Motor Activity and Daily Variation of Symptom Intensity in Depressed Patients

Lemke, Matthias R.; Broderick, Alesia; Zeitelberger, Martin; Hartmann, Wolfgang

doi:10.1159/000119362

Cited by 38 publications

(25 citation statements)

References 14 publications

(35 reference statements)

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“…26,27 In addition, in symptomatic patients with major depression, the severity of depression is associated with greater nocturnal activity assessed by actigraphy and also poorer self-reported sleep quality. 35 However, in the present study on a nonpsychiatric sample, there was no significant association between depressive symptoms and awake physical activity assessed by actigraphy. In addition, sleep activity, an indicator of sleep quality, was also not associated with depressive symptoms.…”

Section: Depression and Physical Activitycontrasting

confidence: 84%

Gender Differences in Associations of Diurnal Blood Pressure Variation, Awake Physical Activity, and Sleep Quality With Negative Affect

et al. 2001

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Abstract-This study reports on the associations among depression, anxiety, awake physical activity, sleep quality (assessed by nocturnal physical activity), and diurnal blood pressure (BP) variation in a nonpsychiatric sample (The Work Site Blood Pressure Study). We conducted ambulatory BP (ABP) monitoring and actigraphy in 231 working men and women. Depression and anxiety were measured by the Brief Symptom Inventory. There were gender-specific associations between depression or anxiety and ABP parameters. In men, depression was associated positively with the sleep/awake systolic BP (SBP) ratio (rϭ0.24, Pϭ0.006). After controlling for age, body mass index, and awake and sleep activity, depression remained significantly associated with the sleep/awake SBP ratio (rϭ0.25, Pϭ0.005) and was also significantly related to sleep SBP (rϭ0.21, Pϭ0.02). Anxiety, which was related to depression (rϭ0.73, PϽ0.0001), had a similar but slightly weaker pattern of associations with ABP and activity. These associations were not found in women, but there were associations of anxiety with awake SBP (rϭ0.24, Pϭ0.01) and pulse rate (rϭ0.27, Pϭ0.006). In conclusion, depression is associated with disrupted diurnal BP variation independent of ambulatory physical activity in working men, whereas anxiety is associated with awake SBP and pulse rate in women. here is growing evidence that depression is one of the most important psychological predictors of cardiovascular disease. 1 Depression and depressive symptoms are exceedingly common in the general population. 2 A large epidemiological study of Ͼ18 500 persons reported the lifetime prevalence rate of subthreshold depressive symptoms to be 23%. 3 Recent clinical studies have shown that depression and related conditions, such as anxiety, even at subthreshold levels, are independent predictors of hypertension and cardiovascular events (both coronary heart disease and stroke). 1,[3][4][5][6][7][8] In addition to activating the neuroendocrine system (sympathetic activity and hypothalamus-pituitaryadrenal [HPA] axis), major depression has also been reported to disrupt the diurnal rhythm of these neuroendocrine factors, which, in turn, are closely associated with blood pressure (BP). 2,6 There are clear gender differences in the prevalence of depression and related disorders. 9 Depressive symptoms and major depression are more common in women. 9 On the other hand, cardiovascular events and hypertension are less frequent in women, particularly before menopause. 10 Thus, the impact of depression on the cardiovascular system may be different between women and men.Ambulatory BP (ABP) monitoring (ABPM) performed in healthy subjects has shown that BP levels typically decrease during sleep, by 10% to 20% of the mean awake BP. 11 Several studies have recently found that an abnormal diurnal BP variation, characterized by diminished nocturnal BP dipping, is associated with silent and clinical cardiovascular disease. [12][13][14][15][16][17] This diminished nocturnal BP dipping is hypothesized to be cause...

