Mouse Chromosome 7

Rinchik, Eugene M.; Magnuson, Terry; Holdener-Kenny, Bernadette; Kelsey, Gavin; Bianchi, A.; Conti, Claudio J.; Chartier, Fran�ois; Brown, K. J.; Brown, S. D. M.; Peters, Josephine

doi:10.1007/bf00648425

Cited by 27 publications

(7 citation statements)

References 183 publications

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“…ID: sequence identi®cation numbers were obtained from GenBank. Chr (cM): chromosome number and distance in centimorgans from the centromere (Love et al, 1990;Rinchik et al, 1992;Buchberg et al, 1992 …”

Section: Quantifying Dnamentioning

confidence: 99%

A region within murine chromosome 7F4, syntenic to the human 11q13 amplicon, is frequently amplified in 4NQO-induced oral cavity tumors>

1997

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Section: Quantifying Dnamentioning

confidence: 99%

A region within murine chromosome 7F4, syntenic to the human 11q13 amplicon, is frequently amplified in 4NQO-induced oral cavity tumors>

1997

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“…In addition, tauroursodeoxycholic acid, which is used in the treatment of cholestatic liver disease, is known to stimulate biliary secretion of bile acids through Ca 2ϩ -dependent PKC activation (26). Furthermore, PKC␤ (chromosome 7, 117.5 Mb, 61.0 centimorgans) is a positional candidate for the Lith22 gene that was detected on chromosome 7 with peak linkage at 60 centimorgans (27,28). The potential effects of PKC␤ on insulin signaling, obesity, cholesterol, and TG homeostasis led us to hypothesize that PKC␤ may modify the pathogenesis of diet-induced gallstone formation.…”

mentioning

confidence: 99%

Disruption of the Murine Protein Kinase Cβ Gene Promotes Gallstone Formation and Alters Biliary Lipid and Hepatic Cholesterol Metabolism

Huang¹,

Bansode

Rowland

et al. 2011

Journal of Biological Chemistry

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The protein kinase C (PKC) family of Ca 2؉ and/or lipid-activated serine-threonine protein kinases is implicated in the pathogenesis of obesity and insulin resistance. We recently reported that protein kinase C␤ (PKC␤), a calcium-, diacylglycerol-, and phospholipid-dependent kinase, is critical for maintaining whole body triglyceride homeostasis. We now report that PKC␤ deficiency has profound effects on murine hepatic cholesterol metabolism, including hypersensitivity to diet-induced gallstone formation. The incidence of gallstones increased from 9% in control mice to 95% in PKC␤ ؊/؊ mice. Gallstone formation in the mutant mice was accompanied by hyposecretion of bile acids with no alteration in fecal bile acid excretion, increased biliary cholesterol saturation and hydrophobicity indices, as well as hepatic p42/44 MAPK activation, all of which enhance susceptibility to gallstone formation. Lithogenic diet-fed PKC␤ ؊/؊ mice also displayed decreased expression of hepatic cholesterol-7␣-hydroxylase (CYP7A1) and sterol 12␣-hydroxylase (CYP8b1). Finally, feeding a modified lithogenic diet supplemented with milk fat, instead of cocoa butter, both increased the severity of and shortened the interval for gallstone formation in PKC␤ ؊/؊ mice and was associated with dramatic increases in cholesterol saturation and hydrophobicity indices. Taken together, the findings reveal a hitherto unrecognized role of PKC␤ in fine tuning diet-induced cholesterol and bile acid homeostasis, thus identifying PKC␤ as a major physiological regulator of both triglyceride and cholesterol homeostasis.

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“…Alternative arrangements of the loci result in a minimum of six progeny that would have double crossover events between flanking loci. Since Hbb has been previously mapped centromeric to H19 which is itself centromeric to Int-2 (Rinchik et al 1992), the order of the loci examined was determined to be centromere-Hbb -mCdl9 -H19 -Int-2 -telomere. The genetic distances between mCd19 and the flanking loci were calculated from the recombination frequencies localizing mCdl9 to a central position 13.5+4.7 cM from Hbb and 11.5 +4.4 cM from HI9 and Int-2 (Table 3).…”

Section: Resultsmentioning

confidence: 99%

“…Within this region lies a portion of mouse chromosome 7 homologous to the region of human chromosome 16 to which hCD19 was mapped. In addition to CD 19, multiple loci expressed by leukocytes map within these conserved regions in both humans and mice, including the interleukin-4 receptor (16p12.1-pll.2; Suzuki et al 1991), CD43 (Ly-48, leukosialin; 16pl 1.2; Baecher et al 1990), and protein kinase C beta polypeptide (16p12-pll.1; Rinchik et al 1992). This region also contains the genes encoding the leukocyte adhesion receptors CD 11 a (Ly 15, LFA-1, 16p 13.1-p 11), CD 1 lb, and CD1 lc (Hogarth et al 1986;Corbi et al 1988).…”

Section: Discussionmentioning

confidence: 99%

CD19 maps to a region of conservation between human chromosome 16 and mouse chromosome 7

et al. 1994

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CD19 is a B lymphocyte cell surface protein expressed from the earliest stages of B lymphocyte development until their terminal differentiation into plasma cells. In this report the human CD19 gene (hCD19) was localized to band p11.2 on the proximal short arm of chromosome 16 by in situ hybridization to metaphase chromosomes, using hCD19 cDNA as probe. hCD19 gene localization was confirmed by polymerase chain reaction based analysis with hCD19-specific primers, using a panel of human/hamster somatic cell hybrid DNA as templates. The mouse CD19 gene (mCd19) was mapped to bands F3-F4 of chromosome 7 by in situ hybridization to metaphase chromosomes, using a mCD19 cDNA probe. Segregation analysis of nucleotide sequence polymorphisms in interspecific backcross progeny revealed linkage of mCd19 with hemoglobin beta (Hbb), Int-2, and H19, other loci previously mapped to the same region of mouse chromosome 7, confirming the localization of mCd19 to this region. The order of these loci was determined to be centromere--Hbb--mCd19--H19--Int-2--telomere. The genetic distances between the loci examined, calculated from the recombination frequencies, suggested that mCd19 was located centrally between Hbb and H19. This region of mouse chromosome 7 is homologous to the region of human chromosome 16 to which the hCD19 gene maps. Multiple genes with a lymphocyte-related function also map to this conserved region including genes encoding the IL-4 receptor, CD11a, CD11b, CD11c, CD43 (leukosialin), and protein kinase C beta polypeptide.

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Mouse Chromosome 7

Cited by 27 publications

References 183 publications

A region within murine chromosome 7F4, syntenic to the human 11q13 amplicon, is frequently amplified in 4NQO-induced oral cavity tumors>

A region within murine chromosome 7F4, syntenic to the human 11q13 amplicon, is frequently amplified in 4NQO-induced oral cavity tumors>

Disruption of the Murine Protein Kinase Cβ Gene Promotes Gallstone Formation and Alters Biliary Lipid and Hepatic Cholesterol Metabolism

CD19 maps to a region of conservation between human chromosome 16 and mouse chromosome 7

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