Mouth and Genital Ulcers With Inflamed Cartilage (MAGIC Syndrome): A Case Report and Literature Review

Imai, Hirokazu; Motegi, Mutsuhito; Mizuki, Nobuhisa; Oda, Hiroshi; Komatsuda, Atsushi; Hamai, Keiko; Miura, Akira B.

doi:10.1097/00000441-199711000-00010

“…Another variant of Behçet’s syndrome that includes relapsing polychondritis, a disorder characterized by mouth and genital ulcers with inflamed cartilage, has been labeled MAGIC syndrome (Table 2) 38, 39 .…”

Section: Predisposing Etiologic Factorsmentioning

confidence: 99%

Recurrent Aphthous Stomatitis

Akintoye

¹

,

Greenberg

²

2014

Dental Clinics of North America

View full text Add to dashboard Cite

Recurrent Aphthous Stomatitis (RAS) is the most common ulcerative disease affecting the oral mucosa. It occurs mostly in healthy individuals and has atypical clinical presentation in immunocompromised individuals. The etiology of RAS is still unknown, but several local, systemic, immunologic, genetic, allergic, nutritional, and microbial factors, as well as immunosuppressive drugs, have been proposed as causative agents. Clinical management of RAS is based on severity of symptoms, frequency, size and number of lesions using topical and systemic therapies. The goals of therapy are to decrease pain and ulcer size, promote healing and decrease frequency of recurrence.

show abstract

“…Another variant of Behçet's syndrome that includes relapsing polychondritis, a disorder characterized by mouth and genital ulcers with inflamed cartilage, has been labeled MAGIC syndrome (Table 2) 38,39 .…”

Section: Underlying Medical Diseasementioning

confidence: 99%

Recurrent aphthous stomatitis

Akintoye

¹

,

Greenberg

²

2005

Dental Clinics of North America

View full text Add to dashboard Cite

Recurrent Aphthous Stomatitis (RAS) is the most common ulcerative disease affecting the oral mucosa. It occurs mostly in healthy individuals and has atypical clinical presentation in immunocompromised individuals. The etiology of RAS is still unknown, but several local, systemic, immunologic, genetic, allergic, nutritional, and microbial factors, as well as immunosuppressive drugs, have been proposed as causative agents. Clinical management of RAS is based on severity of symptoms, frequency, size and number of lesions using topical and systemic therapies. The goals of therapy are to decrease pain and ulcer size, promote healing and decrease frequency of recurrence.

show abstract

“…Posteriormente, outros autores descreveram casos isolados semelhantes, empregando o acróstico MAGIC proposto por Firestein (1) para classificá-los. Nesses casos, úlceras orogenitais e condrite auricular coexistiam com outras manifestações típicas, algumas vezes sem necessariamente preencher os critérios de classificação necessários para SB ou PR (5)(6)(7)(8)(9)(10) , assim como no caso aqui apresentado. Uma breve revisão das características clínicas desses casos é apresentada na Tabela 1.…”

Section: Discussionunclassified

“…O uso de agentes biológicos anti-TNF é descrito com sucesso em séries e relatos de casos, tanto para SB (17) como para PR (18) . A experiência terapêutica com a síndrome MAGIC se resume aos relatos de casos, com sucesso descrito para o uso de dapsona (5) e pentoxifilina (8) . Embora seja relativamente comum a associação da PR com outras doenças auto-imunes (19) , Firestein et al (1) valorizaram a existência de diversas manifestações clínicas compartilhadas entre SB e PR para sugerir a existência um mecanismo fisiopatogênico comum às duas entidades que caracterizaria a nova síndrome.…”

Section: Discussionunclassified