“…However, the model was not stable as the findings from bone pathology were inconsistent with those from bone micro-CT three-dimensional reconstruction. Moreover, mice are small animals with a limited blood volume and a high mortality rate [ 14 ]. An adenine diet (0.2% adenine + 1.8% phosphorus) has been demonstrated to induce rapid and remarkable changes in the alveolar bone of CKD mice, including enamel loss, increased dentin, decreased pulp, and severe alveolar bone resorption [ 18 ].…”