Motor and cognitive outcomes of low birth weight neonates born in a limited resource country: a systematic review

Abstract

Objective: To examine the outcomes of motor and cognitive development among neonates born with low birth weight (LBW) or very low birth weight (VLBW). Data sources: Systematic review carried out in PubMed, Cochrane Library and Web of Science using the search strategy using combinations of the following keywords and terms: preterm birth OR prematurity OR premature Infants OR premature children AND low birth weight children OR very low birth weight children AND neurodevelopment OR cognitive development OR Motor development OR follow up AND humans. Articles searched were published from inception until July, 2019, and involved children born and evaluated in Brazil. The bias risk analysis was adapted from the STROBE scale, used to evaluate the methodology of the included studies. Data synthesis: The search identified 2,214 publications. After screening for titles and abstracts and removing duplicate entries, full texts of 38 articles were reviewed. After reading full texts, 24 articles met the inclusion criteria (articles in Portuguese and English), dated from 1998 to 2017). Endnote Version X9 software was used for data extraction. Two reviewers performed the literature search and study selection independently. Disagreements were solved by consensus or by a third reviewer. Results: it was evidenced an inferior motor development of children with LBW when compared to the control population, the standardized mean difference of [-1.15 (95% CI -1.56, -0.73), I2 80%], children with LBW have lower cognitive development according the standardized mean difference of [-0,71 (95% CI -0.99, -0.44) I2 67%]. Conclusion: Our review reinforces that impaired motor and cognitive outcome is a significant long-term outcome associated with LBW. The risk of impairment in those domains increases with decreasing gestational age. Keywords: Motor development; outcome; prematurity; preterm infants; systematic review.