Mouse histocompatibility genes: structure and organisation of a Kd gene.

Kvist, Sune; Roberts, Larry E.; Dobberstein, Bernhard

doi:10.1002/j.1460-2075.1983.tb01413.x

Cited by 170 publications

(94 citation statements)

References 51 publications

(73 reference statements)

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“…Although all class I major histocompatibility complex genes and products share substantial sequence homology and overall biochemical properties, a number of features differentiate members of this family (13,28). Alleles of the K, D, and L genes, the products of which function as restriction-recognition molecules, are highly diverse (13,28).…”

Section: Discussionmentioning

confidence: 99%

“…Alleles of the K, D, and L genes, the products of which function as restriction-recognition molecules, are highly diverse (13,28). Alleles of the Qa and TL genes exhibit much more conservation of sequence (20,48).…”

Section: Discussionmentioning

confidence: 99%

“…Sequence analyses of various alleles of the K, D, and L loci indicate that loci and alleles differ equally from each other by approximately 20% over the 200 amino-terminal amino acids and by 11% on the corresponding nucleotide level (8,13,28,43). This large diversity among alleles is in sharp contrast to that observed at other genetic loci, where alleles usually differ from one another by only a few amino acids.…”

mentioning

confidence: 80%

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Interaction between Kb and Q4 gene sequences generates the Kbm6 mutation.

Geliebter¹,

Zeff²,

Schulze³

et al. 1986

Mol. Cell. Biol.

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Genetic interaction as a mechanism for the generation of mutations is suggested by recurrent (12,39).From serological studies of the K and D antigens in laboratory and wild mouse populations it has been estimated that greater than 50 alleles of each exist, attesting to the tremendous polymorphism of these loci (11). Sequence analyses of various alleles of the K, D, and L loci indicate that loci and alleles differ equally from each other by approximately 20% over the 200 amino-terminal amino acids and by 11% on the corresponding nucleotide level (8,13,28,43). This large diversity among alleles is in sharp contrast to that observed at other genetic loci, where alleles usually differ from one another by only a few amino acids. This diversity is also remarkable with regard to the high conservation of Qa-and TL-region genes and their protein products, since limited tryptic peptide and DNA sequencing analyses indicate that alleles in these regions exhibit consid-* Corresponding author. t Present address:

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 80%

See 1 more Smart Citation

Interaction between Kb and Q4 gene sequences generates the Kbm6 mutation.

Geliebter¹,

Zeff²,

Schulze³

et al. 1986

Mol. Cell. Biol.

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“…The differently sized primary translation products of the microvillar enzymes and their individual regulation in the intestine during embryonic development may be a promise of more individuality of these enzymes as far as their gene organization and regulation are concerned. Here, inspiration may come from other eukaryotic plasma membrane proteins like the H-2 Kd antigen (Kvist et al, 1983), where the coding sequences for the cytoplasmic domain, the membrane spanning segment, the three extracellular domains and the signal sequence were found on separate exons on the gene.…”

Section: Discussionmentioning

confidence: 99%

Biosynthesis of microvillar proteins

Danielsen¹,

Cowell²,

Norén³

et al. 1984

Biochemical Journal

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“…The H-2Kd gene and the H-2Kk gene have been characterized extensively (8,9). The construction of hybrid genes, plasmids pC31, pC32, and pC33, from the H-2Kd and H-2Kk genes has been described in detail recently (7).…”

Section: Methodsmentioning

confidence: 99%

Alloreactive cytolytic T-cell clones preferentially recognize conformational determinants on histocompatibility antigens: analysis with genetically engineered hybrid antigens.

Arnold¹,

Horstmann²,

Kuon³

et al. 1985

Proc. Natl. Acad. Sci. U.S.A.

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Hybrid genes were constructed for the localization of allodeterminants on murine class I antigens recognized by antibodies and cytol ytic T lymphocytes. By using deletion subclones of the H12K and H-2Kk genes, homologous regions were exchanged between the two alleles. The altered genes were introduced and expressed in mouse fibroblast and fibrosarcoma cells. Cells expressing hybrid antigens were analyzed with 29 monoclonal anti-H-2Kd and anti-H-2Kk antibodies and with 150 short-term alloreactive cytolytic T-cell clones. When only the first or only the second amino-terminal domain was exchanged, most T cells and 60% of the antibodies lost their reactivity to the H-2K antigen. No T-cell clone was directed against the third extracellular domain, whereas three antibodies could bind to this domain. This implies that nearly all determinants essential for a cytolytic T-cell response or for antibody binding lie on the two external domains and are conformational structures generated by the interaction of these two domains.

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Mouse histocompatibility genes: structure and organisation of a Kd gene.

Abstract: The gene coding for the mouse H-2Kd antigen has been isolated by using a K-locus specific cDNA probe.

Cited by 170 publications

References 51 publications

Interaction between Kb and Q4 gene sequences generates the Kbm6 mutation.

Interaction between Kb and Q4 gene sequences generates the Kbm6 mutation.

Biosynthesis of microvillar proteins

Alloreactive cytolytic T-cell clones preferentially recognize conformational determinants on histocompatibility antigens: analysis with genetically engineered hybrid antigens.

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