Mouse Mammary Tumor Virus

Dudley, Jacquelin

doi:10.1016/b978-012374410-4.00445-3

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…The effect of Rev on the MMTV-based luciferase vector also was determined in HC11 mouse mammary cells since breast epithelial cells are permissive for MMTV replication [ 34 ]. Rem gave a 4 to 5-fold increase in HC11 cells and was dependent on the presence of the RmRE (Figure 3A ), whereas Rev gave no detectable effect in the presence or absence of the response element.…”

Section: Resultsmentioning

confidence: 99%

“…RNA-binding proteins appear to regulate several steps following transcription, leading to coordinated regulation of cellular RNAs with related functions called RNA regulons [ 81 ]. MMTV replication in the mouse requires several different cell types, including lymphocytes and mammary epithelial cells [ 34 ]. We previously have shown that MMTV replication is controlled at the transcriptional level during mammary gland development coordinately with several milk-specific genes [ 82 , 83 ].…”

Section: Discussionmentioning

confidence: 99%

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Rev and Rex proteins of human complex retroviruses function with the MMTV Rem-responsive element

2009

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Background: Mouse mammary tumor virus (MMTV) encodes the Rem protein, an HIV Rev-like protein that enhances nuclear export of unspliced viral RNA in rodent cells. We have shown that Rem is expressed from a doubly spliced RNA, typical of complex retroviruses. Several recent reports indicate that MMTV can infect human cells, suggesting that MMTV might interact with human retroviruses, such as human immunodeficiency virus (HIV), human T-cell leukemia virus (HTLV), and human endogenous retrovirus type K (HERV-K). In this report, we test whether the export/regulatory proteins of human complex retroviruses will increase expression from vectors containing the Rem-responsive element (RmRE).

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rev and Rex proteins of human complex retroviruses function with the MMTV Rem-responsive element

2009

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Of Mice and Women: A Short History of Mouse Mammary Cancer Research with an Emphasis on the Paradigms Inspired by the Transplantation Method

Medina¹

2010

Cold Spring Harbor Perspectives in Biology

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The ability to transplant mammary epithelial cells of any age or developmental stage to the normal anatomical site of an inbred recipient mouse strain has revolutionized the studies of mammary development and tumor biology over the past 50 years. This simple method has made the mammary gland of the rodent one of the most accessible and studied organs and facilitated our understanding of the fundamental cellular and molecular properties of normal and neoplastic development. This short review outlines the early concepts that led to the development of the transplantation technology and the impact of this method on our understanding for a variety of processes important both for the normal development and differentiation of the gland as well as the phenomena of neoplastic progression.

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Mouse Mammary Tumor Virus

Cited by 2 publications

References 11 publications

Rev and Rex proteins of human complex retroviruses function with the MMTV Rem-responsive element

Rev and Rex proteins of human complex retroviruses function with the MMTV Rem-responsive element

Of Mice and Women: A Short History of Mouse Mammary Cancer Research with an Emphasis on the Paradigms Inspired by the Transplantation Method

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