Motor associations of iron accumulation in deep grey matter nuclei in Parkinson's disease: a cross‐sectional study of iron‐related magnetic resonance imaging susceptibility

Martín-Bastida, Antonio; Lao–Kaim, Nicholas P; Loane, Clare; Politis, Marios; Roussakis, Andreas–Antonios; Valle‐Guzman, Natalie; Kefalopoulou, Zinovia; Paul-Visse, Gesine; Widner, Håkan; Xing, Yue; Schwarz, ST; Auer, Dorothee P.; Foltynie, Thomas; Barker, Roger A.; Piccini, Paola

doi:10.1111/ene.13208

Cited by 52 publications

(36 citation statements)

References 38 publications

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“…SWI studies showed lower levels of phase radians in the substantia nigra pars compacta as well as in the caudate nuclei and red nucleus, with higher phase shift in substantia nigra pars compacta and basal ganglia, were found in PD patients, indicating an increased iron content which correlated with UPDRS scores (Martin-Bastida et al, 2017;Zhang et al, 2009Zhang et al, , 2010.…”

Section: Iron Deposition and Neuromelaninmentioning

confidence: 91%

Imaging in Parkinson's Disease

Politis

Pagano

Niccolini

2017

International Review of Neurobiology

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Section: Iron Deposition and Neuromelaninmentioning

confidence: 91%

Imaging in Parkinson's Disease

Politis

Pagano

Niccolini

2017

International Review of Neurobiology

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“…Поэтому в нашей работе, помимо основных клинических параметров, анализировались нарушения ходьбы, депрессия, расстройства сна и когнитивная дисфункция. Этим объясняется отличие полученных нами результатов от данных других авторов, анализировавших степень накопления железа в зависимости от оценки по UPDRS, раннего или позднего начала, длительности заболевания [17][18][19].…”

Section: н е к о т о р ы е к л и н и ч е с к и е п о к а з а т е л и unclassified

“…При сравнительном анализе содержания железа в исследуемых областях не получено значимых различий у пациентов со II и III стадиями БП. Расхождения с некоторыми зарубежными исследованиями [13,17,18] можно объяснить наличием в них группы сравнения в виде здоровых лиц, в то время как при сопоставлении пациентов с разными стадиями БП также были получены разнонаправленные результаты [13,14].…”

Section: н е к о т о р ы е к л и н и ч е с к и е п о к а з а т е л и unclassified

Susceptibility-weighted MR imaging (SWI) of basal ganglia iron deposition in the early and advanced stages of Parkinson's disease

Trufanov

Yurin

Buriak

et al. 2019

RJTAO

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Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease and the first one among the nosological entities of parkinsonism. Susceptibility-weighted imaging (SWI), magnetic resonance imaging (MRI) pulse sequence, which allows the in vivo estimation of the values of iron deposition in different areas of the brain, is a potential technique for the early diagnosis of PD and for the study of the pathogenesis of its complications.Objective: to compare the values of iron deposition in the basal ganglia in Stages II and III PD and to determine the relationship of clinical findings to the level of iron deposition according to the SWI findings.Patients and methods. Twenty-four patients with Hoehn and Yahr Stages II (n=24) and III (n=12) PD were examined. All the patients underwent brain MRI on a Siemens TrioTim (3T) MRI scanner by using pulse sequences T1, T2, SWI and subsequently quantifying the iron deposition (SPIN software). The accumulation of iron is visualized as an area of reduced signal intensity on SWI, and its estimation in accordance with the SPIN program has accordingly a smaller value. The regions of interest on both sides were the dentate nucleus, substantia nigra, red nucleus, putamen, globus pallidus, and head of the caudate nucleus. The examination protocol also included tests using the following scales: the Unified Parkinson's Disease Rating Scale (UPDRS), the Mini-Mental State Examination (MMSE), Frontal Assessment Batter (FAB), Freezing of Gait (FOG), Gait and Balance Scale (GABS), the Epworth Daytime Sleepiness Scale, the Parkinson's Disease Quality of Life Questionnaire (PDQ), the Beck Depression Inventory, and the Clock-Drawing Test.Results and discussion. The investigators found significant (p<0.05) correlations between the clinical picture and the level of iron deposition in the regions of interest in patients with Stage II PD: FOG – left caudate nucleus (r=-0.94); GABS – left caudate nucleus (r=-0.94); and in patients with stage III of the disease: UPDRS (full) – left red nucleus (r=-0.82), right globus pallidus (r=-0,80), left putamen (r=-0,96); UPDRS (Section 2) – left red nucleus (r=-0.77), left globus pallidus (r=-0.84); UPDRS (Section 3) – right putamen (r=-0,85), right globus pallidus (r=-0.78), left globus pallidus (r=-0,92); FOG – left globus pallidus (r=-0.81); GABS – left red nucleus (r=-0.96), left putamen (r=0.82), right putamen (r=-0.89), left globus pallidus (r=-0.82), right globus pallidus (r=-0.85), left caudate nucleus (r=-0.82), right caudate nucleus (r=-0.89); Beck Depression Inventory – right substantia nigra (r=-0.82).Conclusion. SWI measurement of the values of iron deposition in the structures of the extrapyramidal system in PD provides an additional insight into the pathological processes occurring in them.

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“…Only one article finds an increase in iron in the RN, CN, or pulvinar thalamus (PT) while three articles find an increase in iron in the PUT . Several authors found that there was a correlation of the increase in iron content with the Unified Parkinson Disease Rating Scale scores but not all studies found such agreement. Two articles found a correlation of iron content with serum ceruloplasmin levels …”

Section: Applications Of Iron Quantification In Neurodegenerative Dismentioning

confidence: 99%