Mouthrinses and periodontal disease

Reich, Elmar; Brecx, M; Netuschil, L; Petersson, Leif

doi:10.1002/j.1875-595x.2002.tb00882.x

Cited by 16 publications

(2 citation statements)

References 62 publications

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“…As a result, adjunctive therapies have been proposed to improve the clinical and microbiological outcomes of treatments. Chemical adjunctive therapies can be achieved by different mechanisms of action, including preventing bacterial adhesion, avoiding bacterial growth/co-aggregation, eliminating an already established biofilm, and altering the pathogenicity of the biofilm [14]. Systemic antimicrobials against subgingival biofilm have been shown to affect periodontal therapy when used as adjunct therapies.…”

Section: Introductionmentioning

confidence: 99%

Statins Modulate Microenvironmental Cues Driving Macrophage Polarization in Simulated Periodontal Inflammation

Alkakhan,

Farrar,

Sikora

et al. 2023

Cells

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Periodontal disease (PD) is a chronic inflammatory disorder characterized by the destruction of connective tissue, tooth loss, and systemic infections. Clinically, treatment of PD includes control of the etiologic factors via several modalities: initial therapy including scaling and root planing (SRP), corrective phase of surgical treatment, both with and without adjunct antimicrobial/pharmacological agents, followed by a maintenance/supportive periodontal therapy phase. Each treatment phase aims to control oral biofilm by addressing risk factors and etiology. Monotherapy of systemic antibiotics is insufficient compared to their use as an adjunct to SRP. The critical issue of systemic antimicrobial usage includes adverse patient outcomes and increased bacterial resistance. Therefore, alternative adjuncts to periodontal therapy have been sought. Statins are widely prescribed for the treatment of hypercholesterolemia and cardiovascular disease. Statins have demonstrated anti-inflammatory properties and immunomodulatory effects, and a few retrospective studies showed that statin patients exhibit fewer signs of periodontal inflammation than subjects without the medication. Despite the available clinical studies on the local administration of statins for PD, no studies have reported the macrophage polarization response. We have developed a gingival fibroblast–macrophage co-culture model to track macrophage response when exposed to a battery of microenvironmental cues mimicking macrophage polarization/depolarization observed in vivo. Using our model, we demonstrate that simvastatin suppresses macrophage inflammatory response and upregulates tissue homeostasis and M2 macrophage markers. Our findings support the usage of statins to mitigate periodontal inflammation as a valid strategy.

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Section: Introductionmentioning

confidence: 99%

Statins Modulate Microenvironmental Cues Driving Macrophage Polarization in Simulated Periodontal Inflammation

Alkakhan,

Farrar,

Sikora

et al. 2023

Cells

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“…Mouthwashes have been used as a wound disinfectant, for the control of bacterial plaque and in periodontal diseases. Currently in the market there is a wide variety of mouthwashes for rinse application, mentioning among its ingredients, for example, those of phenolic composition, quaternary ammonium (1), herbal extracts, essential oils, halogen compounds among others (2).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Bacterial Growth of Streptococo Mitis Based on a Water Seed Extract From Moringa Oleifera

Flores¹,

Olmo²,

Rodriguez³

et al. 2020

IJETSI

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Brushing and flossing are the most used and accepted procedures, the "gold standard", to control bacterial plaque, but these mechanical methods have limitations. The purpose of this research was to determine the in vitro antibacterial effect of a mouthwash made with Moringa extract on Streptococcus mitis. Materials and methods: The sample consists of 74 ml of water-based moringa extract on which the antimicrobial effect of S mitis was analyzed by means of an implant in agar for 24 hours to determine a process of interruption of development of S. mitis. Results: A 5.8 cm bacterial growth inhibition halo of S. mitis was obtained with the use of the moringa aqueous extract against 6.6 cm of 0.12% chlorhexidine. Conclusion: the aqueous extract of Moringa Oleifera has an inhibition of bacterial growth with statistically favorable results, although to a lesser extent than chlorhexidine.

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Flow injection on-line dilution for zinc determination in human saliva with electrothermal atomic absorption spectrometry detection

Burguera-Pascu

Rodríguez-Archilla

Burguera

et al. 2007

Analytica Chimica Acta

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Mouthrinses and periodontal disease

Cited by 16 publications

References 62 publications

Statins Modulate Microenvironmental Cues Driving Macrophage Polarization in Simulated Periodontal Inflammation

Statins Modulate Microenvironmental Cues Driving Macrophage Polarization in Simulated Periodontal Inflammation

Inhibition of Bacterial Growth of Streptococo Mitis Based on a Water Seed Extract From Moringa Oleifera

Flow injection on-line dilution for zinc determination in human saliva with electrothermal atomic absorption spectrometry detection

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