Motor learning of hands with auditory cue in patients with Parkinson’s disease

Chuma, Takayo; Reza, Mohammed Faruque; Ikoma, Katsunori; Mano, Yukio

doi:10.1007/s00702-005-0314-4

Cited by 35 publications

(26 citation statements)

References 28 publications

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“…In particular, the cerebellum is active when subjects perform externally guided (EG) movements (Jueptner et al 1996;van Donkelaar et al 2000), while the BG is active when subjects perform an action that is recalled by memory or internally guided (IG), e.g., as self-generated timing (Jahanshahi et al 1995;Jenkins et al 2000;Jueptner and Weiller 1998;Mushiake and Strick 1995). The latter type of motor learning is diminished in Parkinson's disease, but can be overcome with external visual or auditory cues (Chuma et al 2006;Jahanshahi et al 1995;Nowak et al 2006;Rascol et al 1997). Overall, EG tasks are primarily processed through the cerebello-TH-CX circuit in the normal condition, whereas IG tasks are primarily encoded in the BG-TH-CX circuit.…”

Section: Discussionmentioning

confidence: 99%

“…We examined the cerebellum because the cerebello-thalamo-cortical (cerebello-TH-CX) circuit is a significant motor system that runs in parallel to the BG-TH-CX (Lewis et al 2007). Furthermore, the cerebellum is a motor-related structure that can compensate for basal ganglia (BG) dysfunction in Parkinson's disease and provide motor function by increasing the reliance of external cues by Parkinson's disease patients (Azulay et al 1999;Chuma et al 2006;Freeman et al 1993;Georgiou et al 1993;Jahanshahi et al 1995;Nowak et al 2006;Rascol et al 1997;Sen et al 2010;Yu et al 2007). In addition, imaging studies (Asanuma et al 2006;Grafton et al 2006;Helmich et al 2011;Hilker et al 2003;Hilker et al 2004;Mure et al 2012;Sestini et al 2005;Sidtis et al 2012;Wang et al 2010) and c-fos staining in the dentate nucleus of the cerebellum (MoersHornikx et al 2011) show that STN-DBS alters cerebellar activity in Parkinson's disease.…”

Section: Introductionmentioning

confidence: 99%

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Stimulation of the subthalamic nucleus engages the cerebellum for motor function in parkinsonian rats

et al. 2014

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Deep brain stimulation (DBS) is effective in managing motor symptoms of Parkinson's disease in well-selected individuals. Recently, research has shown that DBS in the basal ganglia (BG) can alter neural circuits beyond the traditional basal ganglia-thalamus-cortical (BG-TH-CX) loop. For instance, functional imaging showed alterations in cerebellar activity with DBS in the subthalamic nucleus (STN). However, these imaging studies revealed very little about how cell-specific cerebellar activity responds to STN stimulation or if these changes contribute to its efficacy. In this study, we assess whether STN-DBS provides efficacy in managing motor symptoms in Parkinson's disease by recruiting cerebellar activity. We do this by applying STN-DBS in hemiparkinsonian rats and simultaneously recording neuronal activity from the STN, brainstem and cerebellum. We found that STN neurons decreased spiking activity by 55% during DBS (P = 0.038), which coincided with a decrease in most pedunculopontine tegmental nucleus and Purkinje neurons by 29% (P < 0.001) and 28% (P = 0.003), respectively. In contrast, spike activity in the deep cerebellar nuclei increased 45% during DBS (P < 0.001), which was likely from reduced afferent activity of Purkinje cells. Then, we applied STN-DBS at sub-therapeutic current along with stimulation of the deep cerebellar nuclei and found similar improvement in forelimb akinesia as with therapeutic STN-DBS alone. This suggests that STN-DBS can engage cerebellar activity to improve parkinsonian motor symptoms. Our study is the first to describe how STN-DBS in Parkinson's disease alters cerebellar activity using electrophysiology in vivo and reveal a potential for stimulating the cerebellum to potentiate deep brain stimulation of the subthalamic nucleus.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stimulation of the subthalamic nucleus engages the cerebellum for motor function in parkinsonian rats

et al. 2014

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“…Studies suggest that cueing may stimulate alternative cortical pathways (eg, visual motor pathways) 32 to bypass the basal ganglia, whereas other studies suggest that cueing synchronizes the simultaneous timing of interlimb coordination in the cerebellum needed for normal gait. 33,34 Further studies are needed to investigate the neurophysiological mechanisms underpinning the effectiveness of rhythmic cueing in patients with PD.…”

Section: Discussionmentioning

confidence: 99%

Does Cueing Training Improve Physical Activity in Patients With Parkinson’s Disease?

Lim

Wegen

Jones

et al. 2010

Neurorehabil Neural Repair

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Background. Patients with Parkinson's disease (PD) are encouraged to stay active to maintain their mobility. Ambulatory activity monitoring (AM) provides an objective way to determine type and amount of gait-related daily activities. Objective. To investigate the effects of a home cueing training program on functional walking activity in PD. Methods. In a single-blind, randomized crossover trial, PD patients allocated to early intervention received cueing training for 3 weeks, whereas the late intervention group received training in the following 3 weeks. Training was applied at home, using a prototype cueing device. AM was applied at baseline, 3, 6, and 12 weeks in the patient's home, to record body movements. Postures and motions were classified as percentage of total time spent on (a) static activity, further specified as % sitting and % standing, and (b) % dynamic activity, further specified as % walking, % walking periods exceeding 5 seconds (W>5s) and 10 seconds (W> 1 0s). Random coefficient analysis was applied. Results. A total of 153 patients participated in this trial. Significant improvements were found for dynamic activity (b = 4.46; P < .01), static activity (b = -3.34; P < .01), walking (b = 4.23; P < .01), W>5s (b = 2.63; P < .05), and W> 1 0s (b = 2.90; P < .01). All intervention effects declined significantly at 6 weeks follow-up. Conclusion. Cueing training in PD patients' own home significantly improves the amount of walking as recorded by AM. Treatment effects reduced after the intervention period, pointing to the need for permanent cueing devices and follow-up cueing training.

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“…These data suggest that the route from sensory input to cerebellum to premotor cortex could compensate for the decreased function of the route via the basal ganglion to the premotor cortex [8].Once change occurred in the motor cortex,the change persisted even after interruption of the training. These phenomena suggest that motor memory can be stored in the motor cortex [9].…”

Section: Exercise and Educationmentioning

confidence: 81%

Rehabilitation for patients with Parkinson's disease

Chuma

2007

J Neurol

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Motor learning of hands with auditory cue in patients with Parkinson’s disease

Cited by 35 publications

References 28 publications

Stimulation of the subthalamic nucleus engages the cerebellum for motor function in parkinsonian rats

Stimulation of the subthalamic nucleus engages the cerebellum for motor function in parkinsonian rats

Does Cueing Training Improve Physical Activity in Patients With Parkinson’s Disease?

Rehabilitation for patients with Parkinson's disease

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