Mouse Models of Mayaro Virus

Rosa, Rafael Borges; de Castro, Emilene Ferreira; de Oliveira Santos, Débora; da Silva, Murilo Vieira; Pena, Lindomar José

doi:10.3390/v15091803

Cited by 3 publications

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We observed a similar pattern in the children's age groups, since there was an overall reduction in hospitalizations of children, but with signifi cant increase in mortality in the age groups from 1 to 4 years old and from 10 to 14 years old. The reduction in hospitalization rates could be seen as a sign that the COVID-19 infection has less repercussions in children, as seen in previous reports [38]. Nevertheless, the increase in mortality evidenced in the aforementioned age groups makes additional studies necessary.…”

Section: Discussionmentioning

confidence: 59%

The Impact of COVID-19 Pandemic on Cardiovascular Diseases in Brazil

NL Lopes,

da Silva,

Carvalho

et al. 2023

J Biomed Res Environ Sci

View full text Add to dashboard Cite

Background: The novel coronavirus pandemic is an international public health emergency due to the high contagious potential of the virus on a global scale and, similarly to what happened globally, Brazilian authorities took measures to reduce its impact on the healthcare system, including social distancing. In this context of exhaustion of the system, it is worth questioning the situation of patients who need medical care for other diseases, such as the cardiovascular ones. Objectives: Describe the changes in the epidemiological profile of hospitalizations cardiovascular diseases during the COVID-19 pandemic in Brazil. Methods: Assessment of relative variations on the number of hospitalizations, associated average time, mortality rate and financial investments. Results: After the beginning of the pandemic, there was reduction of 21.46% in hospitalizations, more accentuated in females and in the Northern region, and increase of 14.14% in mortality, of greater significance in the Midwestern region. In younger ages, mortality and permanence time presented more accentuated positive variations. In elective admissions, growth in mortality and in hospital expenses were more significant. Conclusion: The pandemic impacted on cardiovascular diseases in a multifactorial way. The number of hospitalizations decreased, and the mortality rate increased, as efforts concentrated on moderate and severe cases. Therefore, there is a need for policies that minimize mid- and long-term impacts, as well as studies that investigate possible late complications of infections by the novel coronavirus.

show abstract

Section: Discussionmentioning

confidence: 59%

The Impact of COVID-19 Pandemic on Cardiovascular Diseases in Brazil

NL Lopes,

da Silva,

Carvalho

et al. 2023

J Biomed Res Environ Sci

View full text Add to dashboard Cite

show abstract

Applications and advancements in animal models for antiviral research on mosquito‐borne arboviruses

Tang,

Wong,

Azman

et al. 2024

Anim Models and Exp Med

View full text Add to dashboard Cite

Vector‐borne diseases caused by arthropod‐borne viruses (arboviruses) are a considerable challenge to public health globally. Mosquito‐borne arboviruses, such as Chikungunya, Dengue, and Zika viruses, cause a range of human illnesses and may be fatal. Currently, efforts to control these diseases still face challenges due to growing vector resistance towards insecticides, urbanization, and limited effective antiviral treatments and vaccines. Animal models are crucial in antiviral research on mosquito‐borne arboviruses, playing a role in understanding disease mechanisms, vaccine development, and toxicity testing, but the application of animal models still faces the challenges of ethical considerations and animal‐to‐human translational success. Genetically engineered mouse models, hamster models and non‐human primate (NHP) are currently used in arbovirus research, but new models such as tree shrews and novel humanized mice are emerging. In the context of Malaysian research, the use of long‐tailed macaques as potential NHP models for arbovirus research is possible; however, it faces the ethical dilemma of using an endangered species for scientific purposes. Overall, animal models play a crucial role in advancing infectious disease research, but a balance between medical research and species conservation must be upheld.

show abstract

Activating FcγRs on monocytes are necessary for optimal Mayaro virus clearance

Dunagan,

Dábilla,

McNinch

et al. 2024

Preprint

View full text Add to dashboard Cite

Mayaro virus (MAYV) is an emerging arbovirus. Previous studies have shown antibody Fc effector functions are critical for optimal monoclonal antibody-mediated protection against alphaviruses; however, the requirement of Fc gamma receptors (FcγRs) for protection during natural infection has not been evaluated. Here, we showed mice lacking activating FcγRs (FcRγ-/-) developed prolonged clinical disease with more virus in joint-associated tissues. Viral clearance was associated with anti-MAYV cell surface binding rather than neutralizing antibodies. Lack of Fc-FcγR engagement increased the number of monocytes through chronic timepoints. Single cell RNA sequencing showed elevated levels of pro-inflammatory monocytes in joint-associated tissue with increased MAYV RNA present in FcRγ-/- monocytes and macrophages. Transfer of FcRγ-/- monocytes into wild type animals was sufficient to increase virus in joint-associated tissue. Overall, this study suggests that engagement of antibody Fc with activating FcγRs promotes protective responses during MAYV infection and prevents monocytes from being potential targets of infection.

show abstract

Mouse Models of Mayaro Virus

Cited by 3 publications

References 39 publications

The Impact of COVID-19 Pandemic on Cardiovascular Diseases in Brazil

The Impact of COVID-19 Pandemic on Cardiovascular Diseases in Brazil

Applications and advancements in animal models for antiviral research on mosquito‐borne arboviruses

Activating FcγRs on monocytes are necessary for optimal Mayaro virus clearance

Contact Info

Product

Resources

About