Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease

Ghika, Apostolia; Kyrozis, Andreas; Potagas, Constantinos; Louis, Elan D.

doi:10.7916/d83777wk

Cited by 13 publications

(6 citation statements)

References 34 publications

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“…In our cohort, the HAMD, HAMA, MMSE, and MoCA scores did not differ between ET-PD and ET/t-PD. However, constipation, hyposmia, and RBD were more common in the t-PD group than the ET-PD group, while hyposmia, rather than constipation or RBD, was more common in the ET-PD group than the ET group, which was consistent with previous studies (5,25). Another study found no significant differences between patients with ET-PD and ET with regard to non-motor features (10).…”

Section: Discussionsupporting

confidence: 90%

“…A long latency could be up to 50 years (24). Like previous studies (6,25), we found that the average latency for ET patients to develop PD was 12.30 ± 2.18 years. Furthermore, in the ET-PD group, the age of onset of ET tended to be older than that in the ET group, while the age of onset of PD was older than that in the t-PD group.…”

Section: Discussionsupporting

confidence: 84%

“…Furthermore, in the ET-PD group, the age of onset of ET tended to be older than that in the ET group, while the age of onset of PD was older than that in the t-PD group. There was no significant difference between the ET-PD and ET groups concerning sex, which is in accordance with a previous study (25) but conflicts with another study that reported a male predominance of ET-PD (26). It may need a further prospective study to explore the epidemiological characteristics of ET-PD.…”

Section: Discussionsupporting

confidence: 74%

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Clinical Characteristics and Electrophysiological Biomarkers of Parkinson's Disease Developed From Essential Tremor

et al. 2020

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Background and Objective: Parkinson's disease developed from essential tremor (ET-PD) is a distinct clinical syndrome that is different from essential tremor (ET) and Parkinson's disease (PD). There is currently a lack of research on ET-PD. Tremor characteristics (amplitude and frequency) are primary quantitative indexes for diagnosing and monitoring of tremors. In this study, we aimed to explore specific clinical and electrophysiological biomarkers for the identification of ET-PD. Methods:The study included patients with ET-PD (n = 22), ET (n = 42), and tremor-dominant PD (t-PD, n = 47). We collected demographic data, clinical characteristics (including motor and non-motor symptoms), and tremor analysis. The frequency, amplitude, contracting patterns of resting tremor and postural tremor were collected. The analysis of ET-PD and ET/t-PD was compared. The receiver operating characteristic (ROC) curve was used to analyze the electrophysiological features in distinguishing ET-PD from ET or t-PD.Results: Compared with ET, hyposmia, bradykinesia, rigidity, postural abnormality, and resting tremor were more common in the ET-PD group (P = 0.01, 0.003, 0.001, 0.001, 0.019, respectively). The postural tremor frequencies of the head, upper limbs, and lower limbs were significantly lower in the ET-PD than in the ET (P = 0.007, 0.003, 0.035, respectively), which were the most appropriate variables for distinguishing ET-PD from ET (AUC: 0.775, 0.727, and 0.701, respectively). Compared with t-PD, bradykinesia, rigidity, postural abnormality (both P < 0.001), and resting tremor (P = 0.024) were less common in the ET-PD. The postural tremor amplitudes of the head and upper limbs were significantly higher in the ET-PD than in the t-PD (P = 0.022, 0.001, respectively), which were the most appropriate variables for distinguishing ET-PD from t-PD (AUC: 0.793 and 0.716). Conclusions:Hyposmia and electrophysiological biomarkers (postural tremor frequencies and amplitudes) help early recognition of ET-PD.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 74%

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Clinical Characteristics and Electrophysiological Biomarkers of Parkinson's Disease Developed From Essential Tremor

et al. 2020

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“…Given the overlap in some features, the nature of a link between ET and PD has been a subject of numerous studies [2,3,[74][75][76][77][78][79][80][81][82][83][84][85]. The reported prevalence of PD in patients with ET varies between 6.1% [86] and 26.0% [53].…”

Section: Essential Tremormentioning

confidence: 99%

“…As noted above, a subset of ET patients later develops PD (ET-PD), but it is difficult to predict which ET patients have a higher risk for later developing PD. In a study comparing 54 ET-PD and 121 ET patients, ET-PD patients were significantly more likely to have an asymmetric onset (68.5% vs 14.9%, p < 0.001) and RBD (51.9% vs 10.0%, p < 0.001) [75]. Interestingly, ET and PD symptoms appear to be more severe on the same side as the original ET [79,89].When compared to PD patients, ET-PD patients have been found to have more severe rest and action tremor, and more frequent family history of tremor [74].…”

Section: Essential Tremormentioning

confidence: 99%

Parkinsonism and tremor syndromes

Bellows

Jankovic

2022

Journal of the Neurological Sciences

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Etiologic links between environmental and lifestyle factors and Essential tremor

Ong

Deng

Tan

2019

Ann Clin Transl Neurol

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Essential tremor (ET) is one of the most common adult movement disorders, characterized by clinical tremor and other nonmotor symptoms. It is a progressive disease that shares features with other neurodegenerative diseases. ET is a complex disease with both genetic and environmental underpinnings. While genetic forms of ET are well recognized, the role of environmental and lifestyle factors in ET has been debated. Studies suggest that exposure to neurotoxic compounds such as β ‐carboline alkaloids and ethanol are potential risk factors for ET, while antioxidant intake may be protective. In addition, smoking acts as a protective factor in ET, parallel to its effects in other neurological diseases. New evidence points to pesticide and lead exposure as potential risk factors. There is growing evidence to suggest that environmental and lifestyle factors play a role in ET but additional research is needed in order to completely understand their cause and effect association. There is also a need for larger case‐control and prospective cohort studies across different populations to further evaluate the etiological importance of these factors in ET.

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Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease

Cited by 13 publications

References 34 publications

Clinical Characteristics and Electrophysiological Biomarkers of Parkinson's Disease Developed From Essential Tremor

Clinical Characteristics and Electrophysiological Biomarkers of Parkinson's Disease Developed From Essential Tremor

Parkinsonism and tremor syndromes

Etiologic links between environmental and lifestyle factors and Essential tremor

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