Movement disorders and neurochemical changes in zebrafish larvae after bath exposure to fluoxetine (PROZAC)

Airhart, Mark J.; Lee, Deborah H.; Wilson, Tracy D.; Miller, Barney E.; Miller, Merry N.; Skalko, Richard G.

doi:10.1016/j.ntt.2007.07.005

Cited by 150 publications

(105 citation statements)

References 60 publications

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“…Arrows in c indicate individual Purkinje cell bodies Brain Struct Funct (2010) 214:285-302 287 et al 2009b. This is compatible with earlier studies showing that serotonin-specific reuptake inhibitors impair locomotor activity in zebrafish (Airhart et al 2007) and that serotonin stimulates swimming behavior in larval zebrafish (Brustein et al 2003).…”

Section: Structure and Function Of Zebrafish Cns Regions Of Relevancesupporting

confidence: 93%

Transgenic zebrafish models of neurodegenerative diseases

2010

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Since the introduction of the zebrafish as a model for the study of vertebrate developmental biology, an extensive array of techniques for its experimental manipulation and analysis has been developed. Recently it has become apparent that these powerful methodologies might be deployed in order to elucidate the pathogenesis of human neurodegenerative diseases and to identify candidate therapeutic approaches. In this article, we consider evidence that the zebrafish central nervous system provides an appropriate setting in which to model human neurological disease and we review techniques and resources available for generating transgenic models. We then examine recent publications showing that appropriate phenotypes can be provoked in the zebrafish through transgenic manipulations analogous to genetic abnormalities known to cause human tauopathies, polyglutamine diseases or motor neuron degenerations. These studies show proof of concept that findings in zebrafish models can be applicable to the pathogenic mechanisms underlying human diseases. Consequently, the prospects for providing novel insights into neurodegenerative diseases by exploiting transgenic zebrafish models and discovery-driven approaches seem favorable.

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Section: Structure and Function Of Zebrafish Cns Regions Of Relevancesupporting

confidence: 93%

Transgenic zebrafish models of neurodegenerative diseases

2010

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“…Such innervation has not been described in any other species, including Xenopus. Serotonin recently has been identified as a key neurotransmitter that controls swimming behavior in zebrafish (21,22)-but zebrafish larvae do not possess a CG. Our finding therefore leads to many interesting questions about the conservation and the function of this CG/5-HT connectivity in various species.…”

Section: Discussionmentioning

confidence: 99%

“…In zebrafish, the serotonergic (5-HT) neurotransmitter system regulates the establishment of locomotor behavior (21,22). As a first insight into this issue, we explored the possibility of an anatomical relationship between the "cas system" and the "5-HT system" in Astyanax.…”

Section: The Casquette Is Innervated By Fibers Originating From the Tmentioning

confidence: 99%

Conservation, development, and function of a cement gland-like structure in the fish Astyanax mexicanus

Pottin

Hyacinthe

Rétaux

2010

Proc. Natl. Acad. Sci. U.S.A.

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The larvae of the fish Astyanax mexicanus transiently develop a flat and adhesive structure on the top of their heads that we have called "the casquette" (cas, meaning "hat"). We hypothesized that the cas may be a teleostean homolog of the well-studied Xenopus cement gland, despite their different positions and structures. Here we show that the cas has an ectodermal origin, secretes mucus, expresses bone morphogenic protein 4 (Bmp4) and pituitary homeobox 1/2 (Pitx1/2), is innervated by the trigeminal ganglion and serotonergic raphe neurons, and has a role in the control and the development of the larval swimming behavior. These developmental, connectivity, and behavioral functional data support a level of deep homology between the frog cement gland and the Astyanax cas and suggest that attachment organs can develop in varied positions on the head ectoderm by recruitment of a Bmp4-dependent developmental module. We also show that the attachment organs of the cichlid Tilapia mariae larvae display some of these features. We discuss the possibility that these highly diversified attachment glands may be ancestral to chordates and have been lost repetitively in many vertebrate classes.bone morphogenic protein 4 | pituitary homeobox 1/2 | trigeminal | fish behavior | homology

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“…Ряд авторов [32][33][34][35] исследовали эффект седативных соединений на двигательную активность зебрафиш. Эти данные, суммированные в обзоре Barros и соавторов [36], свидетельствуют о применимости данной модели для тестирования действия лекарств на локомоторную активность (см.…”

Section: рисунокunclassified

Zebrafish as a model system for biomedical studies

et al. 2010

BIOMED KHIM

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Ключевые слова: зебрафиш (Danio rerio), разработка лекарств, острая токсичность, тератогенность, апоптоз, рак.ВВЕДЕНИЕ. Биомедицинские исследования, направленные на понимание патогенеза заболеваний человека на клеточном и молекулярном уровне и создание новых терапевтических средств, основаны на использование различных моделей животных. Зебрафиш (Danio rerio) -маленькая (размером до 4,5 см) пресноводная тропическая рыбка, обитающая в Индии и Южной Азии и хорошо известная любителям аквариумных рыб. Традиционно эту рыбку использовали в исследованиях в области молекулярной генетики и биологии развития, однако в последнее время она становится привлекательной в работах по созданию новых лекарственных препаратов и моделировании различных физиологических и патологических процессов [1][2][3][4][5][6].Эмбрион зебрафиш развивается быстро. Уже через три дня после оплодотворения у него функционирует сердце, кровеносная и нервная системы. Через четыре дня появляются личинки (мальки), способные есть и плавать. Эпителиальные клетки кишечника выделяют пищеварительные ферменты, гепатоциты секретируют желчь, панкреатические клетки продуцируют инсулин и карбоксипептидазы. Так как эмбрионы прозрачны, за их развитием можно наблюдать визуально с помощью микроскопа. Эмбрионы зебрафиш легко поглощают низкомолекулярные соединения из воды через кожу и жабры, а после 7 суток развития поглощение происходит через рот (а не через кожу) [7].Срок жизни полосатого Danio 3-5 лет. 120 * -адресат для переписки

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Movement disorders and neurochemical changes in zebrafish larvae after bath exposure to fluoxetine (PROZAC)

Cited by 150 publications

References 60 publications

Transgenic zebrafish models of neurodegenerative diseases

Transgenic zebrafish models of neurodegenerative diseases

Conservation, development, and function of a cement gland-like structure in the fish Astyanax mexicanus

Zebrafish as a model system for biomedical studies

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