Motor activation in multiple system atrophy and Parkinson disease

Payoux, Pierre; Brefel‐Courbon, Christine; Ory-Magne, F.; Regragui, W.; Thalamas, Claire; Balduyck, S.; Durif, Franck; Tison, François; Blin, Olivier; Esquerré, J. P.; Rascol, Olivier

doi:10.1212/wnl.0b013e3181f4d78f

Cited by 25 publications

(26 citation statements)

References 32 publications

(27 reference statements)

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“…Hypoactivity in the SMA in our meta-analysis is well in line with previous task-related and resting-state fMRI, and positron emission tomography (PET) studies5152606162 and could be modulated by dopaminergic treatment in patients with PD526163. However, brain activation (hypoactivity or hyperactivity) in the lateral premotor cortex has not been always consistent in task-related fMRI or PET studies6263646566.…”

Section: Discussionsupporting

confidence: 85%

Abnormalities of regional brain function in Parkinson’s disease: a meta-analysis of resting state functional magnetic resonance imaging studies

Pan

Zhang

Liu

et al. 2017

Sci Rep

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There is convincing evidence that abnormalities of regional brain function exist in Parkinson’s disease (PD). However, many resting-state functional magnetic resonance imaging (rs-fMRI) studies using amplitude of low-frequency fluctuations (ALFF) have reported inconsistent results about regional spontaneous neuronal activity in PD. Therefore, we conducted a comprehensive meta-analysis using the Seed-based d Mapping and several complementary analyses. We searched PubMed, Embase, and Web of Science databases for eligible whole-brain rs-fMRI studies that measured ALFF differences between patients with PD and healthy controls published from January 1st, 2000 until June 24, 2016. Eleven studies reporting 14 comparisons, comparing 421 patients and 381 healthy controls, were included. The most consistent and replicable findings in patients with PD compared with healthy controls were identified, including the decreased ALFFs in the bilateral supplementary motor areas, left putamen, left premotor cortex, and left inferior parietal gyrus, and increased ALFFs in the right inferior parietal gyrus. The altered ALFFs in these brain regions are related to motor deficits and compensation in PD, which contribute to understanding its neurobiological underpinnings and could serve as specific regions of interest for further studies.

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Section: Discussionsupporting

confidence: 85%

Abnormalities of regional brain function in Parkinson’s disease: a meta-analysis of resting state functional magnetic resonance imaging studies

Pan

Zhang

Liu

et al. 2017

Sci Rep

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“…Previous research using PET has revealed reduced striatal presynaptic uptake and binding, glucose metabolism, and postsynaptic binding in both MSAp and PD [Bohnen et al, ; Ghaemi et al, ], but greater metabolic and postsynaptic binding reductions in MSAp compared with PD [Ghaemi et al, ]. A recent

{normalH}_{2}^{15} O

PET study also revealed reduced putaminal metabolism in MSAp compared with PD, but not controls, during a joystick hand movement task [Payoux et al, ]. Given that the joystick task did not activate the putamen in MSAp, PD, or controls, it may not be optimal for investigating between‐group differences in this region.…”

Section: Discussionmentioning

confidence: 96%

“…Another study that examined task‐related functional changes in MSAp using

{normalH}_{2}^{15} O

PET during joystick movements only found two cortical areas that differed between MSAp and PD, namely increased activation in the superior parietal cortex and SMA of MSAp [Payoux et al, ]. It is important to note that a recent meta‐analysis of motor task‐based fMRI and

{normalH}_{2}^{15} O

PET studies found that, while activation differed consistently in the pre‐SMA, SPL, and IPC between PD and controls, the direction of these differences did not [Herz et al, ].…”

Section: Discussionmentioning

confidence: 99%

“…r Multimodal MRI in PD and MSA r r 1173 r putaminal metabolism in MSAp compared with PD, but not controls, during a joystick hand movement task [Payoux et al, 2010]. Given that the joystick task did not activate the putamen in MSAp, PD, or controls, it may not be optimal for investigating between-group differences in this region.…”

Section: Discussionmentioning

confidence: 99%

“…This mixed pattern of results was found to be related in part to aspects of the tasks, suggesting that it is important to use the same task when comparing results between studies and groups. In MSA, only one study, which used

{normalH}_{2}^{15} O

PET, has investigated task‐related functional brain changes [Payoux et al, ]. It was shown that during joystick hand movements MSA patients had reduced activation in the cerebellum and increased activation in the SPL compared with controls and PD, and reduced activation in the putamen and increased activation in SMA compared with PD patients.…”

Section: Introductionmentioning

confidence: 99%

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Distinct functional and macrostructural brain changes in Parkinson's disease and multiple system atrophy

