Movement Disorders and Hematologic Diseases

Patel, Roshni; Hall, Deborah A.; Eichenseer, Sheila R.; Bailey, Meagan

doi:10.1002/mdc3.13129

Cited by 5 publications

(10 citation statements)

References 140 publications

(175 reference statements)

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“…Firstly, increased blood viscosity may play a role, leading to reduced cerebral blood flow. This happens in hemolytic‐uremic syndrome, which has been described in association with dystonia 10 . Another mechanism may be related to basal ganglia impairment, caused by high bilirubin levels.…”

Section: Discussionmentioning

confidence: 99%

“…This happens in hemolytic-uremic syndrome, which has been described in association with dystonia. 10 Another mechanism may be related to basal ganglia impairment, caused by high bilirubin levels. Bilirubin toxicity on basal ganglia is, in fact, well known.…”

Section: Discussionmentioning

confidence: 99%

“…Bilirubin toxicity on basal ganglia is, in fact, well known. 4,10 Tremor is a feature of Wilson's Disease (WD), 7 which is characterized by liver dysfunction and hemolytic anemia 7 and can be associated with thrombocytopenia, 8 caused by the accumulation of copper. In addition, Bilirubin levels are increased in PD patients, 6 especially…”

Section: Discussionmentioning

confidence: 99%

“…There are few published cases of movement disorders related to hematologic diseases, 10 therefore it is difficult to hypothesize the underlying mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…

Neurological involvement in hematologic diseases is well known, 1,2,10 although movement disorders have rarely been reported. 10 Hereby, we describe a case of tremor/myoclonus syndrome associated to Thrombocytopenic Thrombotic Purpura.

…”

mentioning

confidence: 93%

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Tremor/Myoclonus Syndrome Associated with Thrombotic Thrombocytopenic Purpura: Case Report and Review of Literature

Cartella

Terranova

Zaccone

et al. 2022

Movement Disord Clin Pract

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…There are few published cases of movement disorders related to hematologic diseases, 10 therefore it is difficult to hypothesize the underlying mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…

…”

mentioning

confidence: 93%

See 3 more Smart Citations

Tremor/Myoclonus Syndrome Associated with Thrombotic Thrombocytopenic Purpura: Case Report and Review of Literature

Cartella

Terranova

Zaccone

et al. 2022

Movement Disord Clin Pract

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Evaluation of antioxidant, anti-inflammatory, anticancer activities and molecular docking of Moringa oleifera seed oil extract against experimental model of Ehrlich ascites carcinoma in Swiss female albino mice

Aldayel,

Gad El Hak,

Nafie

et al. 2023

BMC Complement Med Ther

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The current research intended to evaluate the antitumor properties of Moringa oleifera oil extract (MOE). Fifty-six female Swiss albino mice were employed in this study. Animals were assigned into four groups: control (C) group, moringa oil extract (MOE) group administered (500 mg/kg b. wt) MOE daily via gavage, Ehrlich ascites carcinoma (EAC) group and EAC group administered daily with (500 mg/kg b.wt) MOE for two weeks (EAC/MOE). The results showed that MOE significantly ameliorated the EAC increase in body weight and reduced the EAC cell viability. In addition, they upgraded the levels of hepatic and renal functions, inflammatory cytokines, oxidative stress markers and EAC-induced hepatic and renal histopathological changes. Treatment of EAC with MOE induced antitumor, anti-inflammatory and antioxidant effects and normalized most of the tested parameters besides the histopathological alterations in both renal and hepatic tissues. HPLC for the MOE identified Cinnamic acid, Ellagic acid, Quercetin, Gallic acid, Vanillin and Hesperidin as major compounds. The molecular docking study highlighted the virtual binding of the identified compounds inside the GSH and SOD proteins, especially for Quercetin which exhibited promising binding affinity with good interactive binding mode with the key amino acids. These results demonstrate that the antitumor constituents of MOE against EAC induced oxidative stress and inflammation by preventing oxidative damage and controlling EAC increase.

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ATP-Binding Cassette Transporter of Clinical Significance: Sideroblastic Anemia

Ogunbileje,

Harris,

Wynn

et al. 2024

JPM

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The ATP-binding cassette (ABC) transporters are a vast group of 48 membrane proteins, some of which are of notable physiological and clinical importance. Some ABC transporters are involved in functions such as the transport of chloride ions, bilirubin, reproductive hormones, cholesterol, and iron. Consequently, genetic or physiological disruption in these functions is manifested in various disease processes like cystic fibrosis, Tangier disease, and sideroblastic anemia. Among other etiologies, primary sideroblastic anemia results from a genetic mutation in the ATP-binding cassette-7 (ABCB7), a member of the ABC transporter family. There are not many articles specifically tackling the disease processes caused by ABC transporters in detail. Some testing methodologies previously reported in the available literature for investigating sideroblastic anemia need updating. Here, we expound on the relevance of ABCB7 as a clinically important ABC transporter and a rare participant in the disease process of Sideroblastic anemia. The other genetic and secondary etiologies of sideroblastic anemia, which do not involve mutations in the ABCB7 protein, are also described. We review the pathophysiology, clinical course, symptoms, diagnosis, and treatment of sideroblastic anemia with a focus on modern technologies for laboratory testing.

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Movement Disorders and Hematologic Diseases

Cited by 5 publications

References 140 publications

Tremor/Myoclonus Syndrome Associated with Thrombotic Thrombocytopenic Purpura: Case Report and Review of Literature

Tremor/Myoclonus Syndrome Associated with Thrombotic Thrombocytopenic Purpura: Case Report and Review of Literature

Evaluation of antioxidant, anti-inflammatory, anticancer activities and molecular docking of Moringa oleifera seed oil extract against experimental model of Ehrlich ascites carcinoma in Swiss female albino mice

ATP-Binding Cassette Transporter of Clinical Significance: Sideroblastic Anemia

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