Movement disorders in systemic lupus erythematosus and the antiphospholipid syndrome

Baizabal‐Carvallo, José Fidel; Bonnet, Cécilia; Jankovic, Joseph

doi:10.1007/s00702-013-1023-z

Cited by 89 publications

(66 citation statements)

References 117 publications

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“…In a series of 41 patients with SLE, the authors identified 4 patients with movement disorders (2 with parkinsonism and 1 each with myoclonus and chorea) 45. Of clinical relevance is the finding that chorea may precede the onset of other findings of SLE in up to 22% of patients 46. In our own centre a systematic and careful evaluation of 54 consecutive patients with SLE we found that movement disorders were rare, 1 patient had chorea and the other one, parkinsonism.…”

Section: Sle and Related Conditionsmentioning

confidence: 99%

Autoimmune choreas

Cardoso

2016

J Neurol Neurosurg Psychiatry

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Chorea, a movement disorder characterised by a continuous flow of unpredictable muscle contractions, has a myriad of genetic and non-genetic causes. Although autoimmune processes are rare aetiology of chorea, they are relevant both for researchers and clinicians. The aim of this article is to provide a review of the epidemiology, clinical and laboratory features, pathogenesis and management of the most common autoimmune causes of chorea. Emphasis is given particularly to Sydenham's chorea, systemic lupus erythematosus, primary antiphospolipid antibody syndrome, paraneoplastic chorea and anti--methyl-d-aspartate receptor encephalitis.

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Section: Sle and Related Conditionsmentioning

confidence: 99%

Autoimmune choreas

Cardoso

2016

J Neurol Neurosurg Psychiatry

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“…Nonetheless, parkinsonism, myoclonus and dystonia were described and an autoimmune or thromboembolic disease mechanism has been proposed for their occurrence 39 . Chorea is the most described manifestation and may be the first manifestation in SLE occurring in 2% of adult patients, predominantly in women.…”

Section: Movement Disordersmentioning

confidence: 99%

“…It can be unilateral or bilateral and remit spontaneously. Current evidence suggests an autoimmune mechanism related to aPL antibodies, but focal cerebral ischemia is rarely evidenced 39 . Sydenham chorea is the most common cause of acute chorea in children and it is one important differential diagnosis in chorea associated with lupus, especially in pediatric patients.…”

Section: Movement Disordersmentioning

confidence: 99%

Neuropsychiatric Lupus in clinical practice

Alessi

Dutra

Neto

et al. 2016

Arq. Neuro-Psiquiatr.

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs, characterized by the production of autoantibodies and the development of tissue injury. The etiology of SLE is partially known, involving multiple genetic and environmental factors. As many as 50% of patients with SLE have neurological involvement during the course of their disease. Neurological manifestations are associated with impaired quality of life, and high morbidity and mortality rates. Nineteen neuropsychiatric syndromes have been identified associated with SLE, and can be divided into central and peripheral manifestations. This article reviews major neuropsychiatric manifestations in patients with SLE and discusses their clinical features, radiological findings and treatment options.

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“…Symptoms may improve during sleep or in a supine position. Huntington's disease, Wilson's disease, prion diseases, Sydenham chorea, systemic lupus erythematosus, antiphospholipid antibody syndrome, anti-N-methyl-D-aspartate receptor encephalitis and other autoimmune diseases as illustrated [31][32][33][34][35] in Table 6. The workup may include selected laboratory studies, as well as imaging modalities such as CT, MRI or positron emission tomography (PET).…”

Section: Akathisiamentioning

confidence: 99%

Identification and management of tardive dyskinesia: A case series and literature review

Khouzam

2015

Postgraduate Medicine

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Tardive dyskinesia (TD) is a serious, disabling and potentially permanent, neurological hyperkinetic movement disorder that occurs after months or years of taking dopamine receptor-blocking agents. The pathophysiology of TD is complex, multifactorial and still not fully understood. Although there is no identified effective and standard treatment for TD, several agents have been tried for the management of this motor disturbance. The aim of this case series is to review the literature in regard to the identification, diagnosis and the treatment of TD with anticholinergics, anticholinergic medication withdrawal, cholinergic agents, botulinum toxin intramuscular injections, tetrabenazine, levetiracetam, propranolol and zolpidem, and to describe one case of TD that responded favorably to clonazepam and two cases of TD that responded favorably to Ginkgo biloba.

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Movement disorders in systemic lupus erythematosus and the antiphospholipid syndrome

Cited by 89 publications

References 117 publications

Autoimmune choreas

Autoimmune choreas

Neuropsychiatric Lupus in clinical practice

Identification and management of tardive dyskinesia: A case series and literature review

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