Planetta

Kurani

Shukla

et al. 2014

Human Brain Mapping

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Parkinson’s disease (PD) and the parkinsonian variant of multiple system atrophy (MSAp) are neurodegenerative disorders that can be difficult to differentiate clinically. This study provides the first characterization of the patterns of task-related functional magnetic resonance imaging (fMRI) changes across the whole brain in MSAp. We used fMRI during a precision grip force task and also performed voxel-based morphometry (VBM) on T1-weighted images in MSAp patients, PD patients, and healthy controls. All groups were matched on age, and the patient groups had comparable motor symptom durations and severities. There were three main findings. First, MSAp and PD had reduced fMRI activation in motor control areas, including the basal ganglia, thalamus, insula, primary sensorimotor and prefrontal cortices, and cerebellum compared with controls. Second, there were no activation differences among the disease groups in the basal ganglia, thalamus, insula, or primary sensorimotor cortices, but PD had more extensive activation deficits throughout the cerebrum compared with MSAp and controls. Third, VBM revealed reduced volume in the basal ganglia, middle and inferior cerebellar peduncles, pons, and throughout the cerebrum in MSAp compared with controls and PD, and additionally throughout the cerebellar cortex and vermis in MSAp compared with controls. Collectively, these results provide the first evidence that fMRI activation is abnormal in the basal ganglia, cerebellum, and cerebrum in MSAp, and that a key distinguishing feature between MSAp and PD is the extensive and widespread volume loss throughout the brain in MSAp.

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Association Between Motor Symptoms and Brain Metabolism in Early Huntington Disease

et al. 2017

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IMPORTANCE Brain hypometabolism is associated with the clinical consequences of the degenerative process, but little is known about regional hypermetabolism, sometimes observed in the brain of patients with clinically manifest Huntington disease (HD). Studying the role of regional hypermetabolism is needed to better understand its interaction with the motor symptoms of the disease.OBJECTIVE To investigate the association between brain hypometabolism and hypermetabolism with motor scores of patients with early HD. DESIGN, SETTING, AND PARTICIPANTSThis study started in 2001, and analysis was completed in 2016. Sixty symptomatic patients with HD and 15 healthy age-matched control individuals underwent positron emission tomography to measure cerebral metabolism in this cross-sectional study. They also underwent the Unified Huntington's Disease Rating Scale motor test, and 2 subscores were extracted: (1) a hyperkinetic score, combining dystonia and chorea, and (2) a hypokinetic score, combining bradykinesia and rigidity.MAIN OUTCOMES AND MEASURES Statistical parametric mapping software (SPM5) was used to identify all hypo-and hypermetabolic regions in patients with HD relative to control individuals. Correlation analyses (P < .001, uncorrected) between motor subscores and brain metabolic values were performed for regions with significant hypometabolism and hypermetabolism.RESULTS Among 60 patients with HD, 22 were women (36.7%), and the mean (SD) age was 44.6 (7.6) years. Of the 15 control individuals, 7 were women (46.7%), and the mean (SD) age was 42.2 (7.3) years. In statistical parametric mapping, striatal hypometabolism was significantly correlated with the severity of all motor scores. Hypermetabolism was negatively correlated only with hypokinetic scores in the cuneus (z score = 3.95, P < .001), the lingual gyrus (z score = 4.31, P < .001), and the crus I/II of the cerebellum (z score = 3.77, P < .001), a region connected to associative cortical areas. More severe motor scores were associated with higher metabolic values in the inferior parietal lobule, anterior cingulate, inferior temporal lobule, the dentate nucleus, and the cerebellar lobules IV/V, VI, and VIII bilaterally corresponding to the motor regions of the cerebellum (z score = 3.96 and 3.42 in right and left sides, respectively; P < .001). CONCLUSIONS AND RELEVANCEStriatal hypometabolism is associated with clinical disease severity. Conversely, hypermetabolism is likely compensatory in regions where it is associated with decreasing motor scores. Hypermetabolism might be detrimental in other structures in which it is associated with more severe motor symptoms. In the cerebellum, both compensatory and detrimental contributions seem to occur. This study helps to better understand the motor clinical relevance of hypermetabolic brain regions in HD.

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Motor activation in multiple system atrophy and Parkinson disease

Cited by 25 publications

References 32 publications

Abnormalities of regional brain function in Parkinson’s disease: a meta-analysis of resting state functional magnetic resonance imaging studies

Abnormalities of regional brain function in Parkinson’s disease: a meta-analysis of resting state functional magnetic resonance imaging studies

Distinct functional and macrostructural brain changes in Parkinson's disease and multiple system atrophy

Association Between Motor Symptoms and Brain Metabolism in Early Huntington Disease

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