Motor inhibition and response expectancy: A Laplacian ERP study

Meckler, Cédric; Allain, Sonia; Carbonnell, Laurence; Hasbroucq, Thierry; Burle, Borı́s; Vidal, Franck

doi:10.1016/j.biopsycho.2010.08.011

Cited by 31 publications

(38 citation statements)

References 35 publications

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“…Signals are time-locked to the onset of the stimulus and baseline-corrected −100 to 0 msec before the stimulus-locking event. Anticorrelated ramping activities start to develop around 180 msec, betraying the contralateral activation (negativity)/ipsilateral inhibition (positivity) pattern highlighted by previous work (e.g., Vidal et al, 2003Vidal et al, , 2011Meckler et al, 2010). Our first linking proposition conjectures that this pattern is the neural signature of the controlled decision process hypothesized by drift diffusion models.…”

Section: Behaviorsupporting

confidence: 49%

“…Contrary to the LRP, CSD methods allow isolation of the electrical activity from each M1. In two-choice tasks, they have revealed a developing negativity over M1 contralateral to the response along with a developing positivity over M1 ispilateral (Burle, Van den Wildenberg, Spieser, & Ridderinkhof, in press;Vidal et al, 2011;Meckler et al, 2010;Vidal, Grapperon, Bonnet, & Hasbroucq, 2003). These components peak around the onset of EMG activity responsible for the response (Figure 2A).…”

Section: Linking Propositionsmentioning

confidence: 98%

“…These components peak around the onset of EMG activity responsible for the response (Figure 2A). Converging results from corticograms, intracortical data and stimulation studies indicate that the contralateral negativity corresponds to an activation of the motor command whereas the ipsilateral positivity corresponds to an inhibition of the nonrequired response (reviewed by Burle, Vidal, Tandonnet, & Hasbroucq, 2004; see also Meckler et al, 2010). Capitalizing upon these findings, the first linking proposition conjectures that the activation/inhibition EEG pattern over M1s is the neural signature of the controlled decision process hypothesized by drift diffusion models.…”

Section: Linking Propositionsmentioning

confidence: 98%

See 2 more Smart Citations

Linking Theoretical Decision-making Mechanisms in the Simon Task with Electrophysiological Data: A Model-based Neuroscience Study in Humans

Servant

White

Montagnini

et al. 2016

Journal of Cognitive Neuroscience

103

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A current challenge for decision-making research is in extending models of simple decisions to more complex and ecological choice situations. Conflict tasks (e.g., Simon, Stroop, Eriksen flanker) have been the focus of much interest, because they provide a decision-making context representative of everyday life experiences. Modeling efforts have led to an elaborated drift diffusion model for conflict tasks (DMC), which implements a superimposition of automatic and controlled decision activations. The DMC has proven to capture the diversity of behavioral conflict effects across various task contexts. This study combined DMC predictions with EEG and EMG measurements to test a set of linking propositions that specify the relationship between theoretical decision-making mechanisms involved in the Simon task and brain activity. Our results are consistent with a representation of the superimposed decision variable in the primary motor cortices. The decision variable was also observed in the EMG activity of response agonist muscles. These findings provide new insight into the neurophysiology of human decision-making. In return, they provide support for the DMC model framework.

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Section: Behaviorsupporting

confidence: 49%

Section: Linking Propositionsmentioning

confidence: 98%

Section: Linking Propositionsmentioning

confidence: 98%

See 1 more Smart Citation

Linking Theoretical Decision-making Mechanisms in the Simon Task with Electrophysiological Data: A Model-based Neuroscience Study in Humans

Servant

White

Montagnini

et al. 2016

Journal of Cognitive Neuroscience

103

View full text Add to dashboard Cite

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“…This negative wave is thought to reflect activation of the motor cortex that controls the goal-directed correct response (e.g., C3 for responses by the right hand). Concurrently, a positive-going wave develops at electrodes contralateral to the non-selected response hand (i.e., ipsilateral to the responding hand; e.g., C4 for responses by the right hand) that is thought to reflect the simultaneous inhibition of activity in the motor cortex that controls production of the incorrect response (for reviews see Burle, 2004; Carbonell et al, 2004; Meckler et al, 2010; Meynier, Burle, Possamai, Vidal, & Hasbroucq, 2009; van de Laar et al, 2012; Vidal et al, 2003). Given the deficits in inhibitory action control among PD patients, we reasoned that the response-locked surface Laplacian technique could provide new insights about the degree of suppression of conflicting motor responses at M1, especially in situations involving speed stress.…”

