Motor behaviors in the sheep evoked by electrical stimulation of the subthalamic nucleus

Lentz, Linnea; Zhao, Yan; Kelly, M. J.; Schindeldecker, W.; Goetz, Steven; Nelson, Dwight E.; Raike, Robert S.

doi:10.1016/j.expneurol.2015.07.022

Cited by 6 publications

(3 citation statements)

References 95 publications

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“…This is based on the early clinical experience just after DBS was first approved, where multiple lead fractures were observed when connectors were placed in the neck (Schwalb et al, 2001 ; Hariz, 2002 ). Moreover, a recent study in this same ovine animal model also reported a high incidence of DBS lead fractures found to be related to connector location (Lentz et al, 2015 ).…”

Section: Discussionmentioning

confidence: 75%

Long Term Performance of a Bi-Directional Neural Interface for Deep Brain Stimulation and Recording

Stanslaski

Case

Giftakis

et al. 2022

Front. Hum. Neurosci.

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Background: In prior reports, we described the design and initial performance of a fully implantable, bi-directional neural interface system for use in deep brain and other neurostimulation applications. Here we provide an update on the chronic, long-term neural sensing performance of the system using traditional 4-contact leads and extend those results to include directional 8-contact leads.Methods: Seven ovine subjects were implanted with deep brain stimulation (DBS) leads at different nodes within the Circuit of Papez: four with unilateral leads in the anterior nucleus of the thalamus and hippocampus; two with bilateral fornix leads, and one with bilateral hippocampal leads. The leads were connected to either an Activa PC+S® (Medtronic) or Percept PC°ledR (Medtronic) deep brain stimulation and recording device. Spontaneous local field potentials (LFPs), evoked potentials (EPs), LFP response to stimulation, and electrode impedances were monitored chronically for periods of up to five years in these subjects.Results: The morphology, amplitude, and latencies of chronic hippocampal EPs evoked by thalamic stimulation remained stable over the duration of the study. Similarly, LFPs showed consistent spectral peaks with expected variation in absolute magnitude dependent upon behavioral state and other factors, but no systematic degradation of signal quality over time. Electrode impedances remained within expected ranges with little variation following an initial stabilization period. Coupled neural activity between the two nodes within the Papez circuit could be observed in synchronized recordings up to 5 years post-implant. The magnitude of passive LFP power recorded from directional electrode segments was indicative of the contacts that produced the greatest stimulation-induced changes in LFP power within the Papez network.Conclusion: The implanted device performed as designed, providing the ability to chronically stimulate and record neural activity within this network for up to 5 years of follow-up.

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Section: Discussionmentioning

confidence: 75%

Long Term Performance of a Bi-Directional Neural Interface for Deep Brain Stimulation and Recording

Stanslaski

Case

Giftakis

et al. 2022

Front. Hum. Neurosci.

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“…To our knowledge, there has not been a single peer-reviewed published study using 6-OHDA to create a sheep model of PD. Lentz and colleagues (2015) developed a novel sheep model of STN-DBS to quantify the stimulation evoked motor behaviour and found low stimulation frequency (5–30 Hz) evoked motor behaviour similar to human tremor or dyskinesia [ 144 ]. Sheep, therefore, offer the opportunity for a suitable model of human PD because of their large brain and body weight; however, the slow degeneration of dopamine neurons has yet to be emulated.…”

Section: The Use Of Sheep To Model Human Diseases In Biomedical Researchmentioning

confidence: 99%

The Sheep as a Large Animal Model for the Investigation and Treatment of Human Disorders

Banstola

Reynolds

2022

Biology

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An essential aim of biomedical research is to translate basic science information obtained from preclinical research using small and large animal models into clinical practice for the benefit of humans. Research on rodent models has enhanced our understanding of complex pathophysiology, thus providing potential translational pathways. However, the success of translating drugs from pre-clinical to clinical therapy has been poor, partly due to the choice of experimental model. The sheep model, in particular, is being increasingly applied to the field of biomedical research and is arguably one of the most influential models of human organ systems. It has provided essential tools and insights into cardiovascular disorder, orthopaedic examination, reproduction, gene therapy, and new insights into neurodegenerative research. Unlike the widely adopted rodent model, the use of the sheep model has an advantage over improving neuroscientific translation, in particular due to its large body size, gyrencephalic brain, long lifespan, more extended gestation period, and similarities in neuroanatomical structures to humans. This review aims to summarise the current status of sheep to model various human diseases and enable researchers to make informed decisions when considering sheep as a human biomedical model.

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“…A sheep model inducing a persistent Parkinsonian state with the administration of the neurotoxin MPTP has proven to be an efficient translational research model [ 2 ]. Furthermore, a Parkinson’s disease treatment study into electrode stimulation of the ovine subthalamic nucleus deemed them as a viable large-animal model for deep brain stimulation side effects [ 3 ]. Focal seizure activity visualized in sheep subjects injected with local penicillin in their right prefrontal cortex has provided an effective model for investigating epilepsy with intracranial electroencephalography (EEG) [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Implementation of a Corriedale Ovine Brain Atlas for Use in Atlas-Based Segmentation

et al. 2016

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Segmentation is the process of partitioning an image into subdivisions and can be applied to medical images to isolate anatomical or pathological areas for further analysis. This process can be done manually or automated by the use of image processing computer packages. Atlas-based segmentation automates this process by the use of a pre-labelled template and a registration algorithm. We developed an ovine brain atlas that can be used as a model for neurological conditions such as Parkinson’s disease and focal epilepsy. 17 female Corriedale ovine brains were imaged in-vivo in a 1.5T (low-resolution) MRI scanner. 13 of the low-resolution images were combined using a template construction algorithm to form a low-resolution template. The template was labelled to form an atlas and tested by comparing manual with atlas-based segmentations against the remaining four low-resolution images. The comparisons were in the form of similarity metrics used in previous segmentation research. Dice Similarity Coefficients were utilised to determine the degree of overlap between eight independent, manual and atlas-based segmentations, with values ranging from 0 (no overlap) to 1 (complete overlap). For 7 of these 8 segmented areas, we achieved a Dice Similarity Coefficient of 0.5–0.8. The amygdala was difficult to segment due to its variable location and similar intensity to surrounding tissues resulting in Dice Coefficients of 0.0–0.2. We developed a low resolution ovine brain atlas with eight clinically relevant areas labelled. This brain atlas performed comparably to prior human atlases described in the literature and to intra-observer error providing an atlas that can be used to guide further research using ovine brains as a model and is hosted online for public access.

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Motor behaviors in the sheep evoked by electrical stimulation of the subthalamic nucleus

Cited by 6 publications

References 95 publications

Long Term Performance of a Bi-Directional Neural Interface for Deep Brain Stimulation and Recording

Long Term Performance of a Bi-Directional Neural Interface for Deep Brain Stimulation and Recording

The Sheep as a Large Animal Model for the Investigation and Treatment of Human Disorders

Development and Implementation of a Corriedale Ovine Brain Atlas for Use in Atlas-Based Segmentation

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