Motor neurone disease and exposure to lead

Campbell, A. M. G.; Williams, Erin R.; Barltrop, D.

doi:10.1136/jnnp.33.6.877

Cited by 128 publications

(57 citation statements)

References 25 publications

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“…Since the 1970s, most studies have reported an association between exposure to metals, such as lead, mercury or others, and risk of ALS [10,11,12,13,14,15,16,17], although others have failed to find a statistically significantly increased risk of disease [18,19]. The relationship between exposure to pesticides, agricultural occupations and residing in a rural area and risk of ALS has been inconsistent as only about half of the epidemiologic studies, including two meta-analyses, have found an association [14,20,21,22,23,24,25].…”

Section: Introductionmentioning

confidence: 99%

Environmental and Occupational Risk Factors for Amyotrophic Lateral Sclerosis: A Case-Control Study

Malek

Barchowsky²,

Bowser

et al. 2013

Neurodegener Dis

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Background/Aims: Environmental and occupational exposures are implicated as risk factors for amyotrophic lateral sclerosis (ALS), the etiology of which is largely unknown, although no causal relationships have been established. Objective: The aim of the study was to evaluate the associations of personal risk factors and self-reported environmental and occupational exposures with risk of ALS. Methods: The cases involved ALS patients (n = 66) identified from major neurological centers in Pittsburgh and Philadelphia, Pa., USA, from 2008 to 2010. The age-, race- and sex-matched controls included outpatient hospital and population-based controls (n = 66). A detailed questionnaire obtaining data on occupation, vocational and avocational exposure as well as personal lifestyle factors was administered. Results: Occupational exposure to metals (odds ratio, OR = 3.65; 95% CI: 1.15, 11.60) and pesticides (OR = 6.50; 95% CI: 1.78, 23.77) was related to increased risk of ALS after controlling for smoking and education. No associations were found for occupational exposure to organic or aromatic solvents. Conclusion: Workers exposed to metals and pesticides may be at greater risk of ALS. Future research should involve more accurate exposure assessment through the use of job exposure matrices, confirmation of occupation and biomarkers.

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Section: Introductionmentioning

confidence: 99%

Environmental and Occupational Risk Factors for Amyotrophic Lateral Sclerosis: A Case-Control Study

Malek

Barchowsky²,

Bowser

et al. 2013

Neurodegener Dis

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“…Some disorders may mimic ALS, such as cervical myelopathy, paraneoplastic disorders, heavy metal intoxication, and some hereditary disorders (3). A few studies have reported the relationship between Motor Neuron Disease (MND) and lead poisoning (4)(5). Lead is a heavy metal that affects many organs, the most important of which is the central nervous system (6).…”

Section: Introductionmentioning

confidence: 99%

An Amyotrophic lateral Sclerosis like symptoms associated with lead toxicity

Alameddine

Karimi

2017

Iran J Health Sci

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Lead is a heavy metal that affects many organs such as nervous system, liver, and kidney. The most important affected organ is central nervous system. The present study reported a case similar to Amyotrophic lateral sclerosis due to lead exposure in an opium addicted person. The patient complaint was the weakness of upper and lower limbs in addition to the unsteadiness of gait. Nerve conduction studies showed normal sensory and motor action potential but needle electromyography showed fasciculation in distal and proximal muscles. The patient was encephalopathic and had psychiatric disorder. The blood lead level was also found to be higher than the normal upper limit. Hence, lead poisoning could occur in a patient addicted to opium with symptoms similar to Amyotrophic lateral sclerosis.

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“…The possibility of an association has been revived by Warren (15,19,20) by demonstrating that certain geographical areas with high environmental lead levels have a high incidence of multiple sclerosis. A number of studies (21)(22)(23) have reported an association of exposure to lead with motor neuron disease, but the etiological role of lead is not clear in these studies. Lead insult has also been associated with scrapie and swayback in sheep and kuru and amyotropic lateral sclerosis in humans (15).…”

Section: Effects Of Lead On the Nervous System Encephalopathymentioning

confidence: 99%

Toxicological Properties of Lead

Damstra¹

1977

Environmental Health Perspectives

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The pathological effects of lead on the renal, nervous, reproductive, endocrine, and immune systems have been reviewed. Emphasis is placed on reported subclinical effects due to chronic, low-level lead exposure. The crucial issue of whether subtle behavioral, inteUlectual, and developmental impairment occurs in young children, as a result of lead-induced CNS damage is discussed in deta;l. This issue remains unresolved. Further studies are needed in order to determine the long-term health effects of continuous, low-level lead exposure.

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Motor neurone disease and exposure to lead

Cited by 128 publications

References 25 publications

Environmental and Occupational Risk Factors for Amyotrophic Lateral Sclerosis: A Case-Control Study

Environmental and Occupational Risk Factors for Amyotrophic Lateral Sclerosis: A Case-Control Study

An Amyotrophic lateral Sclerosis like symptoms associated with lead toxicity

Toxicological Properties of Lead

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