Mouse mast cells as anti-tumor effector cells

Farram, E; Nelson, David S.

doi:10.1016/0008-8749(80)90162-8

Cited by 88 publications

(28 citation statements)

References 11 publications

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“…In general, peripheral distribution of mast cells around an experimentally induced tumour has been recognized as playing a protective role against the tumours (Farram and Nelson, 1980;Tanooka et al, 1982;Burtin et al, 1985). In these tumours, mast cells and their degranulation products (histamine, serotonin and heparin) have been reported to be involved in tumour inhibition (Tharp et al, 1989;Benyon et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

“…The role of mast cells in tumour growth has been studied extensively in experimental tumours (Fisher and Fisher, 1965;Tanooka et al, 1982;Burtin et al, 1985), however, the significance of mast cell infiltration around human tumours has not been well studied, even though accumulation of mast cells around tumours was first reported a decade ago (Dimitriadou and Koutsilieris, 1997). Most studies have shown that mast cells prevent tumour growth (Farram and Nelson, 1980;Henderson et al, 1981;Ghiara et al, 1985;Benyon et al, 1991). In contrast, in a heterocyclic amine-induced rat PCa model, Nakai et al (2007) reported increased infiltration of stromal mast cell in the ventral prostate, with increased prostatic epithelial proliferation, suggesting that mast cells may have beneficial roles in progression of PCa (Nakai et al, 2007).…”

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confidence: 99%

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Decreased number of mast cells infiltrating into needle biopsy specimens leads to a better prognosis of prostate cancer

et al. 2007

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Mast cell infiltration is often observed around human tumours. Inflammatory cells such as macrophages, neutrophils and mast cells infiltrating around tumours are known to contribute to tumour growth; however, the clinical significance of mast cell invasion in prostate cancer (PCa) has not been investigated. Mast cell infiltration was evaluated in 104 patients (age range, 45 -88 years; median, 72 years), who underwent needle biopsy of the prostate and were confirmed to have PCa. Needle biopsy specimens of prostate were sliced into 5-mm-thick sections and immunostained for mast cells with monoclonal antibody against mast cell-specific tryptase. Mast cells were counted systematically under a microscope ( Â 400 magnification), and the relations between mast cell numbers and clinicopathologic findings were evaluated. The mast cell count was evaluated for prognostic value by multivariate analysis. Mast cells were immunostained around the cancer foci. The median number of mast cells in each case was 16. The mast cell count was higher around cancer foci in patients with higher Gleason scores than in those with low Gleason scores. The mast cell number correlated well with clinical stage (Po0.001). Prostate-specific antigen-free survival of patients with higher mast cell counts was better than that in patients with lower mast cell counts (Po0.001). Multivariate analysis revealed that mast cell count was a significant prognostic factor (Po0.005). The number of mast cells infiltrating around cancer foci in prostate biopsy specimens can be a significant prognostic factor of PCa.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Decreased number of mast cells infiltrating into needle biopsy specimens leads to a better prognosis of prostate cancer

et al. 2007

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“…Several studies have suggested a protective role for mast cells against tumours. For instance mouse mast cells were reported to be cytotoxic to mouse artd rat fibrosarcomas (Farram & Nelson, 1980) and the growth of pulmonary metastases of B16 melanoma was observed in mast cell-free mice but not in normal mice ((Schitteck et al, 1985). Similarly an inverse correlation between tumour incidence and tissue histamine levels was reported for fibrosarcomas and Lewis lung carcinomas (Burtin et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

Mast cells and matrix degradation at sites of tumour invasion in rat mammary adenocarcinoma

Dabbous¹,

Walker²,

Haney³

et al. 1986

Br J Cancer

111

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Summary Significant numbers of mast cells have been demonstrated histologically around the periphery of the invasive rat mammary adenocarcinoma 13672NF. The number of mast cells at microfoci along the tumour:host tissue junction was significantly greater than that found in normal mammary tissues, and few mast cells were detected within the tumour itself. Mast cell degranulation, often associated with disruption and lysis of the connective tissue matrix, was a common feature in later stages of tumour proliferation. When soluble products derived from purified rat peritoneal mast cells were added to monolayer cultures of rat stromal fibroblasts or tumour cells they stimulated a significant increase in total collagenase production, and the mast cell products were also capable of activating the latent collagenases thus produced. Histological examination indicated that degradation of local collagenous matrix was a common feature of mast cell degranulation, an observation possibly explained by the release of mast cell enzymes and/or the potential of this cell to modulate the expression of collagenolytic activity by surrounding cells. These observations suggest that, at least in some tumours, mast cells contribute to the connective tissue breakdown commonly associated with tumour invasiveness and metastatic spread.

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“…None of the antihistaminics (both anti-Hi and anti-H2) caused any reduction in cytotoxicity. In contrast, reserpine blocked tumour killing, suggesting serotonin as the principal agent of tumour-cell killing in mice (Farram et al, 1980). Furthermore, the endogenous peroxidase activity of peritoneal mastcell granules has been shown in vitro to be toxic to mammalian tumour cells, when combined with H202 and iodide (Henderson etal., 1981).…”

Section: Discussionmentioning

confidence: 99%

Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: Influence of H1 and H2 histamine receptors

Burtin¹,

Scheinmann²,

Salomon³

et al. 1982

Br J Cancer

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Summary.-C3H and C57 BL/6 mice carrying methylcholanthrene-induced fibrosarcomas were injected i.p. daily with histamine, metiamide (anti-histamine type-2 receptor), histamine + metiamide, mepyramine (anti-histamine type-i receptor), serotonin and methysergide (anti-serotonin). Inhibition of tumour growth and lengthened survival were observed with histamine and histamine+ metiamide. The best results (both on tumour growth and survival) were obtained with serotonin. Survival was increased by metiamide and decreased by mepyramine and methysergide. In histamine-treated and in serotonin-treated mice, histological studies of the tumours showed large and numerous foci of haemorrhagic necrosis.Stimulation of histamine type-I or serotonin receptors and inhibition of histamine type-2 receptors play a beneficial role in the host's defence against tumours.

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Mouse mast cells as anti-tumor effector cells

Cited by 88 publications

References 11 publications

Decreased number of mast cells infiltrating into needle biopsy specimens leads to a better prognosis of prostate cancer

Decreased number of mast cells infiltrating into needle biopsy specimens leads to a better prognosis of prostate cancer

Mast cells and matrix degradation at sites of tumour invasion in rat mammary adenocarcinoma

Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: Influence of H1 and H2 histamine receptors

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