Mouse strains differ under a simple schedule of operant learning

Baron, Scott; Meltzer, Leonard T.

doi:10.1016/s0166-4328(00)00322-3

Cited by 37 publications

(37 citation statements)

References 23 publications

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“…We used the 2-CSSRT, a modified version of the 5-CSSRT (Bevins and Besheer, 2006), to measure attention performance. This task has been described previously and has been successfully used to analyze sustained attention in mice (Baron and Meltzer, 2001;Lee et al, 2002). It provides not only indices of attention (accuracy) but also those of executive control over performance such as premature (an index of impulsivity) and perseverative responding (compulsive behavior).…”

Section: Loss Of Ngf-trka Signaling Does Not Impair Attention Performmentioning

confidence: 99%

Loss of NGF-TrkA Signaling from the CNS Is Not Sufficient to Induce Cognitive Impairments in Young Adult or Intermediate-Aged Mice

et al. 2012

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Many molecules expressed in the CNS contribute to cognitive functions either by modulating neuronal activity or by mediating neuronal trophic support and/or connectivity. An ongoing discussion is whether signaling of nerve growth factor (NGF) through its high-affinity receptor TrkA contributes to attention behavior and/or learning and memory, based on its expression in relevant regions of the CNS such as the hippocampus, cerebral cortex, amygdala and basal forebrain. Previous animal models carrying either a null allele or transgenic manipulation of Ngf or Trka have proved difficult in addressing this question. To overcome this problem, we conditionally deleted Ngf or Trka from the CNS. Our findings confirm that NGF-TrkA signaling supports survival of only a small proportion of cholinergic neurons during development; however, this signaling is not required for trophic support or connectivity of the remaining basal forebrain cholinergic neurons. Moreover, comprehensive behavioral analysis of young adult and intermediate-aged mice lacking NGF-TrkA signaling demonstrates that this signaling is dispensable for both attention behavior and various aspects of learning and memory.

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Section: Loss Of Ngf-trka Signaling Does Not Impair Attention Performmentioning

confidence: 99%

Loss of NGF-TrkA Signaling from the CNS Is Not Sufficient to Induce Cognitive Impairments in Young Adult or Intermediate-Aged Mice

et al. 2012

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“…The use of operant methods with positive reinforcement contingencies has been relatively neglected in mouse behavioral genetics and neuroscience (Mihalick, Langlois, Krienke, & Dube, 2000). One factor hindering the widespread adoption of these methods is the presumed difficulty of establishing such behavior (Baron & Meltzer, 2001; see, e.g., Crawley, 2000, pp. 114-119).…”

Section: ____________________________________________________________mentioning

confidence: 99%

“…The purpose of the present study was to establish operant lever pressing (as distinct from nose poking) in mice using a modified version of the automated procedure described by Baron and Meltzer (2001). To our knowledge, there have been no published reports demonstrating that operant lever pressing can be established in various types of inbred mice within two 120-min training sessions.…”

Section: ____________________________________________________________mentioning

confidence: 99%

Differential Acquisition of Lever Pressing in Inbred and Outbred Mice: Comparison of One-Lever and Two-Lever Procedures and Correlation With Differences in Locomotor Activity

McKerchar

Zarcone

Fowler

2005

Journal of the Experimental Analysis of Behavior

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Recent progress in mouse genetics has led to an increased interest in developing procedures for assessing mouse behavior, but relatively few of the behavioral procedures developed involve positively reinforced operant behavior. When operant methods are used, nose poking, not lever pressing, is the target response. In the current study differential acquisition of milk-reinforced lever pressing was observed in five inbred strains (C57BL/6J, DBA/2J, 129X1/SvJ, C3H/HeJ, and BALB/cJ) and one outbred stock (CD-1) of mice. Regardless of whether one or two levers (an ''operative'' and ''inoperative'' lever) were in the operant chamber, a concomitant variable-time fixed-ratio schedule of milk reinforcement established lever pressing in the majority of mice within two 120-min sessions. Substantial differences in lever pressing were observed across mice and between procedures. Adding an inoperative lever retarded acquisition in C57BL/6J, DBA/2J, 129X1/SvJ, and C3H/HeJ mice, but not in CD-1 and BALB/cJ mice. Locomotor activity was positively correlated with number of lever presses in both procedures. Analyses of durations of the subcomponents (e.g., time to move from hopper to lever) of operant behavior revealed further differences among the six types of mice. Together, the data suggest that appetitively reinforced lever pressing can be acquired rapidly in mice and that a combination of procedural, behavioral, and genetic variables contributes to this acquisition.

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The literature on humans lacking the CC points to mild, language-related deficits in intelligence and rhyming [10,24], and it suggests that deficits are most likely to appear on motor tasks, in which pressure exists to perform at high speed [14,23].

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confidence: 92%

Wheel running behavior is impaired by both surgical section and genetic absence of the mouse corpus callosum

Schalomon

Wahłsten

2002

Brain Research Bulletin

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These results are not totally conclusive because the strains in question also show a number of behavioral peculiarities that are unrelated to the effects of an absent CC [2,18,20,26], and it remains possible that effects of absent CC may depend on the strain background, just as CC absence does [22]. The present paper addresses this limitation by utilizing several recombinant inbred lines created from the 129 and BALB/c strains, so that genes responsible for absence of the CC would not likely be spuriously correlated with genes relevant for abnormal behavior.The literature on humans lacking the CC points to mild, language-related deficits in intelligence and rhyming [10,24], and it suggests that deficits are most likely to appear on motor tasks, in which pressure exists to perform at high speed [14,23]. In this paper, we report that CC-related deficits in high-speed wheel running indeed appear when the task is rendered more difficult by removing several rungs from the wheel.The interpretation of behavioral test results from acallosal mice is challenging because usually no compelling reason exists to believe that the behaviors in question rely heavily on interhemispheric communication. It is also possible that as with human CC agenesis [9,11,19,29], developmental plasticity creates or pre-serves alternative

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Mouse strains differ under a simple schedule of operant learning

Cited by 37 publications

References 23 publications

Loss of NGF-TrkA Signaling from the CNS Is Not Sufficient to Induce Cognitive Impairments in Young Adult or Intermediate-Aged Mice

Loss of NGF-TrkA Signaling from the CNS Is Not Sufficient to Induce Cognitive Impairments in Young Adult or Intermediate-Aged Mice

Differential Acquisition of Lever Pressing in Inbred and Outbred Mice: Comparison of One-Lever and Two-Lever Procedures and Correlation With Differences in Locomotor Activity

Wheel running behavior is impaired by both surgical section and genetic absence of the mouse corpus callosum

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