Motor activity and perception of sleep in depressed patients

Lemke, Matthias R.; Puhl, P.; Broderick, Alesia

doi:10.1016/s0022-3956(98)00067-3

Cited by 42 publications

(32 citation statements)

References 20 publications

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“…Motor activity was defined as "day-time" between 6 a.m. and 10 p.m. and as "night-time" between 10 p.m. and 6 a.m., matching the waking-times and bedtimes in the hospital. In order to obtain periods of equal durations for the statistical analysis, day-time was divided into a morning period (6 a.m. to 2 p.m.) and an afternoon/ evening period (2-10 p.m.) (Lemke et al 1999). Primary independent variables were the 5-HTTLPR genotype and the type of antidepressant medication.…”

Section: Discussionmentioning

confidence: 99%

Evidence of a role for the 5-HTTLPR genotype in the modulation of motor response to antidepressant treatment

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Evidence of a role for the 5-HTTLPR genotype in the modulation of motor response to antidepressant treatment

et al. 2004

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“…26,27 In addition, in symptomatic patients with major depression, the severity of depression is associated with greater nocturnal activity assessed by actigraphy and also poorer self-reported sleep quality. 35 However, in the present study on a nonpsychiatric sample, there was no significant association between depressive symptoms and awake physical activity assessed by actigraphy.…”

Section: Depression and Physical Activitymentioning

confidence: 99%

“…An increase in nocturnal physical activity, which is sometimes used as an indicator of sleep quality, 24 and a decrease in awake physical activity are associated with less dipping of BP. 25 Major depression and anxiety are often characterized by poor sleep quality and altered physical activity levels, 2,26,27 which might predict disruption of the diurnal BP variation and an increased risk of cardiovascular disease. However, the relationship between depression and diurnal BP variation in nonpsychiatric samples is not clear.…”

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confidence: 99%

Gender Differences in Associations of Diurnal Blood Pressure Variation, Awake Physical Activity, and Sleep Quality With Negative Affect

et al. 2001

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Abstract-This study reports on the associations among depression, anxiety, awake physical activity, sleep quality (assessed by nocturnal physical activity), and diurnal blood pressure (BP) variation in a nonpsychiatric sample (The Work Site Blood Pressure Study). We conducted ambulatory BP (ABP) monitoring and actigraphy in 231 working men and women. Depression and anxiety were measured by the Brief Symptom Inventory. There were gender-specific associations between depression or anxiety and ABP parameters. In men, depression was associated positively with the sleep/awake systolic BP (SBP) ratio (rϭ0.24, Pϭ0.006). After controlling for age, body mass index, and awake and sleep activity, depression remained significantly associated with the sleep/awake SBP ratio (rϭ0.25, Pϭ0.005) and was also significantly related to sleep SBP (rϭ0.21, Pϭ0.02). Anxiety, which was related to depression (rϭ0.73, PϽ0.0001), had a similar but slightly weaker pattern of associations with ABP and activity. These associations were not found in women, but there were associations of anxiety with awake SBP (rϭ0.24, Pϭ0.01) and pulse rate (rϭ0.27, Pϭ0.006). In conclusion, depression is associated with disrupted diurnal BP variation independent of ambulatory physical activity in working men, whereas anxiety is associated with awake SBP and pulse rate in women. here is growing evidence that depression is one of the most important psychological predictors of cardiovascular disease. 1 Depression and depressive symptoms are exceedingly common in the general population. 2 A large epidemiological study of Ͼ18 500 persons reported the lifetime prevalence rate of subthreshold depressive symptoms to be 23%. 3 Recent clinical studies have shown that depression and related conditions, such as anxiety, even at subthreshold levels, are independent predictors of hypertension and cardiovascular events (both coronary heart disease and stroke). 1,[3][4][5][6][7][8] In addition to activating the neuroendocrine system (sympathetic activity and hypothalamus-pituitaryadrenal [HPA] axis), major depression has also been reported to disrupt the diurnal rhythm of these neuroendocrine factors, which, in turn, are closely associated with blood pressure (BP). 2,6 There are clear gender differences in the prevalence of depression and related disorders. 9 Depressive symptoms and major depression are more common in women. 9 On the other hand, cardiovascular events and hypertension are less frequent in women, particularly before menopause. 10 Thus, the impact of depression on the cardiovascular system may be different between women and men.Ambulatory BP (ABP) monitoring (ABPM) performed in healthy subjects has shown that BP levels typically decrease during sleep, by 10% to 20% of the mean awake BP. 11 Several studies have recently found that an abnormal diurnal BP variation, characterized by diminished nocturnal BP dipping, is associated with silent and clinical cardiovascular disease. [12][13][14][15][16][17] This diminished nocturnal BP dipping is hypothesized to be cause...

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“…All of these groups are thought to represent poor sleepers and have been discriminated as such by the PSQI global score. Among the groups that have been studied using the PSQI are chronic pain patients, 5,6 sleep disorders patients, 4,9,10 cancer patients, 11 irritable bowel syndrome patients, 12 depressed patients, [13][14][15] family caregivers, 16 fibromyalgia patients, 17 blind patients, 18 HIV patients, [19][20][21] Holocaust survivors, 22 elderly people 7,23 and patients with traumatic brain injury. 3 It is uncertain, however, what the common element of "poor sleep quality" might be among these diverse groups, although all may tend to be depressed.…”

Section: Introductionmentioning

confidence: 99%

Criterion validity of the Pittsburgh Sleep Quality Index: Investigation in a non-clinical sample

Grandner

Kripke

Yoon

et al. 2006

Sleep and Biological Rhythms

370

241

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The objective of this study was to investigate the reliability and validity of the Pittsburgh Sleep Quality Index (PSQI) in a non-clinical sample consisting of younger and older adults. There has been little research validating the PSQI with respect to multinight recording as with actigraphy, and more validation is needed in samples not specifically selected for clinical disturbance. Also, the degree to which the PSQI scores may reflect depressive symptoms versus actual sleep disturbance remains unclear. One-hundred and twelve volunteers (53 younger and 59 older) were screened for their ability to perform treadmill exercises; inclusion was not based on sleep disturbance or depression. Internal homogeneity was evaluated by correlating PSQI component scores with the global score. Global and component scores were correlated with a sleep diary, actigraphy, and centers for epidemiological studies -depression scale scores to investigate criterion validity. Results showed high internal homogeneity. PSQI global score correlated appreciably with sleep diary variables and the depression scale, but not with any actigraphic sleep variables. These results suggest that the PSQI has good internal homogeneity, but may be less reflective of actual sleep parameters than a negative cognitive viewpoint or pessimistic thinking. The sleep complaints measured may often be more indicative of general dissatisfaction than of any specifically sleep-related disturbance.

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Motor activity and perception of sleep in depressed patients

Cited by 42 publications

References 20 publications

Evidence of a role for the 5-HTTLPR genotype in the modulation of motor response to antidepressant treatment

Evidence of a role for the 5-HTTLPR genotype in the modulation of motor response to antidepressant treatment

Gender Differences in Associations of Diurnal Blood Pressure Variation, Awake Physical Activity, and Sleep Quality With Negative Affect

Criterion validity of the Pittsburgh Sleep Quality Index: Investigation in a non-clinical sample

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