Mouriri elliptica: Validation of gastroprotective, healing and anti-Helicobacter pylori effects

Moleiro, Fábio Cruz; Andréo, Márcio Adriano; Santos, Raquel de Cássia dos; Moraes, Thiago de Mello; Rodrigues, Clenilson Martins; Carli, Camila Bernardes de Andrade; Lopes, Flávia Cristine Mascia; Pellizzon, Cláudia Helena; Carlos, Iracilda Zeppone; Bauab, Taís Maria; Vilegas, Wagner; Hiruma-Lima, Clélia Akiko

doi:10.1016/j.jep.2009.03.040

Cited by 35 publications

(26 citation statements)

References 42 publications

(43 reference statements)

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“…Diversos estudos sobre atividade biológica de plantas medicinais contendo taninos e flavonoides evidenciaram dentre outras ações a cura de feridas, atividades antiinflamatória, antiulcerogênica gástrica e antioxidante (Kushima et al, 2009;Moleiro et al, 2009). Taninos podem interagir com as proteínas do muco, melhorando seu efeito citoprotetor pela formação de um revestimento proteico na mucosa gastrintestinal (Okuda, 2005;Moleiro et al, 2009).…”

Section: Resultsunclassified

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A etnobotânica aplicada à úlcera gástrica e avaliação farmacológica de Solanum stipulaceum

et al. 2017

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ResumoO saber popular sobre plantas medicinais tem auxiliado estratégias de bioprospecção de espécies e direcionado o estudo para a descoberta de novas atividades farmacológicas. O objetivo desta pesquisa foi identificar espécies medicinais utilizadas contra úlcera gástrica pela comunidade do Povoado Vila Capim, Arapiraca, Alagoas e, avaliar a atividade antiulcerogênica gástrica da espécie mais saliente. Para a seleção dos informantes-chave utilizou-se a técnica da bola de neve e aplicadas entrevistas semiestruturadas. A análise das falas foi pela técnica do Discurso do Sujeito Coletivo. Para os testes farmacológicos foram utilizados ratos Wistar machos no modelo de lesão gástrica aguda induzida por etanol absoluto. A toxicidade aguda foi avaliada. Dezessete informantes-chave indicaram os sintomas e plantas medicinais utilizadas contra a úlcera gástrica. A espécie com maior valor de saliência foi a Solanum stipulaceum (sacatinga), escolhida para testes químicos e farmacológicos. O extrato aquoso bruto (SSaq) apresentou atividade significativa na dose de 200 mg kg -1 (p<0,05), sendo capaz de inibir lesões (91,35%). O extrato etanólico (SSet) demonstrou atividade gastroprotetora nas doses de 200 e 400 mg kg -1 (p<0.01), com inibição de 71,12% e 76,38%, respectivamente. É necessário aprofundar os estudos para a elucidação dos compostos químicos das folhas da espécie, toxicologia e identificação dos mecanismos de ação subjacentes à atividade gastroprotetora de S. stipulaceum.Palavras-chave: Plantas medicinais, bioprospecção, análise de saliência, ensaios in vivo. Applied ethnobotany to gastric ulcer and pharmacological evaluation of Solanum stipulaceum AbstractThe popular knowledge about medicinal plants has helped the bioprospecting strategies of species and directed to a discovery of new pharmacological activities. The aim of this study was to identify medicinal species used against gastric ulcer in the Vila Capim village, Arapiraca, Alagoas, and it evaluating a gastric anti -inflammatory activity of the most salient species. For a selection of key informants has used a snowball technique. The TCLE was signed and semi-structured interviews were applied. The analysis of the speeches was done on the Discourse of the Collective Subject technique. For pharmacological experimental tests, plant extract was underwent the Acute Gastric Lesion Model induced by absolute ethanol and using Wistar male rats. Acute toxicity was evaluated. Seventeen key informants indicated the symptoms and the medicinal plants used against gastric ulcer. The species with the highest salience value was Solanum stipulaceum Roem & Schult (sacatinga), chosen for chemical and pharmacological tests. The crude aqueous extract (SSaq) presented significant activity at a dose of 200 mg kg -1 (p<0.05), being able to inhibit lesions (91.35%). Ethanolic extract (SSet) showed gastroprotective activity at doses of 200 and 400 mg kg -1 (p <0.01), with inhibition of (71.12% and 76.38%), respectively. Further studies will be need for analysis of toxicit y and id...

