“…In a case-crossover design, the rate of outcome occurrence is assumed to remain unchanged across the hazard and reference periods, while the risk of parkinsonism and related movement disorders may be subject to age and neuropathy. 13,43 However, the short observation period in our study (390-, 270-, or 210-day) can be considered to mitigate their impact, as in other case-crossover studies. 30,31 Third, as in previous studies, 24,25 this study could not distinguish between patients with drugrelated parkinsonism and those with PD.…”
Section: Discussionmentioning
confidence: 98%
“…Second, estimates may be confounded by aging and exacerbation of comorbidities. In a case‐crossover design, the rate of outcome occurrence is assumed to remain unchanged across the hazard and reference periods, while the risk of parkinsonism and related movement disorders may be subject to age and neuropathy 13,43 . However, the short observation period in our study (390‐, 270‐, or 210‐day) can be considered to mitigate their impact, as in other case‐crossover studies 30,31 .…”
Introduction
A safety signal concerning parkinsonism and related movement disorders with gabapentinoids (gabapentin and pregabalin) or tramadol was detected by reviewing individual case reports and data mining in spontaneous report databases. Well‐designed pharmacoepidemiological studies are needed to assess the signal.
Objective
This study aimed to investigate the association of exposure to gabapentinoids or tramadol with the risk of parkinsonism and related movement disorders.
Methods
We conducted a case‐crossover study using a Japanese electronic medical records database. Patients with newly diagnosed parkinsonism or related movement disorders between January 1, 2007, and April 14, 2019, were identified. The diagnosis date of outcomes was defined as the index date. We assessed the exposure of each patient to gabapentinoids or tramadol during a 90‐day hazard period ending 1 day before the index date and in three 90‐day reference periods. Multivariable conditional logistic regression models were employed to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs). To confirm the robustness of the primary findings, we also performed sensitivity analyses using a case–case‐time‐control design, a different time window for hazard and reference periods, a different definition of outcome, and different number of reference periods.
Results
A total of 28,972 eligible cases were included in the primary analysis. Exposure to gabapentinoids (aOR, 2.12; 95% CI, 1.73–2.61) and tramadol (aOR, 2.04; 95% CI, 1.57–2.64) was associated with increased risk. Results were consistent across sensitivity analyses.
Conclusion
Our findings serve as a caution to physicians who prescribe gabapentinoids or tramadol in routine clinical practice.
“…In a case-crossover design, the rate of outcome occurrence is assumed to remain unchanged across the hazard and reference periods, while the risk of parkinsonism and related movement disorders may be subject to age and neuropathy. 13,43 However, the short observation period in our study (390-, 270-, or 210-day) can be considered to mitigate their impact, as in other case-crossover studies. 30,31 Third, as in previous studies, 24,25 this study could not distinguish between patients with drugrelated parkinsonism and those with PD.…”
Section: Discussionmentioning
confidence: 98%
“…Second, estimates may be confounded by aging and exacerbation of comorbidities. In a case‐crossover design, the rate of outcome occurrence is assumed to remain unchanged across the hazard and reference periods, while the risk of parkinsonism and related movement disorders may be subject to age and neuropathy 13,43 . However, the short observation period in our study (390‐, 270‐, or 210‐day) can be considered to mitigate their impact, as in other case‐crossover studies 30,31 .…”
Introduction
A safety signal concerning parkinsonism and related movement disorders with gabapentinoids (gabapentin and pregabalin) or tramadol was detected by reviewing individual case reports and data mining in spontaneous report databases. Well‐designed pharmacoepidemiological studies are needed to assess the signal.
Objective
This study aimed to investigate the association of exposure to gabapentinoids or tramadol with the risk of parkinsonism and related movement disorders.
Methods
We conducted a case‐crossover study using a Japanese electronic medical records database. Patients with newly diagnosed parkinsonism or related movement disorders between January 1, 2007, and April 14, 2019, were identified. The diagnosis date of outcomes was defined as the index date. We assessed the exposure of each patient to gabapentinoids or tramadol during a 90‐day hazard period ending 1 day before the index date and in three 90‐day reference periods. Multivariable conditional logistic regression models were employed to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs). To confirm the robustness of the primary findings, we also performed sensitivity analyses using a case–case‐time‐control design, a different time window for hazard and reference periods, a different definition of outcome, and different number of reference periods.
