Motor and sensory neurons of the rat sural nerve: A horseradish peroxidase study

Peyronnard, Jean‐Marie; Charron, Louise

doi:10.1002/mus.880050811

Cited by 80 publications

(38 citation statements)

References 33 publications

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“…Janig & McLachlan (1984) and Peyronnard et al (1986 a) have tried this experiment. Both groups have obtained reproducible results from normal material, both in rats and cats, with reasonably consistent matches between the numbers of axons in the nerves and the numbers of labelled cells in the dorsal root and sympathetic ganglia (McLachlan & Janig, 1983;Peyronnard & Charron, 1982;Peyronnard et al 1986a, b;Baron et al 1988). In injured nerves where a stump neuroma had been made to form, however, fewer somata were labelled.…”

Section: Articular Nervesmentioning

confidence: 66%

Regeneration of Unmyelinated Axons After Injury of Mammalian Peripheral Nerve

Lisney

1989

Exp Physiol

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Section: Articular Nervesmentioning

confidence: 66%

Regeneration of Unmyelinated Axons After Injury of Mammalian Peripheral Nerve

Lisney

1989

Exp Physiol

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“…After neonatal transection of the sciatic nerve, the sciatic nerve stump and its associated L,-L, dorsal root ganglia and roots (Kaizawa and Takahashi, 1970;Peyronnard and Charron, 1982;Rodin et al, 1983;Wall and Devor, 1981;Wiley and Wall, 1983) were smaller than normal. This is consistent with reports of loss of sensory cell bodies in dorsal root ganglia after nerve injury in young mammals (Aldskogius and Risling, 198 1, 1983;Jorgensen and Dyck, 1979;Ranson, 1906;Risling et al, 1983;Yip and Johnson, 1984) and with the proposition that the patterns of cortical change after neonatal sciatic injury involve alterations in the capacity of the injured nerve to support normal development of the ascending hindpaw projection system.…”

Section: Present Jindingsmentioning

confidence: 97%

The representation of peripheral nerve inputs in the S-I hindpaw cortex of rats raised with incompletely innervated hindpaws

Wall¹,

Cusick²

1986

J. Neurosci.

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The hindpaws of l-d-old rats were partially denervated by transection and ligation of the sciatic nerve. Following growth to adulthood, the topographical organization of the hindpaw representation in primary somatosensory (S-I) cortex was studied with neurophysiological mapping techniques and compared to the organization of previously studied normal adult rats and adult rats that had sciatic transection. The goals were (1) to determine how the topographical organization of the hindpaw representation is affected when development occurs with an incomplete set of peripheral inputs, and (2) to identify possible differences in the capacity of neonatal and adult CNSs to adjust to loss of inputs.The rat hindpaw is relatively immature on the day of birth. Neonatal transection and ligation of the sciatic nerve stunted gross development of the hindpaw and resulted in a permanent loss of low-threshold mechanoreceptor inputs from hindpaw zones normally innervated by the sciatic nerve.A comparison of the cortical representations of neonatally denervated and normal rats indicated that early loss of sciatic inputs caused several changes in the topographical organization of the hindpaw cortex, including (1) a loss of the representation of hindpaw skin areas innervated by the sciatic nerve, (2) a limited infringement of cutaneous inputs from the hindquarter into the cortical zone deprived of sciatic hindpaw inputs, (3) increased variability in the topographical relationships of the hindpaw and hindquarter representations, and (4) a decrease in the size of the cortical area responsive to cutaneous inputs.A comparison of the cortical representations of neonatal and adult denervates indicated that the general cortical reaction to sciatic injury at both ages was similar: Neurons in some parts of the deprived hindpaw cortex were activated by cutaneous inputs from uninjured nerves, whereas neurons in other parts of this cortex were unresponsive to cutaneous stimulation. The topographical organization and size of projection zones of uninjured peripheral inputs were different, however, after denervation in neonatal and adult rats.From these findings we suggest that (1) development of a normal, topographically organized hindpaw representation requires integration of hindpaw inputs in a spatially specific manner, (2) more than one pattern of cortical adjustment occurs after sciatic injury, and age is an important determinant of the pattern that is established, and (3) different mechanisms of central adjustment underlie age-related differences in cortical pat-

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“…In our experimental model, the sural nerve was used as the donor, which seems to be very suitable for studying the sprouting specifically of myelinated sensory axons, because > 93% of its myelinated axons are sensory. 58,59 Several observations discussed in detail in our previous papers 11,57,60 demonstrated that in our experimental model the axons in the recipient nerve were axon sprouts (either collateral from uninjured axons or regenerative from injured axons) from the donor nerve, and ruled out the possibility of inadvertent invasion of the regenerating axons from some other source, for example, from the proximal nerve stumps of the transected adjacent peroneal and tibial nerves.…”

Section: Discussionmentioning

confidence: 58%

Influence of Breaching the Connective Sheaths of the Donor Nerve on Its Myelinated Sensory Axons and on Their Sprouting into the End-to-Side Coapted Nerve in the Rat

Kovačič

Žele²,

Tomšič³

et al. 2012

Journal of Neurotrauma

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The influence of breaching the connective sheaths of the donor sural nerve on axonal sprouting into the end-to-side coapted peroneal nerve was examined in the rat. In parallel, the effect of these procedures on the donor nerve was assessed. The sheaths of the donor nerve at the coaptation site were either left completely intact (group A) or they were breached by epineurial sutures (group B), an epineurial window (group C), or a perineurial window (group D). In group A, the compound action potential (CAP) of sensory axons was detected in *10% and 40% of the recipient nerves at 4 and 8 weeks, respectively, which was significantly less frequently than in group D at both recovery periods. In addition, the number of myelinated axons in the recipient nerve was significantly larger in group D than in other groups at 4 weeks. At 8 weeks, the number of axons in group A was only *15% of the axon numbers in other groups ( p < 0.05). Focal subepineurial degenerative changes in the donor nerves were only seen after 4 weeks, but not later. The average CAP area and the total number of myelinated axons in the donor nerves were not different among the experimental groups. In conclusion, myelinated sensory axons are able to penetrate the epiperineurium of donor nerves after end-to-side nerve coaption; however, their ingrowth into recipient nerves is significantly enhanced by breaching the epiperineurial sheets at the coaptation site. Breaching does not cause permanent injury to the donor nerve.

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Motor and sensory neurons of the rat sural nerve: A horseradish peroxidase study

Cited by 80 publications

References 33 publications

Regeneration of Unmyelinated Axons After Injury of Mammalian Peripheral Nerve

Regeneration of Unmyelinated Axons After Injury of Mammalian Peripheral Nerve

The representation of peripheral nerve inputs in the S-I hindpaw cortex of rats raised with incompletely innervated hindpaws

Influence of Breaching the Connective Sheaths of the Donor Nerve on Its Myelinated Sensory Axons and on Their Sprouting into the End-to-Side Coapted Nerve in the Rat

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