Motor System Interactions in the Beta Band Decrease during Loss of Consciousness

Swann, Nicole C.; Hemptinne, Coralie de; Maher, Ryan B.; Stapleton, Catherine A.; Meng, Lingzhong; Gelb, Adrian W.; Starr, Philip A.

doi:10.1162/jocn_a_00884

Cited by 12 publications

(8 citation statements)

References 62 publications

(109 reference statements)

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“…This increased α synchrony has been implicated to involve deep nuclear structures, such as the thalamus [51]. The observed dominance of pallidal α oscillations within pallidum (Both GPi and GPe) would be consistent with a theory of BG involvement in the thalamocortical α synchrony given that decreased power is generally related to reduced coupling across regions [25,26,51].…”

Section: Discussionsupporting

confidence: 65%

“…While there is some evidence to suggest that propofol decreases higher frequency (>20 Hz) power and increases lower frequency (<20 Hz) power in subcortical nuclei [25,26], there has been no prior assessment of spectral power changes specific to the GPi following propofol administration in PD patients. Further, concurrent change in GPe LFP, which may be crucial for the clinical context of lead targeting, is poorly characterized.…”

Section: Introductionmentioning

confidence: 99%

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Propofol Anesthesia Precludes LFP-Based Functional Mapping of Pallidum during DBS Implantation

Malekmohammadi

Sparks

AuYong

et al. 2018

Stereotact Funct Neurosurg

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Background/Aims: There are reports that microelectrode recording (MER) can be performed under certain anesthetized conditions for functional confirmation of the optimal deep brain stimulation (DBS) target. However, it is generally accepted that anesthesia affects MER. Due to a potential role of local field potentials (LFPs) in DBS functional mapping, we characterized the effect of propofol on globus pallidus interna (GPi) and externa (GPe) LFPs in Parkinson disease (PD) patients. Methods: We collected LFPs in 12 awake and anesthetized PD patients undergoing DBS implantation. Spectral power of β (13–35 Hz) and high-frequency oscillations (HFOs: 200–300 Hz) was compared across the pallidum. Results: Propofol suppressed GPi power by > 20 Hz while increasing power at lower frequencies. A similar power shift was observed in GPe; however, power in the high β range (20–35 Hz) increased with propofol. Before anesthesia both β and HFO activity were significantly greater at the GPi (χ² = 20.63 and χ² = 48.81, p < 0.0001). However, during anesthesia, we found no significant difference across the pallidum (χ² = 0.47, p = 0.79, and χ² = 4.11, p = 0.12). Conclusion: GPi and GPe are distinguishable using LFP spectral profiles in the awake condition. Propofol obliterates this spectral differentiation. Therefore, LFP spectra cannot be relied upon in the propofol-anesthetized state for functional mapping during DBS implantation.

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Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Propofol Anesthesia Precludes LFP-Based Functional Mapping of Pallidum during DBS Implantation

Malekmohammadi

Sparks

AuYong

et al. 2018

Stereotact Funct Neurosurg

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“…We employed ECoG during deep brain stimulation (DBS) implantation surgery in subjects with either Parkinson disease or essential tremor in order to delineate common patterns of change associated with propofol administration despite disease-specific cortical pathophysiology. We hypothesized that similar to the findings of propofol-induced diminished connectivity between subcortical and cortical brain activity 30 , propofol administration decreases sensorimotor cortical α and β connectivity in cortices, signifying a functional disconnection of them.…”

Section: Introductionmentioning

confidence: 81%

“…This pattern occurs similarly across diseases evaluated, suggesting these may be generalizable effects of propofol. Swann and colleagues who examined subcortical-motor cortex connectivity in a mixed group of patients with movement disorders 30 also observed propofol-induced reduction in subcortical-motor cortex coupling specific to β frequencies. Our current study further suggests that propofol administration results in the reduction of both inter-cortical and cortical-subcortical functional connectivity.…”

