Abstract:Amyotrophic lateral sclerosis (ALS) is a fatal disease primarily affecting motor neurons. In Europe and North America, about 5 % of ALS patients report a positive family history (familial ALS, fALS). The remaining is classified as sporadic ALS (sALS). A genetic basis for ALS has been demonstrated for both fALS and sALS and variants in > 40 genes have been associated with ALS. Following linkage analysis in families with Mendelian dominantly inherited fALS, mutations in the gene encoding the free radical scaveng… Show more
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