Motor abnormalities in first-episode psychosis patients and long-term psychosocial functioning

Cuesta, Manuel J.; Jalón, Elena García de; Campos, María; Moreno-Izco, Lucía; Lorente-Omeñaca, Ruth; Sánchez‐Torres, Ana M.; Peralta, Víctor

doi:10.1016/j.schres.2017.08.050

Cited by 38 publications

(26 citation statements)

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“…Those regions have primarily been associated with motor functions, and while there is clear evidence for motor dysfunctions in schizophrenia and other psychotic disorders (Peralta and Cuesta, 2001; Cuesta et al ., 2018; Hirjak et al ., 2018), there is limited evidence in schizotypy (Roché et al ., 2015). As motor functions were not assessed in this study, we can neither assume nor exclude such an association in our data.…”

Section: Discussionmentioning

confidence: 99%

The association of striatal volume and positive schizotypy in healthy subjects: intelligence as a moderating factor

2019

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BackgroundSchizotypy, a putative schizophrenia endophenotype, has been associated with brain-structural variations partly overlapping with those in psychotic disorders. Variations in precuneus structure have been repeatedly reported, whereas the involvement of fronto-striatal networks – as in schizophrenia – is less clear. While shared genetic architecture is thought to increase vulnerability to environmental insults, beneficial factors like general intelligence might buffer their effect.MethodsTo further investigate the role of fronto-striatal networks in schizotypy, we examined the relationship of voxel- and surface-based brain morphometry and a measure of schizotypal traits (Schizotypal Personality Questionnaire, with subscores Cognitive-Perceptual, Interpersonal, Disorganised) in 115 healthy participants [54 female, mean age (s.d.) = 27.57(8.02)]. We tested intelligence (MWT-B) as a potential moderator.ResultsWe found a positive association of SPQ Cognitive-Perceptual with putamen volume (p = 0.040, FWE peak level-corrected), moderated by intelligence: with increasing IQ, the correlation of SPQ Cognitive-Perceptual and striatal volume decreased (p = 0.022). SPQ Disorganised was positively correlated with precentral volume (p = 0.013, FWE peak level-corrected). In an exploratory analysis (p < 0.001, uncorrected), SPQ total score was positively associated with gyrification in the precuneus and postcentral gyrus, and SPQ Disorganised was negatively associated with gyrification in the inferior frontal gyrus.ConclusionsOur findings support the role of fronto-striatal networks for schizotypal features in healthy individuals, and suggest that these are influenced by buffering factors like intelligence. We conclude that protective factors, like general cognitive capacity, might attenuate the psychosis risk associated with schizotypy. These results endorse the idea of a continuous nature of schizotypy, mirroring similar findings in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

The association of striatal volume and positive schizotypy in healthy subjects: intelligence as a moderating factor

2019

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“…Journal of Psychiatry and Brain Science 6 of 33 (specifically, social and occupational functioning using the SOFAS) [37] and overall quality of life (using the WHO-QOL) [38]. Our group and others have shown that motor disturbance predicts social and role functioning outcomes in other clinical populations (e.g., psychosis risk, psychosis) [39,40], but this is the first study examining these associations in depression.…”

Section: The Longitudinal Course Of Motor Behaviormentioning

confidence: 95%

“…A key aspect of NIMH's RDoC initiative is to utilize multiple units of analysis to measure a construct [40,71,72]. The current study adopts this…”

Section: Study Instrumentsmentioning

confidence: 99%

An Examination of Psychomotor Disturbance in Current and Remitted MDD: An RDoC Study

Shankman

Mittal

Walther

2020

J Psychiatry Brain Sci

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Major depressive disorder (MDD) is a serious public health problem that has, at best, modest treatment response-potentially due to its heterogeneous clinical presentation. One way to parse the heterogeneity is to investigate the role of particular features of MDD, an endeavor that can also help identify novel and focal targets for treatment and prevention efforts. Our R01 focuses on the feature of psychomotor disturbance (e.g., psychomotor agitation (PmA) and retardation (PmR)), a particularly pernicious feature of MDD, that has not been examined extensively in MDD. Aim 1 is comparing three groups of individuals-those with current MDD (n = 100), remitted MDD (n = 100), and controls (n = 50)-on multiple measures of PmR and PmA (assessed both in the lab and in the subjects' natural environment). Aim 2 is examining the structural (diffusion MRI) and functional (resting state fMRI) connectivity of motor circuitry of the three groups as well as the relation between motor circuitry and the proposed indicators of PmR and PmA. Aim 3 is following up with subjects three times over 18 months to evaluate whether motor symptoms change in tandem with overall depressive symptoms and functioning over time and/or whether baseline PmR/PmA predicts course of depression and functioning. Aim 3 is particularly clinically significant. Finding that motor functioning and overall depression severity co-vary over time, or that motor variables predict subsequent change in overall depression severity, would support the potential clinical utility of these novel, reliable, and easily administered motor assessments.

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“…Besides movement abnormalities being predictors for the risk of developing schizophrenia, they are also indicative of poor social and cognitive functioning, affecting the overall quality of life of patients (Putzhammer et al, 2005). For example, NSS, parkinsonism, catatonia, dyskinesia, and akathisia reported in patients with the first episode of psychosis were strongly associated with the emergence of negative symptoms, executive dysfunctioning, and poor memory abilities (Cuesta et al, 2014(Cuesta et al, , 2018aWalther et al, 2015;Fritze et al, 2020;Sambataro et al, 2020;Schroder and Toro, 2020). This was true in both medicated and non-medicated patients.…”

Section: The Ramifications Of Movement Abnormalitiesmentioning

confidence: 96%

Using Virtual Reality as a Tool in the Rehabilitation of Movement Abnormalities in Schizophrenia

Pavlidou

Walther

2021

Front. Psychol.

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Movement abnormalities are prevalent across all stages of schizophrenia contributing to poor social functioning and reduced quality of life. To date, treatments are scarce, often involving pharmacological agents, but none have been shown to improve movement abnormalities effectively. Virtual reality (VR) is a tool used to simulate virtual environments where behavioral performance can be quantified safely across different tasks while exerting control over stimulus delivery, feedback and measurement in real time. Sensory information is transmitted via a head mounted display allowing users to directly interact with virtual objects and bodies using gestures and body movements in the real world to perform different actions, permitting a sense of immersion in the simulated virtual environment. Although, VR has been widely used for successful motor rehabilitation in a variety of different neurological domains, none have been exploited for motor rehabilitation in schizophrenia. The objectives of this article are to review movement abnormalities specific to schizophrenia, and how VR can be utilized to restore and improve motor functioning in patients with schizophrenia. Constructing VR-mediated motor-cognitive interventions that can help in retaining and transferring the learned outcomes to real life are also discussed.

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Motor abnormalities in first-episode psychosis patients and long-term psychosocial functioning

Cited by 38 publications

References 50 publications

The association of striatal volume and positive schizotypy in healthy subjects: intelligence as a moderating factor

The association of striatal volume and positive schizotypy in healthy subjects: intelligence as a moderating factor

An Examination of Psychomotor Disturbance in Current and Remitted MDD: An RDoC Study

Using Virtual Reality as a Tool in the Rehabilitation of Movement Abnormalities in Schizophrenia

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