PAS(LTD) and PAS(control) did not affect MRCP amplitude. Findings indicate a specific interference of PAS with preparatory volitional motor cortical activity, suggestive of a net result caused by increased M1 excitability and disrupted effective connectivity between premotor areas and M1.

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Movement‐related cortical potentials preceding repetitive and random‐choice hand movements in parkinson's disease

Cited by 52 publications

References 13 publications

Repetitive magnetic stimulation of cortical motor areas in Parkinson's disease: Implications for the pathophysiology of cortical function

Repetitive magnetic stimulation of cortical motor areas in Parkinson's disease: Implications for the pathophysiology of cortical function

Bereitschaftspotential preceding eyelid blinks in Parkinson’s disease

Modulation of preparatory volitional motor cortical activity by paired associative transcranial magnetic stimulation

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