Motor unit number estimation: A technology and literature review

Gooch, Clifton L.; Doherty, Timothy J.; Chan, K. Ming; Bromberg, Mark B.; Lewis, Richard A.; Stashuk, Daniel W.; Berger, Michael; Andary, Michael; Daube, Jasper R.

doi:10.1002/mus.24442

Cited by 123 publications

(143 citation statements)

References 126 publications

(517 reference statements)

Supporting

Mentioning

127

Contrasting

Unclassified

Order By: Relevance

“…The statistical method appears limited when individual large motor units are measured at a particular stimulus level rather than a Poisson distribution of motor units. The incremental, MPS and statistical methods have all shown reasonable test-retest reproducibility and appear sensitive to disease progression [3]. Currently, the incremental and MPS methods have been combined in the multipoint incremental method described in the next subsection.…”

Section: Established Mune Methods Based On Electrical Stimulationmentioning

confidence: 99%

“…Modifications such as decomposition spike-triggered averaging used a computerized algorithm to analyze multiple individual motor unit potentials. The aim of these methods was to calculate a mean motor unit size that can be divided into the total CMAP to determine a MUNE with reasonable reliability [3]. The need for specialized software and operator input has somewhat limited widespread applicability.…”

Section: Established Mune Methods Based On Needle or Surface Emg Methodsmentioning

confidence: 99%

“…Not all motor units are functional and so the number of motor units measured by functional tests may be less than the total number of motor units that could be measured by anatomic methods. The number of motor units appears to decline with age, and may vary greatly among people [1,[3][4][5].…”

Section: Anatomy Of Motor Unitsmentioning

confidence: 99%

“…In an attempt to develop a biomarker for the loss of motor units, the field of motor unit number estimates (MUNE) was developed in the 1970s [3]. Most of the electrophysiology methods have studied the thenar and hypothenar muscles supplied by the median or ulnar nerves, and, to a lesser extent, the extensor digitorum brevis or tibialis anterior muscles supplied by the peroneal nerve, although there are many small studies of other nerve, muscle combinations.…”

Section: Estimation Of the Number Of Motor Unitsmentioning

confidence: 99%

See 3 more Smart Citations

Assessment of Motor Units in Neuromuscular Disease

Henderson

McCombe

2017

Neurotherapeutics

View full text Add to dashboard Cite

show abstract

Section: Established Mune Methods Based On Electrical Stimulationmentioning

confidence: 99%

Section: Established Mune Methods Based On Needle or Surface Emg Methodsmentioning

confidence: 99%

Section: Anatomy Of Motor Unitsmentioning

confidence: 99%

Section: Estimation Of the Number Of Motor Unitsmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of Motor Units in Neuromuscular Disease

Henderson

McCombe

2017

Neurotherapeutics

View full text Add to dashboard Cite

show abstract

“…There is little indication in a traditional clinical neurophysiology practice, but several of the methods have been liberally applied in research over the years, mainly to observe changes over time. 26 Today, we have a strong clinical need in the form of reconstructive neurosurgery that demands a high degree of electromyographic quantification. A critical predictor of the outcome of transferring a nerve is the functioning motor axonal complement within the donor nerve.…”

Section: Clinical Assessmentmentioning

confidence: 99%

A neurophysiological approach to nerve transfer to restore upper limb function in cervical spinal cord injury

Mandeville¹,

Brown

Sheean³

2017

Neurosurgical Focus

View full text Add to dashboard Cite

A successful nerve transfer surgery can provide a wealth of benefits to a patient with cervical spinal cord injury. The process of surgical decision making ideally uses all pertinent information to produce the best functional outcome. Reliance on clinical examination and imaging studies alone can miss valuable information on the state of spinal cord health. In this regard, neurophysiological evaluation has the potential to effectively gauge the neurological status of even select pools of anterior horn cells and their axons to small nerve branches in question to determine the potential efficacy of their use in a transfer. If available preoperatively, knowledge gained from such an evaluation could significantly alter the reconstructive surgical plan and avoid poor results. The authors describe their institution’s approach to the assessment of patients with cervical spinal cord injury who are being considered for nerve transfer surgery in both the acute and chronic setting and broadly review the neurophysiological techniques used.

show abstract

Electromyography and neuromuscular disorders: Clinical-electrophysiologic correlations, 3rd Edition edited by David C.Preston and Barbara E.Shapiro, 664 pp., Elsevier Saunders, 2012, $199

Varma¹

2013

Muscle Nerve

View full text Add to dashboard Cite

In this edition, the authors have maintained the format of the prior editions. The book is divided into 8 sections. The first section is an overview of nerve conduction studies and includes anatomy and neurophysiology. Section 2 describes basic nerve conduction studies along with late responses, blink reflexes, and repetitive nerve stimulation studies. Section 3 reviews the technical factors and artifacts associated with nerve conduction studies. Section 4 describes the methods for performing a variety of nerve conduction studies with the aid of pictures and also explains key points to consider with various studies. The book changes course in section 5, and readers get a detailed overview of fundamentals of electromyography. I believe section 6 was most helpful, as it describes clinical-electrophysiological correlations of various common and also complicated clinical scenarios. Although I have read the book at least twice, I often find myself referring to the chapters in this section while doing complicated studies. The authors begin by going over the anatomy in each of these chapters and then describe the various clinical disorders. The case examples at the end of the chapters are actual cases from the authors' experience. For a reader, the interactive discussion of the cases is very helpful in interpreting one's own cases. The last 2 sections of the book review EMG in special settings and with special attention to the safety and risks of the procedure.Some welcome new features of this edition are its color images and cross-sectional views of muscles in the EMG section. Moreover, the book is now accessible online for quick reference. Readers can also listen to EMG sounds online instead of installing a CD, which was not always successful with the second edition. This is a very well-organized and clearly written book. I would recommend this book to all residents and clinical neurophysiology fellows as well as anyone who interprets nerve conduction studies and performs EMGs. The new textbook, Atlas of Nerve Conduction Studies and Electromyography, by Drs. A. Arturo Leis and Michael P. Shenk, begins with a preface that describes 2 goals for the text: (1) to serve as an anatomical guide for electromyographers when they perform electromyography (EMG) and nerve conduction studies (NCS); and (2) to give neurology professionals and other trainees and nonneurologists alike a guidebook for the anatomy of the peripheral nervous system and basic instruction for performing electrodiagnostic testing. Siddhartha Varma, MDThe first 2 chapters provide an overview of NCS and EMG. This overview, while brief, provides a framework for the chapters ahead and provides novice electromyographers and trainees with a good foundation for what follows.Chapter 3 offers an overview of the brachial plexus and areas of possible injury, common clinical features of brachial plexus injury, and strategies for performing EMG and NCS when a brachial plexopathy is in question. In this chapter there are multiple illustrations that help to simplify the c...

show abstract

Motor unit number estimation: A technology and literature review

Abstract: MUNE is an important research technique in human subjects, providing important data regarding motor unit populations and motor unit loss over time.

Cited by 123 publications

References 126 publications

Assessment of Motor Units in Neuromuscular Disease

Assessment of Motor Units in Neuromuscular Disease

A neurophysiological approach to nerve transfer to restore upper limb function in cervical spinal cord injury

Electromyography and neuromuscular disorders: Clinical-electrophysiologic correlations, 3rd Edition edited by David C.Preston and Barbara E.Shapiro, 664 pp., Elsevier Saunders, 2012, $199

Contact Info

Product

Resources

About