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Section: Resultsunclassified

“…Taninos podem interagir com as proteínas do muco, melhorando seu efeito citoprotetor pela formação de um revestimento proteico na mucosa gastrintestinal (Okuda, 2005;Moleiro et al, 2009). Porém estes efeitos protetores dependem da dose e do tipo de tanino.…”

Section: Resultsunclassified

A etnobotânica aplicada à úlcera gástrica e avaliação farmacológica de Solanum stipulaceum

et al. 2017

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“…Phenolic compounds, which include tannins and flavonoids, are apparently related to the interesting anti-inflammatory, woundhealing, antioxidant and antiulcerogenic properties to several medicinal plants (Moleiro et al, 2009). Tannins are potent scavengers of peroxyl radicals and can also interact with mucus proteins, improving their cytoprotective effect by forming a protein lining over the gastrointestinal mucosa (Okuda, 2005;Moleiro et al, 2009).…”

Section: Natural Products Used In Treating Gastritismentioning

confidence: 99%

“…Tannins are potent scavengers of peroxyl radicals and can also interact with mucus proteins, improving their cytoprotective effect by forming a protein lining over the gastrointestinal mucosa (Okuda, 2005;Moleiro et al, 2009). Fresh fruit and vegetables have been reported to exert multiple biological effects on the mucosa of the gastrointestinal tract due to their antioxidant contents (La Vecchia & Tavani, 1998).…”

Section: Natural Products Used In Treating Gastritismentioning

confidence: 99%

“…Several medicinal plants including species of the Brazilian Cerrado biome as well as plants of the "Caatinga" biome contain phenolic compounds like tannins and flavonoids that have anti-inflammatory, antioxidant and antiulcerogenic properties (Almeida et al, 2005;Moleiro et al, 2009). Catechins (flavan-3-ols) such as catechin, epicatechin, epigallocatechin, epicatechin gallate and epigallocatechin gallate, are particularly a b u n d a n t i n t h e b a r k o f t h e s p e c i e s o f Mimosaceae family (Santos et al, 2002).…”

Section: Abarema Cochliacarposmentioning

confidence: 99%

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Role of Natural Antioxidants in Gastritis

Elseweidy¹

2011

Gastritis and Gastric Cancer - New Insights in Gastroprotection, Diagnosis and Treatments

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Herbal medicines to the treatment of skin and soft tissue infections: advantages of the multi‐targets action

Amparo

Seibert

Vieira

et al. 2019

Phytotherapy Research

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The research for new treatments of skin and soft tissue infections (SSTIs) is important due to their high prevalence and number of hospitalizations. The purpose of this review is to address the pathophysiology of SSTIs to highlight the advantages of herbal medicines to their treatment, showing examples of species and compounds with multi‐targets action. SSTIs have a complex physiopathology involving the microorganism, as well as inflammation and difficult healing. Therefore, antimicrobial, anti‐inflammatory, antioxidant and healing activities are an approach possible for their treatment. Herbal medicines have a wide diversity of biological compounds, mainly phenolic compounds that may act on different targets and also have synergism between them. Therefore, a single medicine may have the four key activities that allied allow eliminating the infection, control the inflammation process and accelerating the healing process, preventing complications with chronic infections.

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Mouriri elliptica: Validation of gastroprotective, healing and anti-Helicobacter pylori effects

Cited by 35 publications

References 42 publications

A etnobotânica aplicada à úlcera gástrica e avaliação farmacológica de Solanum stipulaceum

A etnobotânica aplicada à úlcera gástrica e avaliação farmacológica de Solanum stipulaceum

Role of Natural Antioxidants in Gastritis

Herbal medicines to the treatment of skin and soft tissue infections: advantages of the multi‐targets action

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