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Section: Depression and Physical Activitycontrasting

confidence: 84%

Gender Differences in Associations of Diurnal Blood Pressure Variation, Awake Physical Activity, and Sleep Quality With Negative Affect

et al. 2001

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“…Correlations between clinical ratings and nighttime activity in MDD (22), as well as daytime activity in melancholic depression (23), indicate that day-night patterns of activity vary with symptom severity (24). For instance, severity of depression has been associated with amplitude and timing, particularly low amplitude and/or delayed daily peak activity (25), or circadian rhythm misalignment (26, 27).…”

Section: Introductionmentioning

confidence: 99%

Motor-Activity Markers of Circadian Timekeeping Are Related to Ketamine’s Rapid Antidepressant Properties

Duncan

Slonena

Hejazi

et al. 2017

Biological Psychiatry

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Background The rapid clinical antidepressant effects of the glutamatergic modulator ketamine may be due to its ability to restore synaptic plasticity and related effects on sleep-wake and circadian systems. Preclinical studies indicate that ketamine alters expression of circadian clock-associated molecules, and clinical studies of ketamine on plasticity-related biomarkers further suggest an association with sleep slow waves and sleep homeostasis. Methods Wrist activity monitors were used to examine the pharmacologic and rapid antidepressant effects of ketamine on markers of circadian timekeeping (amplitude and timing) in mood disorders. Circadian amplitude and timing of activity at baseline, post-infusion Day1 (D1), and Day3 (D3) were measured in 51 patients with major depressive disorder (MDD) or bipolar disorder (BD). Results Compared with either placebo or baseline, a mood-independent decrease of the central circadian value (mesor) was present on D1 after ketamine treatment. Mood-associated circadian effects between rapid (D1) responders and non-responders were found at baseline, D1, and D3. At baseline, a phase-advanced activity pattern and lower mesor distinguished subsequent responders from non-responders. On D1, ketamine non-responders had a lower mesor and a blunted 24-hour amplitude relative to baseline. On D3, patients with a persisting clinical response exhibited a higher amplitude and mesor compared with non-responders. Conclusions The findings are the first to demonstrate an association between ketamine’s clinical antidepressant effects and circadian timekeeping. The results suggest that trait-like circadian activity patterns indicate rapid mood response to ketamine, and that mediators of continuing ketamine-induced mood changes include altered timing and amplitude of the circadian system.

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“…In general, depressed patients show lower activity levels than controls, with associated higher mean heart rate and blood pressure [17]. Although a sample of depressed patients with melancholic features reported feeling less active and more depressed in the morning, they paradoxically showed higher levels of activity in the morning than the evening [18]. One study which examined the cortisol awakening response (CAR) found that depressed women showed a blunted CAR compared to non-depressed controls which was unrelated to time of waking or number of social contacts [19].…”

Section: Depression and Depression Symptomsmentioning

confidence: 99%

Ecological momentary assessment (EMA) of depression-related phenomena

Armey

Schatten

Haradhvala

et al. 2015

Current Opinion in Psychology

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Ecological momentary assessment (EMA) is one research method increasingly employed to better understand the processes that underpin depression and related phenomena. In particular, EMA is well suited to the study of affect (e.g., positive and negative affect), affective responses to stress (e.g., emotion reactivity), and behaviors (e.g., activity level, sleep) that are associated with depression. Additionally, EMA can provide insights into self-harm behavior (i.e. suicide and non-suicidal self-injury), and other mood disorders (e.g. bipolar disorder) commonly associated with depressive episodes. Given the increasing availability and affordability of handheld computing devices such as smartphones, EMA is likely to play an increasingly important role in the study of depression and related phenomena in the future.

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Motor Activity and Daily Variation of Symptom Intensity in Depressed Patients

Cited by 38 publications

References 14 publications

Gender Differences in Associations of Diurnal Blood Pressure Variation, Awake Physical Activity, and Sleep Quality With Negative Affect

Gender Differences in Associations of Diurnal Blood Pressure Variation, Awake Physical Activity, and Sleep Quality With Negative Affect

Motor-Activity Markers of Circadian Timekeeping Are Related to Ketamine’s Rapid Antidepressant Properties

Ecological momentary assessment (EMA) of depression-related phenomena

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