Motoric cognitive risk syndrome: Prevalence and cognitive performance

Abstract

Introduction: : Cognitive decline and dementia have a significant impact on the quality of life of older adults and their caregivers. Increasing and optimizing accessibility of clinical dementia risk assessment is important to set up preventive measures and reduce health care costs. Motoric Cognitive Risk Syndrome (MCRS) is a pre-dementia stage where slow gait speed and subjective memory complaints are present, but where cognitive performance is adequate and without functional impairment. In addition to dementia, MCRS seems to increase the risk of having other geriatric outcomes including frailty, disability, falls and overall mortality. Methods: Data from the SABE Colombia study (Health, Well-Being, and Aging) conducted in 2015 in community-dwelling adults aged 60 years and older. Using the 4 aspects considered within the MCRS definition, we evaluated the presence of this syndrome and factors associated in this population with regression models. A sub-sample of 19,004 participants was obtained. Results:The multivariate analysis showed a prevalence of 5,45% of MCRS. After adjusting for cofounding variables MCRS was associated with MMSE (OR 0.90, CI 0.82-0.99; p 0.028) and frailty (

The prevalence and co-existence of geriatric syndromes in older patients with dementia compared to those without dementia

“…2 The number of geriatric syndromes according to the presence of dementia geriatric syndromes, especially sarcopenia, are also strongly associated with frailty [25]. Slow walking and involuntary weight loss that begin years before the diagnosis of dementia, are important components of frailty [26].This shows that frailty may trigger the underlying mechanisms bringing about the onset of dementia, which increases the vulnerability of the individual to the disease [25]. Although the mechanisms underlying these associations are not yet clear, oxidative stress and inflammation are suggested to play a role [25].…”