Mouse Basophils Reside in Extracellular Matrix-Enriched Bone Marrow Niches Which Control Their Motility

Smaniotto, Salete; Schneider, Elke; Bricard-Rignault, Rachel; Machavoine, François; Dardenne, Mireille; Dy, Michel; Savino, Wilson

doi:10.1371/journal.pone.0070292

Cited by 3 publications

(2 citation statements)

References 22 publications

(23 reference statements)

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“…Laminins promote adhesion of basophils [71,72] and eosinophils [73,74] via integrin α6β1 in vitro . Adhesion of eosinophils favors their viability.…”

Section: Laminins and Immune System Interactionsmentioning

confidence: 99%

Regulation of the Immune System by Laminins

Thézenas

Bromberg

2017

Trends in Immunology

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Laminins are trimeric proteins that are major components of the basement membranes that separate endothelia and epithelia from the underlying tissue. Sixteen laminin isoforms have been described, each with distinct tissue expression patterns and functions. While laminins have a critical structural role, recent evidence also indicates that they also impact the migration and functions of immune cells. Laminins are differentially expressed upon immunity or tolerance and orientate the immune response. This review will summarize the structure of laminins, the modulation of their expression, and their interactions with the immune system. Finally, the role of the laminins in autoimmune diseases and transplantation will be discussed.

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“…Laminins promote adhesion of basophils [71,72] and eosinophils [73,74] via integrin α6β1 in vitro . Adhesion of eosinophils favors their viability.…”

Section: Laminins and Immune System Interactionsmentioning

confidence: 99%

Regulation of the Immune System by Laminins

Thézenas

Bromberg

2017

Trends in Immunology

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“…Among the chemokine receptors which basophils are able to express are CCR1, CCR2, CCR3, CXCR2 and CXCR4, and these receptors can be expressed in different combinations dependent on their activation status [42,43]. Basophils express several integrins including Mac-1, VLA-4, and VLA-2 (α 2 β 1 /CD49b CD29), which binds to collagens and other ECM proteins [44]. Blocking β 1 and β 2 integrins inhibited transendothelial migration of human basophils in vitro [45].…”

Section: Tissue Recruitment Of Granulocytes During Inflammationmentioning

confidence: 99%

Granulocyte development, tissue recruitment, and function during allergic inflammation

Radtke

Voehringer

2023

Eur J Immunol

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Granulocytes provide a fast innate response to pathogens and allergens. In allergy and anti-helminth immunity, epithelial cells of damaged barriers release alarmins like IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) but also chemokines like CXCL1 or CCL11 to promote cell recruitment and inflammation. In addition, mast cells positioned at barrier tissue sites also quickly release mediators upon specifically sensing antigens through IgE bound to FcεR1 on their surface. Released mediators induce the recruitment of different granulocytes in a timely ordered manner. First, neutrophils extravasate from the blood vasculature to the side of alarmin release and promote a potent inflammatory response. Alarmins and activated mast cells further promote activation of ILC2s and recruitment of basophils and eosinophils, which inhibit neutrophil recruitment and enhance tissue type 2 immunity. In addition to their potent pro-inflammatory effector functions, granulocytes can also contribute to termination and resolution of inflammation. Here, we summarize the development and tissue recruitment of granulocyte subsets, and describe general effector functions and aspects of their increasingly appreciated role in limiting tissue damage. We further discuss targeting approaches for therapeutic interventions in allergic disorders.

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The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control

Malara

Abbonante

Buduo

et al. 2015

Cell. Mol. Life Sci.

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SUMMARY Megakaryocytes are rare cells found in the bone marrow, responsible for the everyday production and release of millions of platelets into the bloodstream. Since the discovery and cloning, in 1994, of their principal humoral factor, thrombopoietin, and its receptor c-Mpl, many efforts have been directed to define the mechanisms underlying an efficient platelet production. However, more recently different studies have pointed out new roles for megakaryocytes as regulators of bone marrow homeostasis and physiology. In this review we discuss the interaction and the reciprocal regulation of megakaryocytes with the different cellular and extracellular components of the bone marrow environment. Finally, we provide evidence that these processes may concur to the reconstitution of the bone marrow environment after injury and their deregulation may lead to the development of a series of inherited or acquired pathologies.

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Mouse Basophils Reside in Extracellular Matrix-Enriched Bone Marrow Niches Which Control Their Motility

Cited by 3 publications

References 22 publications

Regulation of the Immune System by Laminins

Regulation of the Immune System by Laminins

Granulocyte development, tissue recruitment, and function during allergic inflammation

The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control

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