Motor threshold in transcranial magnetic stimulation: comparison of three estimation methods

Manual activity shapes structure and function in contralateral human motor hand area

“…Maximum stimulator output refers to the maximal intensity of stimulation that can be delivered with the MagPro X100 stimulator. The RMT was defined as the minimum stimulus intensity that evoked an MEP in the relaxed contralateral FDI muscle with a peak-to-peak amplitude of more than 50 μV in five out of 10 consecutive trials (Rossini et al, 1999;Tranulis et al, 2006).…”

Navigated transcranial magnetic stimulation and computed electric field strength reduce stimulator-dependent differences in the motor threshold

“…Although the basic definition of the MT is widely accepted, there is no consensus procedure on how it should be determined. Thus, several estimation algorithms have been proposed to aid in the process of MT determination, though none appears to offer clear superiority over the others (Tranulis et al, 2006). In the Mills-Nithi method, separate upper and lower MTs are determined and averaged, whereas most of the other methods rely on different maximum-likelihood-strategies, in which the intensity calculation of the next stimulus is based on the responses evoked by the preceding stimuli, such that the MT is obtained after a certain number of stimuli (Awiszus, 2003;Awiszus et al, 1999;Mills and Nithi, 1997;Mishory et al, 2004).…”

The effect of repetitive transcranial magnetic stimulation on monoamine outflow in the nucleus accumbens shell in freely moving rats

“…The individual motor threshold for each rat was determined visually on day 10 using the Rossini & Rothwell algorithm (Tranulis et al, 2006). Single pulses were applied with a circular coil (MCF-75 Circular, MagVenture A/S, DK), and the magnetic field strength was increased stepwise from 17% of total machine output, until a motor response was visible in 50% of applied pulses.…”