Motor and electrocorticographic epileptic activity induced by 3-mercaptopropionic acid in immature rats

Mareš, Pavel; Kubová, Hana; Zouhar, A; Folbergrová, Jaroslava; Koryntová, H; Stanková, L

doi:10.1016/0920-1211(93)90034-5

Cited by 25 publications

(7 citation statements)

References 28 publications

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“…Previously we described the higher sensitivity of 18-dayold rats to effects of some convulsant drugs, e.g. PTZ (Veli-Sek et al 1992); 3-mercaptopropionic acid (MareS et al 1993); homocysteine (Kubova et al, in press), but this phenomenon cannot be generalized for all convulsants and/or convulsive stimuli. NMDA and kainic acid were found to be more efficient in 7-day-old than in all older rats (Mar-eS & VeliSek 1992;VeliSkova et al 1988).…”

Section: Discussionmentioning

confidence: 90%

Different Postnatal Development of Convulsions and Lethality Induced by Strychnine in Rats

Kubová

Mareš

1995

Pharmacology & Toxicology

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The convulsant action of strychnine was studied in 310 male albino rats, aged 3 to 25 days. Doses of 0.25-4 mg/kg were administered intraperitoneally and the animals were observed for 30 min. Generalized tonic-clonic seizures involving also tonic hindlimb extension occurred in all age groups. The convulsant effects of strychnine increased from day 3 to day 18, and decreased again from day 25, as indicated by the incidence and latencies of seizures. Lethal effects did not occur before day 12. Hyperactivity was seen as the first sign of strychnine action in rats during the first week of life, automatisms predominating in 18-day-old animals. Electroencephalographic study in 30 rat pups with implanted electrodes demonstrated an extremely poor electro-clinical correlation.

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Section: Discussionmentioning

confidence: 90%

Different Postnatal Development of Convulsions and Lethality Induced by Strychnine in Rats

Kubová

Mareš

1995

Pharmacology & Toxicology

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“…This evidence suggests that developmental seizure studies may be extremely important in designing new, effective, age-specific AED regimens, y-Aminobutyric acid (GABA)-mediated inhibition has a strong impact on the developmental expression of seizures. Systemic infusions of 3-mercaptopropionic acid, a drug that decreases GABA synthesis, induce age-specific seizures in rats (Mares et al, 1993). The GABAA antagonists bicuculline and picrotoxin also induce seizures with agespecific features throughout development (de Feo et al, 1985;Zouhar et al, 1989;Baram and Snead 111, 1990;de Feo and Mecarelli, 1993).…”

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confidence: 99%

Age‐Dependent Effects of γ‐Aminobutyric Acid Agents on Flurothyl Seizures

et al. 1995

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Behavioral characteristics of seizures have age-dependent features, which suggests that effective treatment of seizures may be age-specific as well. In experiments that used the flurothyl seizure model, we examined the effects of several drugs that affect GABAergic neurotransmission in rats of various ages. Systemic administration of phenobarbital (PB, a drug that enhances GABAA receptor-mediated inhibition) was anticonvulsant in most age groups. In contrast, gamma-vinyl GABA (VGB, a drug that increases endogenous GABA levels and enhances both GABAA and GABAB receptor transmission) did not have anticonvulsant effects. Baclofen (a GABAB receptor agonist) was proconvulsant in 9-day-old rat pups, and anticonvulsant in 15-30-day-old rats and lost its anticonvulsant activity in 60-day-old rats. CGP 35348 (a GABAB receptor antagonist) was proconvulsant in developing rats but not in 60-day-old rats. A novel GABAB receptor antagonist, CGP 36742, was proconvulsant in 9- and 15-day-old rats but had no effects in 30- and 60-day-old rats. These results indicate that the effects of presumed GABAergic agents are not uniform across the age span. The differences may reflect age-dependent maturational changes of GABA receptor subtypes, differential action of the drugs on pre- and postsynaptic sites and possible non-GABAergic effects.

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“…The inhibition of seizures induced by 3-MP acid is a well-established method with which drugs with effects on the GABAergic system are evaluated [18]. Mice were divided into 5 groups ( n = 8 in each group).…”

Section: Methodsmentioning

confidence: 99%

Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies

Nóbrega

Salvadori

Masson

et al. 2014

Oxidative Medicine and Cellular Longevity

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Terpinen-4-ol (4TRP) is a monoterpenoid alcoholic component of essential oils obtained from several aromatic plants. We investigated the psychopharmacological and electrophysiological activities of 4TRP in male Swiss mice and Wistar rats. 4TRP was administered intraperitoneally (i.p.) at doses of 25 to 200 mg/kg and intracerebroventricularly (i.c.v.) at concentrations of 10, 20, and 40 ng/2 μL. For in vitro experiments, 4TRP concentrations were 0.1 mM and 1.0 mM. 4TRP (i.p.) inhibited pentylenetetrazol- (PTZ-) induced seizures, indicating anticonvulsant effects. Electroencephalographic recordings showed that 4TRP (i.c.v.) protected against PTZ-induced seizures, corroborating the behavioural results. To determine whether 4TRP exerts anticonvulsant effects via regulation of GABAergic neurotransmission, we measured convulsions induced by 3-mercapto-propionic acid (3-MP). The obtained results showed involvement of the GABAergic system in the anticonvulsant action exerted by 4TRP, but flumazenil, a selective antagonist of the benzodiazepine site of the GABAA receptor, did not reverse the anticonvulsant effect, demonstrating that 4TRP does not bind to the benzodiazepine-binding site. Furthermore, 4TRP decreased the sodium current through voltage-dependent sodium channels, and thus its anticonvulsant effect may be related to changes in neuronal excitability because of modulation of these channels.

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Motor and electrocorticographic epileptic activity induced by 3-mercaptopropionic acid in immature rats

Cited by 25 publications

References 28 publications

Different Postnatal Development of Convulsions and Lethality Induced by Strychnine in Rats

Different Postnatal Development of Convulsions and Lethality Induced by Strychnine in Rats

Age‐Dependent Effects of γ‐Aminobutyric Acid Agents on Flurothyl Seizures

Monoterpenoid Terpinen-4-ol Exhibits Anticonvulsant Activity in Behavioural and Electrophysiological Studies

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