Motor Dysfunction Correlates with Frontal White Matter Ischemic Changes in Patients with Leukoaraiosis

Viana-Baptista, Miguel; Bugalho, Paulo; Jordão, Constança; Ribeiro, Olga; Esperança-Pina, J. A.; Ferro, José M.

doi:10.4061/2011/950341

Cited by 14 publications

(12 citation statements)

References 26 publications

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“…WML burden has been associated with decreased capacity for gross motor function such as gait, as well as visuo-psychomotor function, in people older than 65 years. 6,[26][27][28] However, this is the first study to suggest that in a higher-risk population, the associations exist at much younger ages.…”

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confidence: 69%

“…Because early but mild impairment in performance occurs with increasing WML burden, it would be important to determine the extent to which progression of WMLs can be delayed by traditional approaches to vascular disease prophylaxis. 6,28,31 AUTHOR CONTRIBUTIONS Paul A. Nyquist designed and conceptualized the study, aided in the analysis and interpretation of the data, wrote and drafted the final manuscript, and is responsible for its final content. Lisa R. Yanek aided in the analysis and interpretation of the data and helped draft the final manuscript.…”

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confidence: 99%

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Effect of white matter lesions on manual dexterity in healthy middle-aged persons

et al. 2015

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Objectives: We hypothesized that integrated motor-visual functions measured by manipulative manual dexterity are affected by white matter lesion (WML) burden as measured on cranial MRI across relevant brain regions in subjects at risk of preclinical occult vascular disease.Methods: A real-time cross-sectional study of healthy subjects aged 29 to 74 years with a family history of early-onset coronary artery disease (n 5 714; mean age, 51 6 11 years; mean education, 14 6 3 years; 42% male; 38% black) were identified from probands with coronary artery disease diagnosed before age 60 years. WMLs on 3-tesla brain MRI and Grooved Pegboard scores were measured.Results: WMLs were observed at all ages. Mean pegboard scores were 108 6 18, similar to normal populations. In unadjusted analysis, WMLs and pegboard scores were significantly correlated by region (total WMLs, r 5 0. . In multivariate analysis predicting (log) pegboard score adjusted for age, sex, race, education, regional or total volumes, and familial nonindependence, total WML volume (p 5 5.79E 2 05) and regional WML volumes (p , 0.01) retained statistical significance in all but the youngest age quartile (29-43 years).Conclusions: Greater WML volumes in different brain regions are associated with higher pegboard scores (worse performance) independent of age, sex, race, education, and total or regional volumes. This suggests that small vessel cerebrovascular disease may be present in healthy individuals in a preclinical state with measurable impact on complex integrative functions in individuals with excess risk of clinical vascular disease. Neurology ® 2015;84:1920-1926 GLOSSARY CAD 5 coronary artery disease; FLAIR 5 fluid-attenuated inversion recovery; MMSE 5 Mini-Mental State Examination; MPRAGE 5 magnetization-prepared rapid-gradient echo; TOADS 5 topology-preserving anatomy-driven segmentation; WML 5 white matter lesion.White matter lesions (WMLs) appearing as hyperintense regions on fluid-attenuated inversion recovery (FLAIR) and T2 MRIs are thought to be caused by small vessel cerebrovascular disease.1 WML volume and number are associated with age and are most notable in older age groups.1,2 Overall, WML burden is an independent predictor of clinical dementia and of decrements in motor function, including gait, psychomotor speed, and motor apraxia. [3][4][5][6] We have published data that show a high prevalence of occult coronary artery disease (CAD) and cerebral small vessel lesions in younger and middle-aged people from families with a history of early-onset CAD.7-9 High-risk individuals may also be at increased risk of functional consequences of occult small vessel cerebrovascular disease. 9 To date, most studies of WMLs have addressed older populations and persons with cognitive functional decline or clinical dementia. 2The Northern Manhattan Study, which was conducted in a healthy community population, found that patients with a WML volumetric threshold at the 75th percentile performed

