Motor neuron disease and malignancy

Younger, David S.

doi:10.1002/(sici)1097-4598(200005)23:5<658::aid-mus2>3.0.co;2-2

Cited by 17 publications

(3 citation statements)

References 11 publications

(4 reference statements)

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“…Other than women with primary lateral sclerosis, when should one worry about an associated malignancy in someone with MND? The presence of sensory symptoms, a pure lower motor neuron syndrome, and systemic complaints should raise the level of suspicion [33].…”

Section: Motor Neuropathy and Motor Neuronopathymentioning

confidence: 95%

Paraneoplastic syndromes of the peripheral nerves

Rudnicki

Dalmau

2005

Current Opinion in Neurology

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There is increasing recognition of an extensive variety of paraneoplastic disorders of the peripheral nerves. In many of these disorders onconeuronal antibodies are absent. Whole body fluorodeoxyglucose positron emission tomography scanning helps uncover the associated tumor, and recently proposed criteria may assist in the diagnosis. In many instances, prompt treatment of the tumor and immunotherapy result in symptom stabilization or neurologic improvement.

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Section: Motor Neuropathy and Motor Neuronopathymentioning

confidence: 95%

Paraneoplastic syndromes of the peripheral nerves

Rudnicki

Dalmau

2005

Current Opinion in Neurology

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“…Approximately 50% of all cancer patients will undergo radiation therapy at some point during the course of their disease, and radiation therapy is involved in approximately one quarter of all cancer cures [31]. As patients are living longer following cancer treatments, physicians are becoming more aware of late neuromuscular complications of therapy, especially radiation therapy.…”

Section: Plexopathymentioning

confidence: 99%

Electrodiagnosis in Cancer Rehabilitation

Custodio

2017

Physical Medicine and Rehabilitation Clinics of North America

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With numerous advancements in early detection and multi-modal therapy, cancer has become a chronic disease. As the number of cancer survivors continue to increase, physiatrists and other neuromuscular disease specialists are more likely to encounter individuals with residual impairments, disabilities, and/or handicaps resulting from cancer or related treatments. The cancer patient is especially prone to injury directed at the peripheral nervous system at multiple anatomic levels. Tumors can directly compress or infiltrate vital nervous system structures, or can cause severe neuromuscular disorders through a paraneoplastic process. Immunocompromised cancer patients are susceptible to indirect neurologic insult through secondary mechanisms such as infection or metabolic disorders. Cancer treatments themselves; including surgery, chemotherapy, radiation therapy, and hematopoietic stem cell transplant; can result in a wide variety of neuromuscular complications with a wide range of symptom and functional severity. Electrodiagnosis is an invaluable tool in the evaluation of neuromuscular disorders in this patient population.

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“…Isolierte, chronisch progrediente Motoneuronsyndrome sind in den allermeisten Fällen neurodegenerativer Genese [ 63 ] . Insbesondere sollte an eine paraneoplastische Genese gedacht werden bei (1) rasch progredientem Verlauf mit (2) einem isolierten zweiten Motoneuron Syndrom und (3) sensibler Beteiligung sowie (4) systemischen oder enzephalopathischen Symptomen [ 64 ] . Ursächlich sind dann vor allem Non-Hodgkin-Lymphome [ 65 ] .…”

Section: Seltenere Paraneoplastische Syndrome Des Zentralen Nervensysunclassified

Neues bei paraneoplastischen Syndromen in der Neurologie

2012

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Zusammenfassung In nur wenigen Jahren hat sich das Spektrum und damit das Wissen um paraneoplastische Syndrome in der Neurologie deutlich erweitert. Insbesondere hat die Beschreibung neuer fakultativ paraneoplastischer Subgruppen von Enzephalitiden mit gutem Ansprechen auf immunmodulatorische Therapien das klinische und wissenschaftliche Interesse verst?rkt. Das Erkennen dieser Subgruppen mittels neuartiger Autoantik?rper hat unmittelbare therapeutische Konsequenzen. Die fundierte Kenntnis paraneoplastischer Syndrome in der Neurologie ist daher ?u?erst wichtig f?r den Kliniker. Neue wissenschaftliche Erkenntnisse beleuchten interessante Aspekte der Pathophysiologie paraneoplastischer Prozesse, ihrer m?glichen Reversibilit?t und Initiierung. Neue Registerdaten helfen die Epidemiologie paraneoplastischer neurologischer Syndrome besser einzusch?tzen. Der zunehmende Einsatz von ?Biologika? in der Neurologie er?ffnet zuk?nftig neue Therapiechancen. Allerdings f?hrt die mittlerweile entstandene F?lle an neuen Syndromen und Autoantik?rpern auch vielfach zu Verwirrung und Unsicherheit. Diese ?bersichtsarbeit fasst daher neue und wichtige ?ltere Aspekte paraneoplastischer neurologischer Syndrome, ihrer Klassifikation, Pathophysiologie und Behandlung zusammen.

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Motor neuron disease and malignancy

Cited by 17 publications

References 11 publications

Paraneoplastic syndromes of the peripheral nerves

Paraneoplastic syndromes of the peripheral nerves

Electrodiagnosis in Cancer Rehabilitation

Neues bei paraneoplastischen Syndromen in der Neurologie

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