Mouse Adenovirus

Otten, J. A.; Tennant, Raymond W.

doi:10.1016/b978-0-12-262502-2.50023-7

Cited by 2 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…What is not clear from our results :is why MAdV-FL has all but disappeared as a naturally occurring infection of laboratory mice (10). Very little virus is required to infect the mouse, and the virus retains infectivity under environmental conditions for long periods of time (11).…”

mentioning

confidence: 79%

Factors influencing susceptibility of laboratory rodents to infection with mouse adenovirus strains K87 and FL

Smith

Barthold

1987

Archives of Virology

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 79%

Factors influencing susceptibility of laboratory rodents to infection with mouse adenovirus strains K87 and FL

Smith

Barthold

1987

Archives of Virology

View full text Add to dashboard Cite

show abstract

“…and MAV-2 infects the gastrointestinal tract (35). However, MAV-1 has been partially sequenced and found not to have an E3 region similar to those of most of the human Ads (40), and our attempts to place the human Ad E3 region into the truncated MAV-1 "E3" region have not been successful.…”

Section: E3a E3bmentioning

confidence: 99%

“…In addition, the E3 promoter is inducible in liver, which is the site of the Reye syndrome pathology that we have previously demonstrated after MAV-1 infection in SCID animals (36). Constitutive E3 expression in the intestine should be very useful for studies of MAV-2 pathogenesis, since this virus is an intestinal pathogen, as well as of MAV-1, because the intestine is probably the portal of entry (35). The effects of the E3 genes can now be measured both in suckling animals that undergo acute and fatal disease and in adult mice that have less acute disease but develop persistent infection, especially of the urinary tract.…”

mentioning

confidence: 94%

Characterization of transgenic mice containing adenovirus early region 3 genomic DNA

Fejér

Győry

Tufariello

et al. 1994

J Virol

View full text Add to dashboard Cite

Human adenoviruses (Ad) contain a complex transcription region (E3) which codes for proteins that interact with several arms of the immune system. However, E3 genes are not essential for replication in tissue culture. An E3-encoded 19,000-molecular-weight (19K) glycoprotein (gpl9K) binds to the class I major histocompatibility complex (MHC) in the endoplasmic reticulum and prevents MHC transport to the cell surface. Three other E3 proteins are involved in the inhibition of apoptosis by tumor necrosis factor alpha. The entire E3 genomic DNA was utilized to produce transgenic mice to study the effect of the E3 proteins on pathogenesis of various infectious agents and to investigate the in vivo synthesis and processing of the multiple E3 mRNAs and proteins. There was basal expression of the E3 promoter in the thymus, kidneys, uterus, and testes and at all levels of the gastrointestinal tract. In addition, the E3 promoter of the transgene could be activated in some other organs, including the liver, by infection of these animals with an E3-deficient Ad (Ad7001) which contains a functional EIA region. Transactivation in vivo could also be demonstrated by infusion of bacterial lipopolysaccharide. There appeared to be differential ratios of expression between several of the E3 mRNAs in transgenic lung fibroblasts and primary kidney cells cultured from the transgenic animals. This observation suggested that there was differential mRNA splicing that was organ specific. These transgenic animals should provide a useful model for studying the effects of the E3 proteins on the immune system and on diseases affected either by control of MHC or by selected functions of tumor necrosis factor that are inhibitable by Ad E3 proteins.

show abstract

Mouse Adenovirus

Cited by 2 publications

References 34 publications

Factors influencing susceptibility of laboratory rodents to infection with mouse adenovirus strains K87 and FL

Factors influencing susceptibility of laboratory rodents to infection with mouse adenovirus strains K87 and FL

Characterization of transgenic mice containing adenovirus early region 3 genomic DNA

Contact Info

Product

Resources

About