Section: Introductionmentioning

confidence: 99%

Speed pressure in conflict situations impedes inhibitory action control in Parkinson's disease

Wouwe

Wildenberg

Claassen

et al. 2014

Biological Psychology

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Parkinson’s disease (PD) is a neurodegenerative basal ganglia disease that disrupts cognitive control processes involved in response selection. The current study investigated the effects of PD on the ability to resolve conflicts during response selection when performance emphasized response speed versus response accuracy. Twenty-one (21) PD patients and 21 healthy controls (HC) completed a Simon conflict task, and a subset of 10 participants from each group provided simultaneous movement-related potential (MRP) data to track patterns of motor cortex activation and inhibition associated with the successful resolution of conflicting response tendencies. Both groups adjusted performance strategically to emphasize response speed or accuracy (i.e., speed-accuracy effect). For HC, interference from a conflicting response was reduced when response accuracy rather than speed was prioritized. For PD patients, however, there was a reduction in interference, but it was not statistically significant. The conceptual framework of the Dual-Process Activation-Suppression (DPAS) model revealed that the groups experienced similar susceptibility to making fast impulsive errors in conflict trials irrespective of speed-accuracy instructions, but PD patients were less proficient and delayed compared to HC at suppressing the interference from these incorrect response tendencies, especially under speed pressure. Analysis of MRPs on response conflict trials showed attenuated inhibition of the motor cortex controlling the conflicting impulsive response tendency in PD patients compared to HC. These results further confirm the detrimental effects of PD inhibitory control mechanisms and their exacerbation when patients perform under speed pressure. The results also suggest that a downstream effect of inhibitory dysfunction in PD is diminished inhibition of motor cortex controlling conflicting response tendencies.

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“…In order to give a more fine-grained characterization of the neural sources of these potentials and the associated oscillatory brain activity, several studies have used the Laplacian transformed activity of the EEG obtaining the current source density (CSD) waveforms (Nunez, 2002; Carbonnell et al, 2004; Kayser et al, 2010; Meckler et al, 2010; Tenke and Kayser, 2012). This method allows evaluating the topographical distribution of the brain activity in terms of current sources and sinks through the scalp (Kayser and Tenke, 2006).…”

Section: Introductionmentioning

confidence: 99%

Linking motor-related brain potentials and velocity profiles in multi-joint arm reaching movements

Amengual

Marco-Pallarés

Grau

et al. 2014

Front. Hum. Neurosci.

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The study of the movement related brain potentials (MRPBs) needs accurate technical approaches to disentangle the specific patterns of bran activity during the preparation and execution of movements. During the last forty years, synchronizing the electromyographic activation (EMG) of the muscle with electrophysiological recordings (EEG) has been commonly ussed for these purposes. However, new clinical approaches in the study of motor diseases and rehabilitation suggest the demand of new paradigms that might go further into the study of the brain activity associated with the kinematics of movements. As a response to this call, we have used a 3-D hand-tracking system with the aim to record continuously the position of an ultrasonic sender attached to the hand during the performance of multi-joint self-paced movements. We synchronized time-series of position and velocity of the sender with the EEG recordings, obtaining specific patterns of brain activity as a function of the fluctuations of the kinematics during natural movement performance. Additionally, the distribution of the brain activity during the preparation and execution phases of movements was similar that reported previously using the EMG, suggesting the validity of our technique. We claim that this paradigm could be usable in patients because of its simplicity and the potential knowledge that can be extracted from clinical protocols.

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Motor inhibition and response expectancy: A Laplacian ERP study

Cited by 31 publications

References 35 publications

Linking Theoretical Decision-making Mechanisms in the Simon Task with Electrophysiological Data: A Model-based Neuroscience Study in Humans

Linking Theoretical Decision-making Mechanisms in the Simon Task with Electrophysiological Data: A Model-based Neuroscience Study in Humans

Speed pressure in conflict situations impedes inhibitory action control in Parkinson's disease

Linking motor-related brain potentials and velocity profiles in multi-joint arm reaching movements

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