1982
DOI: 10.1128/iai.35.1.240-247.1982
|View full text |Cite
|
Sign up to set email alerts
|

Mouse protection assay for group B streptococcus type III

Abstract: The mucin model for group B Streptococcus (GBS) type III was used to assay the protective effect of sera against a type III challenge in mice. Hyperimmune rabbit sera, prepared by the Lancefield method against the laboratory reference strain (SS620) and a clinical isolate (M732), protected against a lethal challenge with either strain of GBS type III. Absorption of the sera with either of these type III strains removed the protective effect. Neither normal rabbit sera nor heterologous antisera (anti-Ia, SS615)… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
6
0

Year Published

1983
1983
2023
2023

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 18 publications
(6 citation statements)
references
References 18 publications
0
6
0
Order By: Relevance
“…Absence of the latter drastically reduces or abolishes GBS killing by phagocytes [8]. Type-specific antibodies maximize phagocytosis and killing when complement is present, and protect against infection both in human and experimental models when they are present in sufficent concentrations in sera [1,2,[34][35][36].…”
Section: Discussionmentioning
confidence: 99%
“…Absence of the latter drastically reduces or abolishes GBS killing by phagocytes [8]. Type-specific antibodies maximize phagocytosis and killing when complement is present, and protect against infection both in human and experimental models when they are present in sufficent concentrations in sera [1,2,[34][35][36].…”
Section: Discussionmentioning
confidence: 99%
“…However, immune human sera or heterologous antisera have not been described as possessing cross-protective activity against infections caused by GBS with different capsule types. Typically, GBS antisera raised by immunization with one serotype are protective only against infections caused by GBS with homologous capsule types (2,5,10,28). Thus it is reasonable to assume that either cross-protective group B antibodies are not generated by active immunization, or if present, their activity is below detectable levels .…”
Section: Discussionmentioning
confidence: 99%
“…Male C3H/HeN mice, 13-wk-old and ~30 g, were obtained from the National Cancer Institute. The mucin model of Fleming (9,10) was used in all experiments. A 10% (wt/vol) suspension of type II hog gastric mucin (Sigma Chemical Co.) in Dulbecco's balanced salt solution was prepared and autoclaved.…”
Section: Methodsmentioning
confidence: 99%