Movable Hollow Nanoparticles as Reactive Oxygen Scavengers

Abstract

Hemin-loaded narrow-walled mesoporous silica nanoparticles (hemin-NMSNs) as movable nanoparticles models were guided into the cells for the removal of intracellular ROS. These autonomous motions with random direction greatly enhanced the efficiency of ROS removal at low doses and alleviates safety concerns related to the potential toxicity of high doses of hemin.

In situ self-assembling Au-DNA complexes for targeted cancer bioimaging and inhibition

“…Characterization of Self-Assembled GNC-DNA Complexes. The specific tumor microenvironment (19,20) is usually exploited by in situ imaging because of the presence of relatively high amounts of molecules that act as reducing agents for GNC syntheses, such as reactive oxygen species (ROS), L-glutathione, and NADPH (21)(22)(23). In the present study, we utilized natural doublestranded DNA (dsDNA) from herring sperm (<50 bp) to explore the usage of bioresponsive self-assembled biosynthetic GNC-DNA fluorescent complexes in cancer.…”

“…In the present study, we utilized natural doublestranded DNA (dsDNA) from herring sperm (<50 bp) to explore the usage of bioresponsive self-assembled biosynthetic GNC-DNA fluorescent complexes in cancer. Based on a previously published study (19), we used a suitable concentration of gold precursor solution (20 μM pH = 7.2) without evident cytotoxicity in HeLa (cervical carcinoma), A549 (lung cancer), and L02 (normal hepatocyte) cells (SI Appendix, Fig. S1).…”

“…The use of nanotechnology and biocompatible nanomaterials to facilitate cancer diagnostics and treatments has recently been a focus on the cancer field. Among the various types of biocompatible nanomaterials (12)(13)(14)(15), gold nanoclusters (GNCs) have recently been utilized in bioimaging and other biomedical applications because of the favorable intrinsic optical characteristics, highly stable chemical properties, and good biocompatibility (16)(17)(18)(19). Based on the advantages of in situ bioresponsive biosynthetic gold nanoclusters in fluorescent imaging and therapy (20), we proposed the use of in situ self-assembled biosynthetic fluorescent gold nanocluster-DNA (GNC-DNA) complexes to facilitate accurate cancer bioimaging and targeted treatment.…”

Multifunctional peptide-assembled micelles for simultaneously reducing amyloid-β and reactive oxygen species

“…20,21 In contrast, nanomaterial-based articial enzymes such as nanoceria, mesoporous silica and carbon clusters have the ability to scavenge ROS and have been used for ROS clearance and maintaining the redox balance in the cell and preventing it from oxidative damage in vivo. [22][23][24] In comparison with natural enzymes, the nanomaterial-based articial enzymes display better stability and are much more cost-efficient. Among them, the organic nanomaterials composed of biocompatible components such as peptides are promising for AD therapy.…”

Effect of structure: A new insight into nanoparticle assemblies from inanimate to animate

“…The novel optical, electronic, magnetic, optothermal, and mechanical properties of NP assemblies are attributable to the coupling of and cooperation among individual NPs (15). NP assemblies have great potential in practical applications, such as sensing (16), energy storage (17,18), ultrastrong materials (19), biodegradable plastics (20), adsorption (21), catalysis (22), and therapies (23,24).…”