Motivational versus motor impairment after haloperidol injection or 6-OHDA lesions in the ventral tegmental area or substantia nigra in rats

Papp, Mariusz; Bal, Anna

doi:10.1016/0031-9384(86)90042-9

Cited by 17 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clearly, such an action on the nigrostriatal DA system may be relevant for the purported antiparkinsonian effect of the drug. In addition, ritanserin-induced activation of the mesolimbic DA cells may serve as one underlying mechanism for the mood elevating action of the compound as well as associated enhancement of motivation and drive, since the mesolimbic DA system has been profoundly implicated both in reward mechanisms (see Bozarth 1986) and in motivational behaviour (Papp and Bal 1986). …”

Section: Discussionmentioning

confidence: 98%

Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition

1989

View full text Add to dashboard Cite

The effect of systemic administration of ritanserin (R 55667), a 5-hydroxytryptamine (5-HT2) receptor antagonist, on midbrain dopamine (DA) neurons was studied with single cell recording techniques in the chloral hydrate anesthetized male rat. Dopamine cells of the zona compacta, substantia nigra (ZC-SN) and the ventral tegmental area (VTA) were identified by established criteria. Ritanserin (0.5-2.0 mg/kg, IV) dose-dependently increased both the burst firing and firing rate of the midbrain DA neurons. These effects were prevented by endogenous 5-HT depletion through pretreatment with the 5-HT synthesis inhibitor para-chlorophenylalanine (PCPA, 300 mg/kg, IP, x3), which did not significantly alter the firing characteristics of the midbrain DA cells when given alone. These results suggest that 5-HT exerts an inhibitory control of midbrain DA cell activity mediated by 5-HT2 receptors. The stimulatory effect of ritanserin on midbrain DA systems might contribute to some of its clinical effects, such as improvement of mood, drive and motivation as well as its therapeutic actions in parkinsonism and type II schizophrenia.

show abstract

Section: Discussionmentioning

confidence: 98%

Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition

1989

View full text Add to dashboard Cite

show abstract

“…Initial studies that depleted dopamine neurons in the VTA [29] reported no effect on body weight despite increased locomotor activity and deficits in passive-avoidance behavior. To our knowledge, while VTA dopamine neuron depletions can influence a wide range of higher-order behavior, such as drug self-administration [64], motivation [65; 66], perseveration [4; 30], and memory [67], no data suggests that mesolimbic dopamine neuron depletions specifically impact feeding. However, negative data in dopamine neuron depletion experiments are somewhat difficult to interpret, as small amounts of residual dopamine function may be sufficient for critical feeding-related signals.…”

Section: Central Dopaminergic Pathwaysmentioning

confidence: 99%

Metabolic hormones, dopamine circuits, and feeding

Narayanan¹,

Guarnieri²,

DiLeone³

2010

Frontiers in Neuroendocrinology

151

121

View full text Add to dashboard Cite

Recent evidence has emerged demonstrating that metabolic hormones such as ghrelin and leptin can act on ventral tegmental area (VTA) midbrain dopamine neurons to influence feeding. The VTA is the origin of mesolimbic dopamine neurons that project to the nucleus accumbens (NAc) to influence behavior. While blockade of dopamine via systemic antagonists or targeted gene delete can impair food intake, local NAc dopamine manipulations have little effect on food intake. Notably, non-dopaminergic manipulations in the VTA and NAc produce more consistent effects on feeding and food choice. More recent genetic evidence supports a role for the substantia nigra-striatal dopamine pathways in food intake, while the VTA-NAc circuit is more likely involved in higher-order aspects of food acquisition, such as motivation and cue associations. This rich and complex literature should be considered in models of how peripheral hormones influence feeding behavior via action on the midbrain circuits.

show abstract

“…In addition, administration of tetrahydro-ß-carboline, a benzodiazepine ligand, into the hippocampal formation induces a state of "anxiety" in the rat (16). On the other hand, some evidence indicates that the nucleus accumbens, the ventral tegmental area and the hippocampus may be involved in the motivational processes (2,3,8,15,17,18). Regarding the hippocampal structure, local microinjection of histamine into the ventral hippocampus has been shown to reduce the exploratory activity in a holeboard.…”

Section: Introductionmentioning

confidence: 99%

Hippocampal histamine receptors and conflictive exploration in the rat: studies using the elevated asymmetric plus-maze

Ruarte¹,

Orofino²,

Alvarez

1997

Braz J Med Biol Res

View full text Add to dashboard Cite

The possible role of histamine receptors in the hippocampal formation on the exploratory motivation and emotionality of the rat was studied. An elevated asymmetric plus-maze composed of 4 different arms (no walls, single high wall, high and low walls and two high walls) arranged at 90 o angles was used. The exploration score, considered to be an index of exploratory motivation, and the permanency score, considered to be an index of emotionality (anxiety), were determined. Histamine was administered locally into the ventral hippocampus at three different doses (9, 45 and 90 nmol). Another group of rats was also microinjected with 45 nmol of pyrilamine (a histamine H 1 receptor antagonist) or ranitidine (a histamine H 2 receptor antagonist) in addition to 9 nmol of histamine in order to identify the possible type of histamine receptor involved. Histamine administration significantly inhibited the exploration score and increased the permanency score at the doses of 9 and 45 nmol in two of four arms. These effects were completely blocked by the administration of either histamine receptor antagonist. The present results suggest that in the hippocampal formation histamine inhibits exploratory motivation and decreases emotionality by activating both types of histamine receptors. Also, the elevated asymmetric plus-maze appears to be a suitable technique to quantify exploration and possibly "anxiety".

show abstract

Motivational versus motor impairment after haloperidol injection or 6-OHDA lesions in the ventral tegmental area or substantia nigra in rats

Cited by 17 publications

References 29 publications

Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition

Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition

Metabolic hormones, dopamine circuits, and feeding

Hippocampal histamine receptors and conflictive exploration in the rat: studies using the elevated asymmetric plus-maze

Contact Info

Product

Resources

About