2008
DOI: 10.1038/nature07066
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Mouse development with a single E2F activator

Abstract: The E2F family is conserved from C. elegans to mammals with some family members having transcription activation functions and others having repressor functions 1, 2 . Whereas C. elegans 3 and Drosophila melanogaster 4, 5 have a single E2F activator and repressor proteins, mammals evolved to have at least three activator and five repressor proteins 1,2,6 . Why such genetic complexity evolved in mammals is not known. To begin to evaluate this genetic complexity, we targeted the inactivation of the entire subset … Show more

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Cited by 89 publications
(107 citation statements)
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“…3j). E2F3 has been shown to be sufficient for cell proliferation and normal embryonic and post-natal development [38][39][40] , thus explaining the observed cell cycle progression despite the downregulation of E2F1 by Salmonella.…”
Section: Discussionmentioning
confidence: 98%
“…3j). E2F3 has been shown to be sufficient for cell proliferation and normal embryonic and post-natal development [38][39][40] , thus explaining the observed cell cycle progression despite the downregulation of E2F1 by Salmonella.…”
Section: Discussionmentioning
confidence: 98%
“…The fact that knockdown of E2F3 does not affect promoter activity to the same extent as EWSR1/FLI1 silencing (Fig. 4A) may be explained by functional redundancy among co-expressed E2F family members (Tsai et al 2008).…”
Section: E2f/ets Regulatory Module In Ets-driven Cancersmentioning
confidence: 93%
“…Germline E2f3a-and E2f3b-deficient mice were generated originally by GL and were maintained on an FVB/N background. 8,54 All cells used in this study were cultured as neurospheres. Neural precursors were obtained by dissection of the ganglionic eminence from developing embryos at gestational age E14.5, and cells were cultured as neurospheres as previously described.…”
Section: Methodsmentioning
confidence: 99%