Mouse Chromosome 6

Elliott, Rosemary W.; Moore, Karen J.

doi:10.1007/bf00648424

Cited by 9 publications

(2 citation statements)

References 193 publications

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“…In the mouse, the N K C is linked to several unrelated genes, including Kap and Igkc (56). R F L P analysis revealed a similar linkage in the rat.…”

Section: Mapping Of the Rat Nkc And Localization To Chromosomementioning

confidence: 85%

An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes.

Dissen

Ryan

Seaman

et al. 1996

The Journal of Experimental Medicine

110

102

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SummaryNatural Killer (NK) cells can recognize and kill MHC-incompatible normal bone marrowderived cells. Presently characterized MHC-binding receptors on NK cells, including the Ly-49 family in the mouse, transmit inhibitory signals upon binding to cognate class I MHC ligands. Here we study in vivo NK-mediated lysis of normal allogeneic lymphocytes in crosses between alloreactivity-competent PVG rats and alloreactivity-deficient DA rats. NK cells from both strains are able to lyse standard tumor targets. We identify an autosomal dominant locus, Nka, that controls NK-mediated alloreactivity. Individuals carrying the dominant PVG allele in single dose were fully competent in eliminating anogeneic target cells, suggesting that Nka encodes or regulates a gene product inducing or activating alloreactivity. By linkage analysis and pulsed field gel electrophoresis, a natural killer gene complex (NKC) on rat chromosome 4 is described that contains the rat NKR-P1 and Ly-49 multigene families plus a rat NKG2D homologue. Nka maps within the NKC, together with the most telomeric Ly-49 family members, but separate from NKG2D and the NKR-P1 family. The Nka-encoded response, moreover, correlates with the expression of transcripts for Ly-49 receptors in NK cell populations, as Northern blot analysis demonstrated low expression of Ly-49 genes in DANK cells, in contrast to high expression in alloreactivity-competent PVG, (DA • PVG)F1, and PVG.1AV1 NK cells. The low Ly-49 expression in DA is not induced by MHC haplotype, as demonstrated by high expression of Ly-49 in the DA MHC-congenic PVG.1AV1 strain. Finally, we have cloned and characterized the first four members of the rat Ly-49 gene family. Their cytoplasmic domains demonstrate substantial heterogeneity, consistent with the hypothesis that different Ly-49 family members may subserve different signaling functions.

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“…In the mouse, the N K C is linked to several unrelated genes, including Kap and Igkc (56). R F L P analysis revealed a similar linkage in the rat.…”

Section: Mapping Of the Rat Nkc And Localization To Chromosomementioning

confidence: 85%

An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes.

Dissen

Ryan

Seaman

et al. 1996

The Journal of Experimental Medicine

110

102

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“…genes located in the same region. These genes include Igk, Ly-2, Ly-3, 11-Sr [gene encoding interleukin 5 receptor], Ly-35, Ly4, and Tnfr-2 [gene encoding tumor necrosis factor (Tnf) receptor 21 (35,36). At present, our mapping data are inadequate to identify which, if any, of these candidate genes is related to the Bphs locus.…”

mentioning

confidence: 97%

Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6.

Sudweeks

Todd

Blankenhorn

et al. 1993

Proc. Natl. Acad. Sci. U.S.A.

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Pertussis toxin (PTX) is the primary component responsible for eliciting the majority ofbiological activities associated with Bordetella pertussis, including the induction of several tissue-adjuvant models of organ-specific autoimmune disease. PTX, when administered in vivo, enhances vascular permeability, which is made manifest by a concomitant increase in sensitivity to a variety of agents and treatments affecting the vascular bed. One such agent is histamine, and the response to PTX, as measured by hypersensitivity following vasoactive amine challenge, is genetically controlled by the Bphs locus. Susceptibility to the induction of both experimental allergic encephalomyelitis (EAE) and experimental allergic orchitis (EAO) in mice is associated with, and in the latter case linked to, a susceptible allele at this locus. We report here the mapping of the Bphs locus to mouse chromosome 6, telomeric of Tcrb and centromeric of Prp (D6Nds8). This region also contains a number of loci of immunologic relevance including Igk, Ly-2, Ly-3, ll-5r, Ly-35, Ly-4, and Tnfr-2.

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The murine Spam1 gene: RNA expression pattern and lower steady-state levels associated with the Rb(6.16) translocation

Ying

Martin‐DeLeon

1997

Mol. Reprod. Dev.

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Mouse Chromosome 6

Cited by 9 publications

References 193 publications

An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes.

An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes.

Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6.

The murine Spam1 gene: RNA expression pattern and lower steady-state levels associated with the Rb(6.16) translocation

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