Motor excitability during movement imagination and movement observation in psychogenic lower limb paresis

Liepert, Joachim; Hassa, Thomas; Tüscher, Oliver; Schmidt, Roger

doi:10.1016/j.jpsychores.2010.06.004

Cited by 39 publications

(33 citation statements)

References 38 publications

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“…A similar pattern of suppression of CM excitability has been shown during MI of foot movement in patients suffering from motor CD weakness of their lower limbs (Liepert, et al, 2011). These findings (Liepert, et al, 2008(Liepert, et al, , 2009(Liepert, et al, , 2011 (Blakemore, et al, 2015).…”

Section: Motor Imagery and Motor Conversion Disordersupporting

confidence: 77%

“…These findings (Liepert, et al, 2008(Liepert, et al, , 2009(Liepert, et al, , 2011 (Blakemore, et al, 2015). Patients showed longer premotor (the central component of reaction time) and motor times (the peripheral component of reaction time) in both their symptomatic and asymptomatic limbs compared to healthy controls.…”

Section: Motor Imagery and Motor Conversion Disordermentioning

confidence: 82%

“…The findings of Liepert, et al (2008Liepert, et al ( , 2009Liepert, et al ( , 2011 and Blakemore, et al (2015) indicate that imagery related movement suppression may be involved in motor CD. Normally a presumed inhibitory mechanism prevents overt movement during kinaesthetic MI.…”

Section: Motor Imagery and Motor Conversion Disordermentioning

confidence: 88%

“…Direct evidence of impaired MI abilities in people suffering from functional movement disorders has been found (Liepert, et al, 2008(Liepert, et al, , 2009(Liepert, et al, , 2011 As well as the suppression of CM excitability during MI of the affected limb, CM excitability during MI of the unaffected limb was reduced relative to controls in a larger sample of patients suffering from upper limb CD (Liepert, et al, 2009). Liepert, et al (2009 used TMS to assess CM excitability during imagery of tonic index finger adduction in eight patients with upper limb motor CD (five patients had weakness, three a spastic dystonia), and a healthy control group.…”

Section: Motor Imagery and Motor Conversion Disordermentioning

confidence: 99%

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Can motor imagery and hypnotic susceptibility explain Conversion Disorder with motor symptoms?

et al. 2016

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Section: Motor Imagery and Motor Conversion Disordersupporting

confidence: 77%

Section: Motor Imagery and Motor Conversion Disordermentioning

confidence: 82%

Section: Motor Imagery and Motor Conversion Disordermentioning

confidence: 88%

Section: Motor Imagery and Motor Conversion Disordermentioning

confidence: 99%

See 2 more Smart Citations

Can motor imagery and hypnotic susceptibility explain Conversion Disorder with motor symptoms?

et al. 2016

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“…30 Morita et al 31 showed that in response to the signal cue to move, the MEP had greater variance in patients with functional paralysis (N=10) compared with patients with amyotrophic lateral sclerosis and healthy controls. Liepert et al 32 showed that in response to motor imagery, patients with unilateral functional paralysis (N=5) or fixed dystonia (N=3) had a decrease in MEP of the affected hand by 37%, compared with rest with an increase in MEP by 63% of the unaffected side These findings were specific to MEPs because motor threshold, short intracortical inhibition, and intracortical facilitation were shown to be unremarkable among individuals with functional paralysis. 33,34 In healthy individuals, motor imagery commonly increases MEPs to a level comparable to that observed during executed movements.…”

mentioning

confidence: 99%

Functional Neuroanatomy and Neurophysiology of Functional Neurological Disorders (Conversion Disorder)

Voon¹,

Cavanna²,

Coburn³

et al. 2016

JNP

131

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Much is known regarding the physical characteristics, comorbid symptoms, psychological makeup, and neuropsychological performance of patients with functional neurological disorders (FNDs)/conversion disorders. Gross neurostructural deficits do not account for the patients' deficits or symptoms. This review describes the literature focusing on potential neurobiological (i.e. functional neuroanatomic/neurophysiological) findings among individuals with FND, examining neuroimaging and neurophysiological studies of patients with the various forms of motor and sensory FND. In summary, neural networks and neurophysiologic mechanisms may mediate "functional" symptoms, reflecting neurobiological and intrapsychic processes. J Neuropsychiatry Clin Neurosci 2016; 28:168-190; doi: 10.1176/appi.neuropsych.14090217 Functional neurological disorders (FNDs; or psychogenic neurological symptoms), also known as conversion disorder, are a classic neuropsychiatric disorder, existing in the border between neurology and psychiatry. Unexplained neurological symptoms are common, occurring in up to one-third of patients in neurological outpatient clinics.1 Relative to disorders such as Parkinson's disease, FND is associated with similar levels of disability and physical quality of life with poorer mental health quality of life. 2 The prognosis is poor, with a recent reviewshowing that up to 40% of patients with FND report similar or worse outcomes at 7-year follow-up. 3 Given the frequency, consequences, prognosis, and burden, FND has been called a "crisis for neurology." 4 Despite this, FND is poorly understood. In the last decade, an increasing number of studies have focused on underlying neurobiological mechanisms. FND is defined in DSM-5 as the presence of one or more symptoms of altered voluntary or sensory function, with clinical findings providing evidence of incompatibility between the symptom and recognized neurological or medical conditions.5 The DSM-5 diagnosis differs from that of the DSM-IV diagnosis of conversion disorder by adding the criterion of incorporating physical diagnostic features and by relegating to the accompanying text the criteria requiring (a) an association with psychological stressors and (b) the exclusion of malingering or factitious disorder to make the diagnosis. DSM-5 FND diagnosis criteria now allow for potential greater interrater reliability, making them appropriate for research studies and greater compatibility with specialtyspecific diagnoses including psychogenic movement disorder (PMD) and psychogenic nonepileptic seizures (PNES). 6The putative biopsychosocial mechanisms underlying FND are complex and have been extensively reviewed.7 Our review focuses on the physiological mechanisms that may underlie FND and does not specifically focus on the extensive literature on the antecedents of early childhood experiences and temperament (Figure 1). At the outset, regarding the proposed model, we acknowledge that predisposing factors for functional neurological symptoms are not limited to genetics, te...

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Free Will, Emotions and Agency: Pathophysiology of Functional Movement Disorder

Hallett

2022

Current Clinical Neurology

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Motor excitability during movement imagination and movement observation in psychogenic lower limb paresis

Cited by 39 publications

References 38 publications

Can motor imagery and hypnotic susceptibility explain Conversion Disorder with motor symptoms?

Can motor imagery and hypnotic susceptibility explain Conversion Disorder with motor symptoms?

Functional Neuroanatomy and Neurophysiology of Functional Neurological Disorders (Conversion Disorder)

Free Will, Emotions and Agency: Pathophysiology of Functional Movement Disorder

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