2006
DOI: 10.1074/jbc.m602840200
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Mouse Ornithine Decarboxylase-like Gene Encodes an Antizyme Inhibitor Devoid of Ornithine and Arginine Decarboxylating Activity

Abstract: Ornithine decarboxylase (ODC), a key enzyme in the biosynthesis of polyamines, is a labile protein that is regulated by interacting with antizymes (AZs), a family of polyamine-induced proteins. Recently, a novel human gene highly homologous to ODC, termed ODC-like or ODC-paralogue (ODCp), was cloned, but the studies aimed to determine its function rendered contradictory results. We have cloned the mouse orthologue of human ODCp and studied its expression and possible function. mRNA of mouse Odcp was found in t… Show more

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Cited by 57 publications
(91 citation statements)
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“…These findings corroborate our previous claim that ODCp or ODC-like acts as an antizyme inhibitor, not only because it binds to the three antizymes and stimulates ODC activity (29) but also by negating the repressing effect of any of the three antizymes on polyamine uptake. Moreover, the fact that the deletion in AZIN2 of the sequence equivalent to the antizyme binding domain, existing in mouse ODC (37) and in AZIN1 (38,39), abolished the stimulatory effect of AZIN2 on polyamine uptake also supports that this domain is critical for the binding of AZIN2 to the antizyme molecule.…”
Section: Discussionsupporting
confidence: 81%
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“…These findings corroborate our previous claim that ODCp or ODC-like acts as an antizyme inhibitor, not only because it binds to the three antizymes and stimulates ODC activity (29) but also by negating the repressing effect of any of the three antizymes on polyamine uptake. Moreover, the fact that the deletion in AZIN2 of the sequence equivalent to the antizyme binding domain, existing in mouse ODC (37) and in AZIN1 (38,39), abolished the stimulatory effect of AZIN2 on polyamine uptake also supports that this domain is critical for the binding of AZIN2 to the antizyme molecule.…”
Section: Discussionsupporting
confidence: 81%
“…These results have later been corroborated for human ODCp by others (30). AZIN2/ODCp is mainly expressed in testes and brain both in mice and human (29,31), and by both functional and co-immunoprecipitation experiments, we demonstrate that this protein is able to interact with the three antizyme isoforms as is also shown for the former antizyme inhibitor, the AZIN1 (32). As stated above, AZ3 is a testis-specific protein that is believed to participate in the maintenance of appropriate levels of polyamines during spermiogenesis (22).…”
supporting
confidence: 64%
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