Mouse Tspyl5 promotes spermatogonia proliferation through enhancing Pcna-mediated DNA replication
Xiangyou Leng,
Shengyu Xie,
Dachang Tao
et al.
Abstract:Context The human TSPY1 (testis-specific protein, Y-linked 1) gene is critical for spermatogenesis and male fertility. However, there have been difficulties with studying the mechanism underlying its function, partly due to the presence of the Tspy1 pseudogene in mice. Aims TSPYL5 (TSPY-like 5), an autosomal homologous gene of TSPY1 showing a similar expression pattern in both human and mouse testes, is also speculated to play a role in male spermatogenesis. It is beneficial to understand the role of T… Show more
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