Section: Discussionmentioning

confidence: 99%

Propofol-induced Changes in α-β Sensorimotor Cortical Connectivity

et al. 2018

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Background Anesthetics are believed to alter functional connectivity across brain regions. However, network-level analyses of anesthesia, particularly in humans, are sparse. The authors hypothesized that propofol-induced loss of consciousness results in functional disconnection of human sensorimotor cortices underlying the loss of volitional motor responses. Methods The authors recorded local field potentials from sensorimotor cortices in patients with Parkinson disease (N = 12) and essential tremor (N = 7) undergoing deep brain stimulation surgery, before and after propofol-induced loss of consciousness. Local spectral power and interregional connectivity (coherence and imaginary coherence) were evaluated separately across conditions for the two populations. Results Propofol anesthesia caused power increases for frequencies between 2 and 100 Hz across the sensorimotor cortices and a shift of the dominant spectral peak in α and β frequencies toward lower frequencies (median ± SD peak frequency: 24.5 ± 2.6 Hz to 12.8 ± 2.3 Hz in Parkinson disease; 13.8 ± 2.1 Hz to 12.1 ± 1.0 Hz in essential tremor). Despite local increases in power, sensorimotor cortical coherence was suppressed with propofol in both cohorts, specifically in β frequencies (18 to 29 Hz) for Parkinson disease and α and β (10 to 48 Hz) in essential tremor. Conclusions The decrease in functional connectivity between sensory and motor cortices, despite an increase in local spectral power, suggests that propofol causes a functional disconnection of cortices with increases in autonomous activity within cortical regions. This pattern occurs across diseases evaluated, suggesting that these may be generalizable effects of propofol in patients with movement disorders and beyond. Sensorimotor network disruption may underlie anesthetic-induced loss of volitional control.

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“…While there are effects of propofol on STN neuronal activity (Raz et al, 2010) and STN LFP activity (Swann et al, 2016), the half-life for propofol elimination is short (Kanto and Gepts, 1989). Further, the majority of patients had LFP recorded on the second side during bilateral DBS implantation surgery (24/28 PD patients and 9/12 dystonia patients), which was >2 hours after cessation of propofol.…”

Section: Discussionmentioning

confidence: 99%

Subthalamic local field potentials in Parkinson's disease and isolated dystonia: An evaluation of potential biomarkers

Wang

Hemptinne

Miocinovic

et al. 2016

Neurobiology of Disease

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Local field potentials (LFP) recorded from the subthalamic nucleus in patients with Parkinson’s disease (PD) demonstrate prominent oscillations in the beta (13–30 Hz) frequency range, and reduction of beta band spectral power by levodopa and deep brain stimulation (DBS) is correlated with motor symptom improvement. Several features of beta activity have been theorized to be specific biomarkers of the parkinsonian state, though these have rarely been studied in non-parkinsonian conditions. To compare resting state LFP features in PD and isolated dystonia and evaluate disease-specific biomarkers, we recorded subthalamic LFPs from 28 akinetic-rigid PD and 12 isolated dystonia patients during awake DBS implantation. Spectral power and phase-amplitude coupling characteristics were analyzed. In 26/28 PD and 11/12 isolated dystonia patients, the LFP power spectrum had a peak in the beta frequency range, with similar amplitudes between groups. Resting state power did not differ between groups in the theta (5–8 Hz), alpha (8–12 Hz), beta (13–30 Hz), broadband gamma (50–200 Hz), or high frequency oscillation (HFO, 250–350 Hz) bands. Analysis of phase-amplitude coupling between low frequency phase and HFO amplitude revealed significant interactions in 19/28 PD and 6/12 dystonia recordings without significant differences in maximal coupling or preferred phase. Two features of subthalamic LFPs that have been proposed as specific parkinsonian biomarkers, beta power and coupling of beta phase to HFO amplitude, were also present in isolated dystonia, including focal dystonias. This casts doubt on the utility of these metrics as disease-specific diagnostic biomarkers.

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Motor System Interactions in the Beta Band Decrease during Loss of Consciousness

Cited by 12 publications

References 62 publications

Propofol Anesthesia Precludes LFP-Based Functional Mapping of Pallidum during DBS Implantation

Propofol Anesthesia Precludes LFP-Based Functional Mapping of Pallidum during DBS Implantation

Propofol-induced Changes in α-β Sensorimotor Cortical Connectivity

Subthalamic local field potentials in Parkinson's disease and isolated dystonia: An evaluation of potential biomarkers

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