Movement-related change of electrocorticographic activity in human supplementary motor area proper

Ohara, Shuichi; Ikeda, Akio; Kunieda, Takeharu; Yazawa, Shogo; Baba, Koichi; Nakagawa, Takashi; Taki, Waro; Hashimoto, Nobuo; Mihara, Tadahiro; Shibasaki, Hiroshi

doi:10.1093/brain/123.6.1203

Cited by 193 publications

(133 citation statements)

References 68 publications

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“…The behavior of the present LFPOs shows similarities with cerebral "resting" rhythmic activities of wakefulness arresting to sensory or motor information, such as ␣ and rhythms. Oscillations most often occur during a premovement period and cease around movement onset (Donoghue et al, 1998;Ohara et al, 2000;Pfurtscheller et al, 2003). The decrease in -oscillation approximately coincides with the increase in ␥ oscillation above 30 Hz (Pfurtscheller et al, 2003) and with the appearance of firing rate modulation coupled with the motor action (Donoghue et al, 1998).…”

Section: Physiological Role Of 160 Hz Oscillationsmentioning

confidence: 89%

Inactivation of Calcium-Binding Protein Genes Induces 160 Hz Oscillations in the Cerebellar Cortex of Alert Mice

Chéron¹,

Gall²,

Servais³

et al. 2004

J. Neurosci.

107

102

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Oscillations in neuronal populations may either be imposed by intrinsically oscillating pacemakers neurons or emerge from specific attributes of a distributed network of connected neurons. Calretinin and calbindin are two calcium-binding proteins involved in the shaping of intraneuronal Ca 2ϩ fluxes. However, although their physiological function has been studied extensively at the level of a single neuron, little is known about their role at the network level. Here we found that null mutations of genes encoding calretinin or calbindin induce 160 Hz local field potential oscillations in the cerebellar cortex of alert mice. These oscillations reached maximum amplitude just beneath the Purkinje cell bodies and are reinforced in the cerebellum of mice deficient in both calretinin and calbindin. Purkinje cells fired simple spikes phase locked to the oscillations and synchronized along the parallel fiber axis. The oscillations reversibly disappeared when gap junctions or either GABA A or NMDA receptors were blocked. Cutaneous stimulation of the whisker region transiently suppressed the oscillations. However, the intrinsic somatic excitability of Purkinje cells recorded in slice preparation was not significantly altered in mutant mice. Functionally, these results suggest that 160 Hz oscillation emerges from a network mechanism combining synchronization of Purkinje cell assemblies through parallel fiber excitation and the network of coupled interneurons of the molecular layer. These findings demonstrate that subtle genetically induced modifications of Ca 2ϩ homeostasis in specific neuron types can alter the observed dynamics of the global network.

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Section: Physiological Role Of 160 Hz Oscillationsmentioning

confidence: 89%

Inactivation of Calcium-Binding Protein Genes Induces 160 Hz Oscillations in the Cerebellar Cortex of Alert Mice

Chéron¹,

Gall²,

Servais³

et al. 2004

J. Neurosci.

107

102

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“…Mu power is reduced during both action observation and execution. Mu is most powerful in the primary somatosensory cortex (SI) (Salmelin et al, 1995;Ohara et al, 2000;Caetano et al, 2007); however, we lack evidence for the assumption that regions of the MNS, the ventral premotor cortex in particular (Pineda, 2005), are responsible for -modulation and that fMRI and -suppression experiments measure the functioning of the same MNS. Elegant MEG experiments also investigated an ϳ20 Hz -component which rebounds after action observation and execution (Hari et al, 1998), but because optimal designs to study 10 Hz and 20 Hz components differ, we focus here on the most studied, 10 Hz component, and will use as shorthand for that component alone.…”

Section: Introductionmentioning

confidence: 95%

μ-Suppression during Action Observation and Execution Correlates with BOLD in Dorsal Premotor, Inferior Parietal, and SI Cortices