Results
A total of 28,972 eligible cases were included in the primary analysis. Exposure to gabapentinoids (aOR, 2.12; 95% CI, 1.73–2.61) and tramadol (aOR, 2.04; 95% CI, 1.57–2.64) was associated with increased risk. Results were consistent across sensitivity analyses.
Conclusion
Our findings serve as a caution to physicians who prescribe gabapentinoids or tramadol in routine clinical practice.
“…However, in a survey, 38% of CMT1A patients reported postural tremors in hands. 34,35 Combining the high level of both serum and CSF S100 protein and normal MRI, we proposed that the proprioceptive impairment might be the cause of the tremors. 34 Sensory ataxia was a cardinal feature in the present patient characterized by loss of position sensation, apallesthesia, and a lack of cerebellar signs, which is described frequently in FLVCR1 gene-related diseases.…”
The mutations of the feline leukemia virus subgroup C receptor‐related protein 1 (FLVCR1) cause ataxia with retinitis pigmentosa. Recent studies indicated a large variation in the phenotype of FLVCR1‐associated diseases. In this report, we describe an adult male who manifested first with tremors in his third decade, followed by retinitis pigmentosa, sensory ataxia, and sensory neuropathy in his fourth decade. While retinitis pigmentosa and sensory ataxia are well‐recognized features of FLVCR1‐associated disease, tremor is rarely described. Whole‐exome sequencing revealed novel compound heterozygous pathogenic FLVCR1 variants: c.498 G > A; p.(Trp166*) and c.369 T > G; p.(Phe123Leu). In addition, we have highlighted the ultrastructural abnormalities of the sural biopsy in this patient.
“…While it has rarely been reported in the context of GBS, tremor is known to be a manifestation of chronic inflammatory demyelinating neuropathy (CIDP) or paraproteinemic neuropathies 3,4 . Neuropathic tremor (NT) is a movement disorder consisting of postural and/or kinetic tremor affecting the distal upper extremities that occurs in the context of a peripheral neuropathy 5 . NT is more common in demyelinating neuropathies, compared to axonal neuropathies; it usually occurs late in the course of an inflammatory or hereditary demyelinating polyneuropathy.…”
mentioning
confidence: 99%
“…3,4 Neuropathic tremor (NT) is a movement disorder consisting of postural and/or kinetic tremor affecting the distal upper extremities that occurs in the context of a peripheral neuropathy. 5 NT is more common in demyelinating neuropathies, compared to axonal neuropathies; it usually occurs late in the course of an inflammatory or hereditary demyelinating polyneuropathy. Presence of tremor has no known correlation with the severity of neuropathy.…”
BackgroundNeuropathic Tremor (NT) is a postural/kinetic tremor of the upper extremity, often encountered in patients with chronic neuropathies such as paraprotein‐associated and hereditary neuropathies.ObjectivesTo describe the clinical and electrophysiological features of NT in a previously underrecognized setting‐ during recovery from Guillain‐Barré Syndrome (GBS).MethodsPatients with a documented diagnosis of GBS in the past, presenting with tremor were identified from review of clinical records. Participants underwent structured, videotaped neurological examination, and electrophysiological analysis using tri‐axial accelerometry‐surface electromyography. Tremor severity was assessed using the Fahn‐Tolosa‐Marin Tremor Rating Scale.ResultsWe describe the clinical and electrophysiological features of 5 patients with GBS associated NT. Our cohort had a fine, fast, and slightly jerky postural tremor of frequency ranging from 8 to 10 Hz. Dystonic posturing and overflow movements were noted in 4/5 patients. Tremor appeared 3 months–5 years after the onset of GBS, when patients had regained near normal muscle strength and deep tendon jerks were well elicitable. Electrophysiological analysis of tremor strongly suggested the presence of a central oscillator in all patients.ConclusionNT is not limited to chronic inflammatory or hereditary neuropathies and may occur in the recovery phase of GBS. The tremor is characterized by a high frequency, jerky postural tremor with dystonic posturing. Electrophysiological evaluation suggests the presence of a central oscillator, hypothetically the cerebellum driven by impaired sensorimotor feedback.
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