Mouse X Chromosome

Brown, S. D. M.; Avner, Philip; Herman, Gail E.

doi:10.1007/bf00648438

Cited by 12 publications

(2 citation statements)

References 88 publications

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“…To perform our experiments, we decided to work with YACs carrying evolutionary conserved sequences syntenic to mouse. We started with the YAC yWXD340 containing the locus DXS292 that is conserved in mouse X DNA [16, 1]. Sau 3A restriction fragments from YAC yWXD340 were incubated with the before mentioned cDNA libraries as described in Pizzuti et al [4].…”

Section: Resultsmentioning

confidence: 99%

Mapping of the MYCL2 processed gene to Xq22‐23 and identification of an additional L MYC‐related sequence in Xq27.2

et al. 1999

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We report here the identification of a human genomic sequence from the q27.2 region of the X chromosome which shows a high homology to the L-MYC proto-oncogene. This sequence is not the MYCL2 homology, previously mapped to the long arm of the X chromosome at q22-qter by Morton et al., as we located the MYCL2-processed gene in Xq22-23, using a panel containing a combination of hybrid DNA carrying different portions of the human X chromosome. Based on computer analysis, the MYC-like sequence (MYCL3) is 98.2% identical to a portion of exon 3 of the MYCL1 gene and maps to the Xq27.2 region, between the DXS312 and DXS292 loci.z 1999 Federation of European Biochemical Societies.

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Section: Resultsmentioning

confidence: 99%

Mapping of the MYCL2 processed gene to Xq22‐23 and identification of an additional L MYC‐related sequence in Xq27.2

et al. 1999

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“…Although the mouse Ube ly gene and pseudogenes are physically very close to the mouse Zfy gene in the Sxr region (Mitchell et al 1991), the mouse Ube lx gene is quite a distance from the mouse Zfx gene (-30 centiMorgans, according to Brown et al 1992). Different regions of the genome have been found to have different rates of substitution (Wolfe et al 1989).…”

Section: Discussionmentioning

confidence: 99%

Estimating the intensity of male-driven evolution in rodents by using X-linked and Y-linked Ube 1 genes and pseudogenes

Chang

1995

J Mol Evol

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Using sequence data from the last introns of ZFX and ZFY genes, we previously estimated the male-to-female ratio (alpha) of mutation rate to be close to 6 in higher primates and 1.8 in rodents. As the mutation rate may vary among different regions of the mammalian genome, it is interesting to see whether sequence data from other regions will give similar estimates. In this study, we have determined the partial genomic sequences of the ubiquitin-activating enzyme E1 genes (Ube 1x and Ube 1y for the X-linked and Y-linked homologues, respectively) of mice and rats and two mouse Ube 1y pseudogenes. From the intron sequences of the Ube 1 genes, we calculated the divergence of the Y-linked genes (Y = 0.161) and that of the X-linked genes (X = 0.107) between mouse and rat, and found the Y/X ratio to be 1.50. This ratio led to an estimate of alpha = 2.0 with a 95% confidence interval of (1.0, 3.9). Similar estimates of alpha were obtained if mouse Ube 1y pseudogenes were used instead of the mouse Ube 1y functional gene. These estimates are consistent with our previous estimate for rodents and suggest that the sex ratio of mutation rate in rodents is approximately only one-third of that in higher primates. Our estimate of the divergence time between Ube 1x and Ube 1y supports the view that the two genes separated before the eutherian radiation.

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XLPRA: A canine retinal degeneration inherited as an X‐linked trait

et al. 1994

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Breeding studies are reported of a previously undescribed hereditary retinal degeneration identified in the Siberian Husky breed of dog. This disorder clinically resembles the previously reported autosomal recessive canine hereditary retinal degenerations collectively termed progressive retinal atrophy (PRA). However, the pedigree of the propositus, a male Siberian Husky, exhibited an X-linked pattern of transmission. This dog was outcrossed to three phenotypically normal female laboratory Beagles and two of their F1 daughters were bred to a phenotypically normal male Beagle, producing affected males in the F2 generation. Subsequent inbreedings produced further affected males and affected females as well. X-linked transmission was established by exclusion of alternative modes of inheritance and, consequently, the disease has been termed X-linked progressive retinal atrophy (XLPRA). This is the first reported X-linked retinal degeneration in an animal. Because of the many similarities of PRA in dogs to retinitis pigmentosa (RP) in humans, this new disease may not only represent the first animal model of X-linked RP (XLRP) but may well be a true homolog of one of the XLRP loci (RP2, RP3, RP6). It is the first retinal degeneration in dogs that can be assigned to an identified canine chromosome, and the first for which linkage mapping offers a realistic approach to proceed by positional cloning towards identifying the responsible gene locus.

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Mouse X Chromosome

Cited by 12 publications

References 88 publications

Mapping of the MYCL2 processed gene to Xq22‐23 and identification of an additional L MYC‐related sequence in Xq27.2

Mapping of the MYCL2 processed gene to Xq22‐23 and identification of an additional L MYC‐related sequence in Xq27.2

Estimating the intensity of male-driven evolution in rodents by using X-linked and Y-linked Ube 1 genes and pseudogenes

XLPRA: A canine retinal degeneration inherited as an X‐linked trait

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