Arnstein¹,

Cui²,

Keysers³

et al. 2011

J. Neurosci.

222

182

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The discovery of mirror neurons in the monkey, that fire during both the execution and the observation of the same action, sparked great interest in studying the human equivalent. For over a decade, both functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) have been used to quantify activity in the human mirror neuron system (MNS)-yet, little is still known about how fMRI and EEG measures of the MNS relate to each other. To test the frequent assumption that regions of the MNS as evidenced by fMRI are the origin of the suppression of the EEG -rhythm during both action execution and observation, we recorded EEG and BOLD-fMRI signals simultaneously while participants observed and executed actions. We found that the suppression of the -rhythm in EEG covaried with BOLD activity in typical MNS regions, inferior parietal lobe (IPL), dorsal premotor (dPM) and primary somatosensory cortex (BA2), during both action observation and execution. In contrast, in BA44, only nonoverlapping voxels correlated with -suppression during observation and execution. These findings provide direct support for the notion that -suppression is a valid indicator of MNS activity in BA2, IPL, and dPM, but argues against the idea that mirror neurons in BA44 are the prime source of -suppression. These results shed light on the neural basis of -suppression and provide a basis for integrating more closely the flourishing but often separate literatures on the MNS using fMRI and EEG.

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“…Indeed, the extended frequency response of invasive EEG recordings has shown that during functional activation of cerebral cortex, gamma activity occurs over a much broader range of frequencies that extend far beyond the traditional 40-Hz gamma band typically observed in scalp EEG (Crone et al, 1998a;Crone et al, 2006). These non-phase-locked responses in "high-gamma" frequencies, typically greater than 60 Hz and extending as high as 200 Hz, have been observed during functional activation in a variety of cortical domains, including sensorimotor (Crone et al, 1998a;Ohara et al, 2000;Pfurtscheller et al, 2003;Leuthardt et al, 2004), oculomotor (Lachaux et. al., 2006), auditory (Crone et al, 2001a;Ray et al, 2003;Edwards et al, 2005), visual (Crone et al, 2001b;Lachaux et al, 2005;Tanji et al, 2005), and language (Crone et al, 2001b;Sinai et al, 2005) cortices.…”

Section: Introductionmentioning

confidence: 99%

High-frequency gamma activity (80–150Hz) is increased in human cortex during selective attention

Ray

Niebur

Hsiao

et al. 2008

Clinical Neurophysiology

212

163

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Objective: To study the role of gamma oscillations (>30 Hz) in selective attention using subdural electrocorticography (ECoG) in humans. Methods:We recorded ECoG in human subjects implanted with subdural electrodes for epilepsy surgery. Sequences of auditory tones and tactile vibrations of 800 ms duration were presented asynchronously, and subjects were asked to selectively attend to one of the two stimulus modalities in order to detect an amplitude increase at 400 ms in some of the stimuli.Results: Event-related ECoG gamma activity was greater over auditory cortex when subjects attended auditory stimuli and was greater over somatosensory cortex when subjects attended vibrotactile stimuli. Furthermore, gamma activity was also observed over prefrontal cortex when stimuli appeared in either modality, but only when they were attended. Attentional modulation of gamma power began ∼400 ms after stimulus onset, consistent with the temporal demands on attention. The increase in gamma activity was greatest at frequencies between 80 and 150 Hz, in the so-called high gamma frequency range.Conclusions: There appears to be a strong link between activity in the high-gamma range (80-150 Hz) and selective attention.Significance: Selective attention is correlated with increased activity in a frequency range that is significantly higher than what has been reported previously using EEG recordings.

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Movement-related change of electrocorticographic activity in human supplementary motor area proper

Cited by 193 publications

References 68 publications

Inactivation of Calcium-Binding Protein Genes Induces 160 Hz Oscillations in the Cerebellar Cortex of Alert Mice

Inactivation of Calcium-Binding Protein Genes Induces 160 Hz Oscillations in the Cerebellar Cortex of Alert Mice

μ-Suppression during Action Observation and Execution Correlates with BOLD in Dorsal Premotor, Inferior Parietal, and SI Cortices

High-frequency gamma activity (80–150Hz) is increased in human cortex during selective attention

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