Motorized 0.8-mm micropunch grafting for refractory vitiligo: A retrospective study of 230 cases

Bae, Jung Min; Lee, Ji Hae; Kwon, Hyuck Sun; Kim, Jiehoon; Kim, Do Kyung

doi:10.1016/j.jaad.2018.06.016

Cited by 23 publications

(29 citation statements)

References 21 publications

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“…In our comparative split‐body trial, we found no significant difference in final repigmentation between the epidermal and dermal orientation groups. The overall results were also comparable to those of our prior study using motorized 0.8‐mm micropunch grafting 11 . Furthermore, the occurrence of adverse events, including a cobblestone appearance, was less frequent with the SST than in the prior report, although our findings may be influenced by the small sample size in the present study and differences in the postoperative follow‐up periods between studies.…”

Section: Discussionsupporting

confidence: 87%

“…It has often been noted that punch grafting is time‐consuming and less efficient, and that it involves a risk of cobblestoning. However, the introduction of motorized 0.8‐mm micropunch grafting has remarkably reduced the procedure time and improved the final outcome while minimizing the incidence of cobblestoning 11 . Nevertheless, a smaller graft size can cause difficulty in ensuring implantation in the correct orientation with the unaided eyes.…”

Section: Introductionmentioning

confidence: 99%

“…However, the introduction of motorized 0.8-mm micropunch grafting has remarkably reduced the procedure time and improved the final outcome while minimizing the incidence of cobblestoning. 11 Nevertheless, a smaller graft size can cause difficulty in ensuring implantation in the correct orientation with the unaided eyes. Therefore, we developed a new surgical technique using motorized 0.5-mm micropunch grafting that allows implantation regardless of the orientation, thus saving time and effort.…”

Section: Introductionmentioning

confidence: 99%

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Skin seeding technique with 0.5‐mm micropunch grafting for vitiligo irrespective of the epidermal–dermal orientation: Animal and clinical studies

Kim¹,

Lee

et al. 2020

The Journal of Dermatology

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Micropunch grafting is the simplest surgical intervention for refractory vitiligo but is tedious and time-consuming. Therefore, we aimed to verify the efficacy and safety of dermal orientation grafting using motorized 0.5-mm micropunch grafting for vitiligo. In a preliminary animal study, 12-week-old rats were used to observe the healing process after the transplantation of dermal orientation grafts with various punch sizes. In a clinical trial, a total of 100 vitiligo patches in 50 patients with stable vitiligo were randomly allocated to motorized 0.5-mm micropunch grafting in epidermal and dermal orientations, respectively. The grafts were implanted at intervals of 5 mm at the recipient site. Treatment success was defined as greater than 75% repigmentation. In the animal study, all grafts were shown to be well integrated into the recipient site within 3 weeks. In the clinical trial, treatment success was achieved in 72% and 76% of the epidermal and dermal orientation groups, respectively; a cobblestone appearance was observed in 4% and 2%, respectively. In conclusion, we demonstrated that this new grafting method irrespective of epidermal-dermal orientation using motorized 0.5-mm micropunch grafting was effective and safe. We have named this the "skin seeding technique" and it differs from traditional punch grafting in that it can be performed regardless of the graft orientation.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Skin seeding technique with 0.5‐mm micropunch grafting for vitiligo irrespective of the epidermal–dermal orientation: Animal and clinical studies

Kim¹,

Lee

et al. 2020

The Journal of Dermatology

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“…Although PG is time‐consuming and associated with a risk of cobblestoning, it is simple and appropriate for small vitiligo lesions. Furthermore, the introduction of motorized 0.8‐mm micropunch grafting has overcome the limitations mentioned above 63 . SBG is one of the most effective surgical interventions, but is tedious and thus confined to small or medium‐sized lesions 62 .…”

Section: Resultsmentioning

confidence: 99%

Development of evidence‐based consensus on critical issues in the management of patients with vitiligo: A modified Delphi study

Bae

Jeong

Choi

et al. 2020

Photoderm Photoimm Photomed

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Background/purpose: Vitiligo remains a major challenge in dermatology. However, much of the treatment remains unclear, because little evidence is available. We sought to answer some critical questions pertaining to management of vitiligo patients. Methods: A modified Delphi process among 31 vitiligo experts was conducted. A total of 12 clinical vitiligo treatment questions without clear answers were collected How to cite this article: Bae JM, Jeong K-H, Choi CW, et al.

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“…4 However, not all vitiligo lesions respond to the conventional treatments; 5 acral vitiligo (which is very noticeable) especially is often resistant to even surgical interventions. 6 Camouflage may be a viable alternative for patients with refractory vitiligo that has not responded to surgical intervention, and for those who are not candidates for surgical intervention. Medical camouflaging agents include skin-colored paint, dihydroxyacetone solutions and micropigmentation; each has unique advantages and disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Micropigmentation for vitiligo on light to moderately colored skin: Updated evidence from a clinical and animal study

Eun

Lee

et al. 2020

The Journal of Dermatology

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Micropigmentation, also termed medical tattooing, can be a useful alternative treatment for patients with vitiligo who are resistant to conventional treatments. To assess the benefits and risks of micropigmentation in the treatment of refractory vitiligo, 25 lesions of 14 patients with vitiligo (Fitzpatrick skin types III and IV) were subjected to micropigmentation using an electric tattooing machine between December 2018 and March 2019. The procedure was repeated until satisfactory results were obtained. Treatment response was assessed by color matching of the treated lesion and surrounding skin using a 4-point scale (poor, fair, good and excellent). Excellent color matching was achieved in 80% (20/25) of cases after a median of three (range, 1-5) treatment sessions. Procedure-associated pain was considerable, but no anesthetic injection was needed. Immediate erythema and swelling were noticed after each procedure, but resolved within a few days. Overall, the treatment was tolerable. This study was limited by a small sample, no control group and a short follow-up period. This study revealed that micropigmentation was beneficial for patients with refractory vitiligo who had light to moderately colored skin. Pigment selection, implantation depth and selection of body parts amenable to treatment were critical.

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Motorized 0.8-mm micropunch grafting for refractory vitiligo: A retrospective study of 230 cases

Cited by 23 publications

References 21 publications

Skin seeding technique with 0.5‐mm micropunch grafting for vitiligo irrespective of the epidermal–dermal orientation: Animal and clinical studies

Skin seeding technique with 0.5‐mm micropunch grafting for vitiligo irrespective of the epidermal–dermal orientation: Animal and clinical studies

Development of evidence‐based consensus on critical issues in the management of patients with vitiligo: A modified Delphi study

Micropigmentation for vitiligo on light to moderately colored skin: Updated evidence from a clinical and animal study

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