Mouse nerve growth factor promotes neurological recovery in patients with acute intracerebral hemorrhage: A proof-of-concept study

An, Shuo; Jia, Ying; Tian, Ye; Sun, Jian; Wei, Yingsheng; Yue, Shuyuan; Lin, Lijuan; Wei, Yongyue; Li, Ying; Lei, Ping; Zhang, Jianning; Jiang, Rongcai

doi:10.1016/j.jns.2020.117069

Cited by 6 publications

(2 citation statements)

References 27 publications

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“…Exogenous fibrin-binding domain fused BDNF is observed to concentrate in the perihematomal area and to promote neural regeneration with ameliorated neurological deficits [165]. Moreover, there is a proof-of-concept study that administration of mouse nerve growth factor improves 3 month functional recovery compared to citicoline controls in patients with spontaneous ICH [166].…”

Section: Strategies To Promote Neural Regeneration After Ich 61 Medicationsmentioning

confidence: 99%

Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier

Zhang

Xue

Yong

2021

Cells

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Despite marked advances in surgical techniques and understanding of secondary brain injury mechanisms, the prognosis of intracerebral hemorrhage (ICH) remains devastating. Harnessing and promoting the regenerative potential of the central nervous system may improve the outcomes of patients with hemorrhagic stroke, but approaches are still in their infancy. In this review, we discuss the regenerative phenomena occurring in animal models and human ICH, provide results related to cellular and molecular mechanisms of the repair process including by microglia, and review potential methods to promote tissue regeneration in ICH. We aim to stimulate research involving tissue restoration after ICH.

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Section: Strategies To Promote Neural Regeneration After Ich 61 Medicationsmentioning

confidence: 99%

Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier

Zhang

Xue

Yong

2021

Cells

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“…mNGF is a common medicine for nerve injury treatment (Li JT et al 2022). Some researchers reported that mNGF was effective in treating CNS injury and developmental disorder in children (An S et al 2020). Furthermore, this study aimed to analyze the effect of hUC-MSC-exos and their combination with mNGF on the CP in mice and its mechanism.…”

Section: Introductionmentioning

confidence: 99%

Human umbilical cord mesenchymal stem cell-derived exosomes improve brain tissue and functional recovery in mice with cerebral palsy

Chen

Sai

Cui

et al. 2023

Preprint

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Cerebral palsy (CP) is a neurodevelopmental and motor disorder syndrome threatening children’s physical and mental health. Hypoxic-ischemic brain injury and inflammation have been considered as the main causes of CP. Mesenchymal stem cells (MSCs) can repair brain tissue damage, and many studies have proved that exosomes from MSCs have a critical advantage in the central nervous system (CNS) disease. Therefore, this study aimed to explore the improvement effect of human umbilical cord MSC (hUC-MSC)-derived exosomes on CP and whether synergistic action existed when combined with mouse nerve growth factor (mNGF). Therefore, the exosomes were isolated from hUC-MSCs and examined using electron microscopy, particle size, and Western blot (WB). A CP model was constructed by hypoxic induction after unilateral common carotid artery ligation combined with lipopolysaccharide (LPS) infection. The pathological damage of neuron tissue and synaptic structure in the hippocampus was determined using a light microscope after hematoxylin-eosin (HE) staining and transmission electron microscopy, respectively. The survival of neurons was analyzed using Nissl staining. The WB analysis was performed to monitor postsynaptic density 95(PSD-95) and synaptophysin(SYN) protein levels. The results showed that exosomes released by hUC-MSCs could ameliorate the motor function in mice with CP by rescuing the impaired brain tissue, synaptic structure, and neuronal function with increased PSD-95 and SYN levels. When the exosome was combined with mNGF, an improvement in CP was found. The results indicated that the intravenously injected hUC-MSC-exosomes and intraperitoneal administration of mNGF alleviated the nerve function injury in mice with CP.

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Safety, Tolerability, Pharmacokinetics, and Immunogenicity of a Novel Recombination Human Nerve Growth Factor in Healthy Chinese Subjects

Shen

Zhang²,

Jin³

et al. 2023

CNS Drugs

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Mouse nerve growth factor promotes neurological recovery in patients with acute intracerebral hemorrhage: A proof-of-concept study

Cited by 6 publications

References 27 publications

Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier

Central Nervous System Tissue Regeneration after Intracerebral Hemorrhage: The Next Frontier

Human umbilical cord mesenchymal stem cell-derived exosomes improve brain tissue and functional recovery in mice with cerebral palsy

Safety, Tolerability, Pharmacokinetics, and Immunogenicity of a Novel Recombination Human Nerve Growth Factor in Healthy Chinese Subjects

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