Motor Unit Number Estimation in Neuromuscular Disease

Rashidipour, Omid; Chan, K. Ming

doi:10.1017/s0317167100008568

Cited by 25 publications

(20 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Electromyography and motor unit number estimation play an important role in detecting LMNs and are regarded to be the most accurate confirmatory tests for ALS, but these techniques cannot evaluate disease development or the effects of treatment [6,7]. For the UMNs, neuroimaging techniques are a promising way to diagnose ALS or evaluate disease progression, and these techniques include conventional MRI, DTI, MRS and functional MRI [8].…”

Section: Discussionmentioning

confidence: 99%

Role of diffusion tensor imaging or magnetic resonance spectroscopy in the diagnosis and disability assessment of amyotrophic lateral sclerosis

Liu¹,

Jiang²,

Yi³

et al. 2015

Journal of the Neurological Sciences

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Role of diffusion tensor imaging or magnetic resonance spectroscopy in the diagnosis and disability assessment of amyotrophic lateral sclerosis

Liu¹,

Jiang²,

Yi³

et al. 2015

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…The temporal development of neuronal cell damage in the spinal cord in the acute infection followed by the chronic infection is reminiscent in some ways of ALS and poliomyelitis. The motor units consisting of cell bodies, axons, and the muscle fibers are diminished, probably due to cell body damage followed by axonal degeneration (30). Suppression of MUNE was coincident with the presence of WNV-induced neuropathology, whereas MUNE was not suppressed in hamsters infected with yellow fever virus or Punta Toro virus, which cause nonneurological diseases.…”

mentioning

confidence: 96%

“…The loss of motor neurons is detected in other neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) (30,36) and poliomyelitis (25), by using electrophysiological motor unit number estimation (MUNE) (5), in which a motor unit consists of an ␣-motor neuron and all the muscle fibers it innervates. A presumptive use of MUNE in the human WNV infection was identified in an uncontrolled clinical study (2) in which MUNE appeared to be a marker for degrees of weakness and recovery in patients with neurological sequelae.…”

mentioning

confidence: 99%

“…During this later stage of infection, the motor neurons and their associated axons possessing either WNV or its proteins are dysfunctional, which causes suppressed MUNE and paralysis or muscle weakness. Since these neuronal cells survive, compensatory axonal sprouting from adjacent healthy axons (30) will not replace the dysfunctional axons, so both suppressed MUNE and muscle weakness may persist in some patients. The correlate to this hypothesis is that neurological sequelae might be reduced if the viral load is reduced by innate or acquired immunity or by antiviral therapy in the longterm phase of the disease.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Persistent West Nile Virus Associated with a Neurological Sequela in Hamsters Identified by Motor Unit Number Estimation

Siddharthan

Wang

Motter

et al. 2009

J Virol

View full text Add to dashboard Cite

To investigate the hypothesis that neurological sequelae are associated with persistent West Nile virus (WNV) and neuropathology, we developed an electrophysiological motor unit number estimation (MUNE) assay to measure the health of motor neurons temporally in hamsters. The MUNE assay was successful in identifying chronic neuropathology in the spinal cords of infected hamsters. MUNE was suppressed at days 9 to 92 in hamsters injected subcutaneously with WNV, thereby establishing that a long-term neurological sequela does occur in the hamster model. MUNE suppression at day 10 correlated with the loss of neuronal function as indicated by reduced choline acetyltransferase staining (R 2 ‫؍‬ 0.91). Between days 10 and 26, some ␣-motor neurons had died, but further neuronal death was not detected beyond day 26. MUNE correlated with disease phenotype, because the lowest MUNE values were detected in paralyzed limbs. Persistent WNV RNA and foci of WNV envelope-positive cells were identified in the central nervous systems of all hamsters tested from 28 to 86 days. WNV-positive staining colocalized with the neuropathology, which suggested that persistent WNV or its products contributed to neuropathogenesis. These results established that persistent WNV product or its proteins cause dysfunction, that WNV is associated with chronic neuropathological lesions, and that this neurological sequela is effectively detected by MUNE. Inasmuch as WNV-infected humans can also experience a poliomyelitis-like disease where motor neurons are damaged, MUNE may also be a sensitive clinical or therapeutic marker for those patients.

show abstract

“…Le vieillissement spécifique des unités motrices [12] est, quant à lui, de mieux en mieux précisé, et s'intègre dans la discussion étiopathogénique du « syndrome post-polio » (réduction des motoneurones alpha, surtout de grande taille).…”

Section: Maintien Des Acquisunclassified

Place de la rééducation dans la prise en charge des patients porteurs de séquelles de poliomyélite

Hugeux

Petit

2009

Lett Med Phys Readapt

View full text Add to dashboard Cite

ARTICLE DE SYNTHÈSEPlace de la rééducation dans la prise en charge des patients porteurs de séquelles de poliomyélite Rehabilitation centre for the care of patients with post-polio sequelae P. Hugeux · F. Petit © Springer-Verlag 2009 Résumé Le médecin spécialiste de médecine physique et de réadaptation (MPR) a une vocation de coordonnateur et de médiateur dans la prise en charge des patients porteurs de séquelles de la maladie poliomyélitique. Ses connaissances neuro-orthopédiques et sa vision anticipatrice, multiforme et évolutive du handicap, en font le manager naturel qui accompagne, depuis le jeune enfant qui doit grandir jusqu'à la personne âgée qui devient très dépendante. Son savoir médicotechnique doit s'harmoniser avec le cheminement d'une existence où le patient est le coacteur de sa propre prise en charge, surtout lorsque surviennent les aléas du vieillissement naturel, les complications plus spécifiques de la maladie et les comorbidités intercurrentes. À chaque étape, la réflexion diagnostique et le projet thérapeutique doivent être discutés pour être réajustés, en collaboration avec les intervenants sanitaires, et éventuellement sociaux, qui participent à la démarche. Mots clés Poliomyélite · Médecine physique et de réadaptation (MPR) · Connaissances neuro-orthopédiques · Accompagnement · CoordinationAbstract Specialist rehabilitation physicians have a coordinator/mediator role to play in the care of patients with postpolio sequelae. Their neuro-orthopedic knowledge and forward-looking, multiform, and progressive vision of the handicap, makes them natural managers who monitor patients from young children who must grow up, to the elderly who become highly dependent. Their medicaltechnical knowledge must match the progression of an existence where the patient is a co-player in his own care, especially with the occurrence of the unforeseeable complications of the natural ageing process, the more specific complications of the disease, and intercurrent comorbidity. With each stage, diagnostic discussion and therapeutic plans must be debated in order to be readjusted, together with the medical and possibly social personnel who are involved in this approach.

show abstract

Motor Unit Number Estimation in Neuromuscular Disease

Cited by 25 publications

References 43 publications

Role of diffusion tensor imaging or magnetic resonance spectroscopy in the diagnosis and disability assessment of amyotrophic lateral sclerosis

Role of diffusion tensor imaging or magnetic resonance spectroscopy in the diagnosis and disability assessment of amyotrophic lateral sclerosis

Persistent West Nile Virus Associated with a Neurological Sequela in Hamsters Identified by Motor Unit Number Estimation

Place de la rééducation dans la prise en charge des patients porteurs de séquelles de poliomyélite

Contact Info

Product

Resources

About