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Effect of white matter lesions on manual dexterity in healthy middle-aged persons

et al. 2015

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“…Most notably, an increase in size and intensity of white matter hyperintensities indicates the presence of demyelination and/or dilated perivascular spaces. White matter hyperintensity has been linked to mobility limitation, marked by slow walking speed,(Moscufo, Wolfson, Meier, Liguori, Hildenbrand, Wakefield, Schmidt, Pearlson, and Guttmann 2012;Rosano, Sigurdsson, Siggeirsdottir, Phillips, Garcia, Jonsson, Eiriksdottir, Newman, Harris, van Buchem, Gudnason, and Launer 2010;Viana-Baptista, Bugalho, Jordao, Ribeiro, Esperanca-Pina, and Ferro 2011;Wakefield, Moscufo, Guttmann, Kuchel, Kaplan, Pearlson, and Wolfson 2010;Willey, Scarmeas, Provenzano, Luchsinger, Mayeux, and Brickman 2013) and may attenuate the potential for rehabilitation induced gains in walking speed. (Nadkarni, Studenski, Perera, Rosano, Aizenstein, Brach, and Van Swearingen 2013) Altered connectivity in neuronal networks, as measured by transcranial magnetic stimulation, has also been associated with improvements in physical function in older adults.…”

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confidence: 99%

Successful aging: Advancing the science of physical independence in older adults

Anton

Woods

Ashizawa

et al. 2015

Ageing Research Reviews

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The concept of ‘Successful Aging’ has long intrigued the scientific community. Despite this long-standing interest, a consensus definition has proven to be a difficult task, due to the inherent challenge involved in defining such a complex, multi-dimensional phenomenon. The lack of a clear set of defining characteristics for the construct of successful aging has made comparison of findings across studies difficult and has limited advances in aging research. The domain in which consensus on markers of successful aging is furthest developed is the domain of physical functioning. For example, walking speed appears to be an excellent surrogate marker of overall health and predicts the maintenance of physical independence, a cornerstone of successful aging. The purpose of the present article is to provide an overview and discussion of specific health conditions, behavioral factors, and biological mechanisms that mark declining mobility and physical function and promising interventions to counter these effects. With life expectancy continuing to increase in the United States and developed countries throughout the world, there is an increasing public health focus on the maintenance of physical independence among all older adults.

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“…Bilateral, patchy, or diffuse areas of hypodensity on computed tomography or hyperintensities on T2-weighted magnetic resonance imaging (MRI) scans are the typical imaging findings [4]. Clinical fea-DOI: 10.1159/000505157 tures such as cognitive dysfunction, motor dysfunction, depression, and urinary problems have been associated with LA [5,6]. Despite the numerous studies on LA and CSVD, the pathological mechanism of LA remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Potential Mechanism of Venous System for Leukoaraiosis: From post-mortem to in vivo Research

et al. 2019

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Background: Leukoaraiosis (LA), widely accepted as a feature of cerebral small vessel disease, significantly increases the incidence of stroke, dementia, and death. Cerebral small artery disease has been considered as one of the main causes of LA. However, since the term "venous collagenosis" (VC) was proposed in an atrophy research in 1995, there have been pathological and neuroimaging studies proving the association between the venous system and LA in aging, Alzheimer's disease (AD), and Parkinson's disease. Summary: Autopsy studies confirmed that thickening of the lumen wall in venules, which results from the deposition of collagen I and III, leading to vessel stenosis or occlusion, is closely associated with LA. Susceptibility-weighted imaging research revealed a controversial association of deep medullary veins and LA in vivo, regarding which there are no standard criteria currently. Nevertheless, retinal venous changes had been reported to increase the risk of LA development, providing a novel way for in vivo evaluation. As for the internal jugular vein, jugular venous reflux could double the LA score in aging and modulate circulation of cerebral spinal fluids. Key Messages: Disruption of the venous system was notably associated with LA in aging, AD, and Parkinson's disease postmortem and in in vivo models. The venous pathological changes may induce cerebral hypoperfusion, drainage system disruption, and vasogenic oedema in the veins around the periventricular white matter. The clarification of VC in LA may provide an early prevention and early treatment strategy for LA patients.

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Motor Dysfunction Correlates with Frontal White Matter Ischemic Changes in Patients with Leukoaraiosis

Cited by 14 publications

References 26 publications

Effect of white matter lesions on manual dexterity in healthy middle-aged persons

Effect of white matter lesions on manual dexterity in healthy middle-aged persons

Successful aging: Advancing the science of physical independence in older adults

Potential Mechanism of Venous System for Leukoaraiosis: From post-mortem to in vivo Research

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